Search Results - "Inaba, Kenji"

Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms by Bui, Han Ba, Inaba, Kenji

“…Zinc transporters take up/release zinc ions (Zn ) across biological membranes and maintain intracellular and intra-organellar Zn homeostasis. Since this…”
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Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump by Zhang, Yuxia, Inaba, Kenji

“…Sarco/endoplasmic reticulum Ca2+ ATPase 2b (SERCA2b), a member of the SERCA family, is expressed ubiquitously and transports Ca2+ into the sarco/endoplasmic…”
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Structures and functions of protein disulfide isomerase family members involved in proteostasis in the endoplasmic reticulum by Okumura, Masaki, Kadokura, Hiroshi, Inaba, Kenji

“…The endoplasmic reticulum (ER) is an essential cellular compartment in which an enormous number of secretory and cell surface membrane proteins are synthesized…”
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Visualization of structural dynamics of protein disulfide isomerase enzymes in catalysis of oxidative folding and reductive unfolding by Okumura, Masaki, Noi, Kentaro, Inaba, Kenji

“…Time-resolved single-molecule observations by high-speed atomic force microscopy (HS-AFM), have greatly advanced our understanding of how proteins operate to…”
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Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding by Okumura, Masaki, Noi, Kentaro, Kanemura, Shingo, Kinoshita, Misaki, Saio, Tomohide, Inoue, Yuichi, Hikima, Takaaki, Akiyama, Shuji, Ogura, Teru, Inaba, Kenji

“…Time-resolved direct observations of proteins in action provide essential mechanistic insights into biological processes. Here, we present mechanisms of action…”
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Disulfide bond formation network in the three biological kingdoms, bacteria, fungi and mammals by Sato, Yoshimi, Inaba, Kenji

“…Almost all organisms, from bacteria to humans, possess catalytic systems that promote disulfide bond formation‐coupled protein folding, i.e. oxidative protein…”
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Structure, mechanism, and evolution of Ero1 family enzymes by Araki, Kazutaka, Inaba, Kenji

“…Disulfide bond formation is an essential reaction involved in the folding and maturation of many secreted and membrane proteins. Both prokaryotic and…”
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Zinc regulates ERp44-dependent protein quality control in the early secretory pathway by Watanabe, Satoshi, Amagai, Yuta, Sannino, Sara, Tempio, Tiziana, Anelli, Tiziana, Harayama, Manami, Masui, Shoji, Sorrentino, Ilaria, Yamada, Momo, Sitia, Roberto, Inaba, Kenji

“…Zinc ions (Zn 2+ ) are imported into the early secretory pathway by Golgi-resident transporters, but their handling and functions are not fully understood…”
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The Protein Disulfide Isomerase Family: from proteostasis to pathogenesis by Matsusaki, Motonori, Kanemura, Shingo, Kinoshita, Misaki, Lee, Young-Ho, Inaba, Kenji, Okumura, Masaki

“…In mammalian cells, nearly one-third of proteins are inserted into the endoplasmic reticulum (ER), where they undergo oxidative folding and chaperoning…”
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PDI Family Members as Guides for Client Folding and Assembly by Kanemura, Shingo, Matsusaki, Motonori, Inaba, Kenji, Okumura, Masaki

“…Complicated and sophisticated protein homeostasis (proteostasis) networks in the endoplasmic reticulum (ER), comprising disulfide catalysts, molecular…”
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Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics by Akaike, Takaaki, Ida, Tomoaki, Wei, Fan-Yan, Nishida, Motohiro, Kumagai, Yoshito, Alam, Md. Morshedul, Ihara, Hideshi, Sawa, Tomohiro, Matsunaga, Tetsuro, Kasamatsu, Shingo, Nishimura, Akiyuki, Morita, Masanobu, Tomizawa, Kazuhito, Nishimura, Akira, Watanabe, Satoshi, Inaba, Kenji, Shima, Hiroshi, Tanuma, Nobuhiro, Jung, Minkyung, Fujii, Shigemoto, Watanabe, Yasuo, Ohmuraya, Masaki, Nagy, Péter, Feelisch, Martin, Fukuto, Jon M., Motohashi, Hozumi

“…Cysteine hydropersulfide (CysSSH) occurs in abundant quantities in various organisms, yet little is known about its biosynthesis and physiological functions…”
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Prevention of postoperative peritoneal adhesions: a review of the literature by Schnüriger, Beat, M.D, Barmparas, Galinos, M.D, Branco, Bernardino C., M.D, Lustenberger, Thomas, M.D, Inaba, Kenji, M.D., F.R.C.S.C., F.A.C.S, Demetriades, Demetrios, M.D., Ph.D., F.A.C.S

“…Abstract Background Postoperative adhesions are a significant health problem with major implications on quality of life and health care expenses. The purpose…”
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Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport by Watanabe, Satoshi, Kise, Yoshiaki, Yonezawa, Kento, Inoue, Mariko, Shimizu, Nobutaka, Nureki, Osamu, Inaba, Kenji

“…ERGIC-53 transports certain subsets of newly synthesized secretory proteins and membrane proteins from the endoplasmic reticulum to the Golgi apparatus…”
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Effect of door-to-angioembolization time on mortality in pelvic fracture: Every hour of delay counts by Matsushima, Kazuhide, Piccinini, Alice, Schellenberg, Morgan, Cheng, Vincent, Heindel, Patrick, Strumwasser, Aaron, Benjamin, Elizabeth, Inaba, Kenji, Demetriades, Demetrios

“…Angioembolization (AE) is widely used for hemorrhagic control in patients with pelvic fracture. The latest version of the Resources for Optimal Care of the…”
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Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER–Golgi interface by Watanabe, Satoshi, Harayama, Manami, Kanemura, Shingo, Sitia, Roberto, Inaba, Kenji

“…ERp44 retrieves some endoplasmic reticulum (ER)-resident enzymes and immature oligomers of secretory proteins from the Golgi. Association of ERp44 with its…”
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Surgical trends in the management of acute cholecystitis during pregnancy by Cheng, Vincent, Matsushima, Kazuhide, Sandhu, Kulmeet, Ashbrook, Matthew, Matsuo, Koji, Inaba, Kenji, Demetriades, Demetrios

“…Background Since 2007, clinical practice guidelines by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) recommend early surgical…”
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Methods to identify the substrates of thiol‐disulfide oxidoreductases by Fujimoto, Takushi, Inaba, Kenji, Kadokura, Hiroshi

“…The formation of a disulfide bond is a critical step in the folding of numerous secretory and membrane proteins and catalyzed in vivo. A variety of mechanisms…”
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Characterization of the endoplasmic reticulum–resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding by Kanemura, Shingo, Sofia, Elza Firdiani, Hirai, Naoya, Okumura, Masaki, Kadokura, Hiroshi, Inaba, Kenji

“…Oxidative protein folding occurs primarily in the mammalian endoplasmic reticulum, enabled by a diverse network comprising more than 20 members of the protein…”
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Flail Chest: Less Deadly than Originally Thought by Benjamin, Elizabeth, Recinos, Gustavo, Aiolfi, Alberto, Inaba, Kenji, Demetriades, Demetrios

“…Introduction Flail chest is considered a highly morbid condition with reported mortality ranging from 10 to 20%. It is often associated with other severe…”
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Impact of Fibrinogen Levels on Outcomes after Acute Injury in Patients Requiring a Massive Transfusion by Inaba, Kenji, MD, FACS, Karamanos, Efstathios, MD, Lustenberger, Thomas, MD, Schöchl, Herbert, MD, Shulman, Ira, MD, Nelson, Janice, MD, Rhee, Peter, MD, FACS, Talving, Peep, MD, FACS, Lam, Lydia, MD, FACS, Demetriades, Demetrios, MD, PhD, FACS

“…Background For critically injured patients requiring a massive transfusion, the optimal plasma fibrinogen level is unknown. The purpose of this study was to…”
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