Search Results - "In het Panhuis, Wietse"

Getting in the zone: Metabolite transport across liver zones by Graaf, Stan F. J., Paulusma, Coen C., In het Panhuis, Wietse

“…The liver has many functions including the regulation of nutrient and metabolite levels in the systemic circulation through efficient transport into and out of…”
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Time to run: Late rather than early exercise training in mice remodels the gut microbiome and reduces atherosclerosis development by Schönke, Milena, Ying, Zhixiong, Kovynev, Artemiy, In het Panhuis, Wietse, Binnendijk, Anne, van der Poel, Sabine, Pronk, Amanda C. M., Streefland, Trea C. M., Hoekstra, Menno, Kooijman, Sander, Rensen, Patrick C. N.

“…The metabolic and inflammatory processes that are implicated in the development of cardiovascular diseases are under control of the biological clock. While…”
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A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice by Kuipers, Eline N, Held, Ntsiki M, In Het Panhuis, Wietse, Modder, Melanie, Ruppert, Philip M M, Kersten, Sander, Kooijman, Sander, Guigas, Bruno, Houtkooper, Riekelt H, Rensen, Patrick C N, Boon, Mariëtte R

“…Brown adipose tissue (BAT) catabolizes glucose and fatty acids to produce heat and thereby contributes to energy expenditure. Long-term high-fat diet (HFD)…”
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Circadian disruption impairs glucose homeostasis in male but not in female mice and is dependent on gonadal sex hormones by In het Panhuis, Wietse, Schönke, Milena, Siebeler, Ricky, Banen, Dorien, Pronk, Amanda C. M., Streefland, Trea C. M., Afkir, Salwa, Sips, Hetty C. M., Kroon, Jan, Rensen, Patrick C. N., Kooijman, Sander

“…Circadian disruption (CD) is the consequence of a mismatch between endogenous circadian rhythms and behavior, and frequently occurs in shift workers. CD has…”
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Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1−/−Ldlr−/− mice by Porteiro, Begoña, Roscam Abbing, Reinout L.P., In het Panhuis, Wietse, de Waart, Dirk R., Duijst, Suzanne, Bolt, Isabelle, Vogels, Esther W., Levels, Johannes H.M., Bosmans, Laura A., Vos, Winnie G., Oude Elferink, Ronald P.J., Lutgens, Esther, van de Graaf, Stan F.J.

“…Bile salts can strongly influence energy metabolism through systemic signaling, which can be enhanced by inhibiting the hepatic bile salt transporter Na+…”
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Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue by van Eenige, Robin, In het Panhuis, Wietse, Schönke, Milena, Jouffe, Céline, Devilee, Thomas H., Siebeler, Ricky, Streefland, Trea C.M., Sips, Hetty C.M., Pronk, Amanda C.M., Vorderman, Ruben H.P., Mei, Hailiang, van Klinken, Jan Bert, van Weeghel, Michel, Uhlenhaut, Nina H., Kersten, Sander, Rensen, Patrick C.N., Kooijman, Sander

“…Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking…”
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A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function by Kroon, Jan, Schilperoort, Maaike, In het Panhuis, Wietse, van den Berg, Rosa, van Doeselaar, Lotte, Verzijl, Cristy R.C., van Trigt, Nikki, Mol, Isabel M., Sips, Hetty H.C.M., van den Heuvel, Jose K., Koorneef, Lisa L., van der Sluis, Ronald J., Fenzl, Anna, Kiefer, Florian W., Vettorazzi, Sabine, Tuckermann, Jan P., Biermasz, Nienke R., Meijer, Onno C., Rensen, Patrick C.N., Kooijman, Sander

“…Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of…”
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Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE3-Leiden.CETP mice by Modder, Melanie, het Panhuis, Wietse In, Li, Mohan, Afkir, Salwa, Dorn, Alexandra L, Pronk, Amanda C M, Streefland, Trea C M, Lalai, Reshma A, Pierrou, Stefan, Nilsson, Stefan K, Olivecrona, Gunilla, Kooijman, Sander, Rensen, Patrick C N, Schönke, Milena

“…Abstract Aims Angiopoietin-like 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase to regulate tissue fatty acid (FA) uptake from triglyceride (TG)-rich…”
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Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females by In Het Panhuis, Wietse, Tsaalbi-Shtylik, Anastasia, Schönke, Milena, van Harmelen, Vanessa, Pronk, Amanda C M, Streefland, Trea C M, Sips, Hetty C M, Afkir, Salwa, Willems van Dijk, Ko, Rensen, Patrick C N, de Wind, Niels, Kooijman, Sander

“…DNA damage responses compete for cellular resources with metabolic pathways, but little is known about the metabolic consequences of impaired DNA replication,…”
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Mild Exercise Does Not Prevent Atherosclerosis in APOE3‐Leiden.CETP Mice or Improve Lipoprotein Profile of Men with Obesity by In het Panhuis, Wietse, Kooijman, Sander, Brouwers, Bram, Verhoeven, Aswin, Pronk, Amanda C.M., Streefland, Trea C.M., Giera, Martin, Schrauwen, Patrick, Rensen, Patrick C.N., Schönke, Milena

“…Objective Exercise has been shown to improve cardiometabolic health, yet neither the molecular connection nor the effects of exercise timing have been…”
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Aging attenuates diurnal lipid uptake by brown adipose tissue by In het Panhuis, Wietse, Schönke, Milena, Siebeler, Ricky, Afkir, Salwa, Baelde, Rianne, Pronk, Amanda C.M., Streefland, Trea C.M., Sips, Hetty C.M., Lalai, Reshma A., Rensen, Patrick C.N., Kooijman, Sander

“…Brown adipose tissue (BAT) contributes to cardiometabolic health by taking up glucose and lipids for oxidation, a process that displays a strong diurnal…”
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NK2R control of energy expenditure and feeding to treat metabolic diseases by Sass, Frederike, Ma, Tao, Ekberg, Jeppe H., Kirigiti, Melissa, Ureña, Mario G., Dollet, Lucile, Brown, Jenny M., Basse, Astrid L., Yacawych, Warren T., Burm, Hayley B., Andersen, Mette K., Nielsen, Thomas S., Tomlinson, Abigail J., Dmytiyeva, Oksana, Christensen, Dan P., Bader, Lindsay, Vo, Camilla T., Wang, Yaxu, Rausch, Dylan M., Kristensen, Cecilie K., Gestal-Mato, María, In het Panhuis, Wietse, Sjøberg, Kim A., Kernodle, Stace, Petersen, Jacob E., Pavlovskyi, Artem, Sandhu, Manbir, Moltke, Ida, Jørgensen, Marit E., Albrechtsen, Anders, Grarup, Niels, Babu, M. Madan, Rensen, Patrick C. N., Kooijman, Sander, Seeley, Randy J., Worthmann, Anna, Heeren, Joerg, Pers, Tune H., Hansen, Torben, Gustafsson, Magnus B. F., Tang-Christensen, Mads, Kilpeläinen, Tuomas O., Myers, Martin G., Kievit, Paul, Schwartz, Thue W., Hansen, Jakob B., Gerhart-Hines, Zachary

“…The combination of decreasing food intake and increasing energy expenditure represents a powerful strategy for counteracting cardiometabolic diseases such as…”
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Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidemia and atherosclerosis development in APOE3-Leiden.CETP mice by Modder, Melanie, Het Panhuis, Wietse In, Li, Mohan, Afkir, Salwa, Dorn, Alexandra L, Pronk, Amanda C M, Streefland, Trea C M, Lalai, Reshma A, Pierrou, Stefan, Nilsson, Stefan K, Olivecrona, Gunilla, Kooijman, Sander, Rensen, Patrick C N, Schönke, Milena

“…Angiopoietin-like 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase to regulate tissue fatty acid uptake from triglyceride-rich lipoproteins such as VLDL…”
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Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE∗3-Leiden.CETP miceResearch in context by Wietse In Het Panhuis, Milena Schönke, Melanie Modder, Hannah E. Tom, Reshma A. Lalai, Amanda C.M. Pronk, Trea C.M. Streefland, Linda W.M. van Kerkhof, Martijn E.T. Dollé, Marie A.C. Depuydt, Ilze Bot, Winnie G. Vos, Laura A. Bosmans, Bram W. van Os, Esther Lutgens, Patrick C.N. Rensen, Sander Kooijman

“…Background: Circadian disturbance (CD) is the consequence of a mismatch between endogenous circadian rhythms, behaviour, and/or environmental cycles, and…”
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Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE∗3-Leiden.CETP mice by In Het Panhuis, Wietse, Schönke, Milena, Modder, Melanie, Tom, Hannah E., Lalai, Reshma A., Pronk, Amanda C.M., Streefland, Trea C.M., van Kerkhof, Linda W.M., Dollé, Martijn E.T., Depuydt, Marie A.C., Bot, Ilze, Vos, Winnie G., Bosmans, Laura A., van Os, Bram W., Lutgens, Esther, Rensen, Patrick C.N., Kooijman, Sander

“…Circadian disturbance (CD) is the consequence of a mismatch between endogenous circadian rhythms, behaviour, and/or environmental cycles, and frequently occurs…”
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