Control of T cell effector functions by miRNAs

Control of T cell effector functions by miRNAs

The differentiation of effector T cells is a tightly regulated process that relies on the selective expression of lineage-defining master regulators that orchestrate unique transcriptional programs, including the production of distinct sets of effector cytokines. miRNAs are post-transcriptional regu...

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Bibliographic Details
Published in:Cancer letters Vol. 427; pp. 63 - 73
Main Authors: Inácio, Daniel P., Amado, Tiago, Silva-Santos, Bruno, Gomes, Anita Q.
Format: Journal Article
Language:English
Published: Ireland Elsevier B.V 28-07-2018
Elsevier Limited
Subjects:
Antigens
Autoimmune diseases
Autoimmunity
Biomarkers
CD4 antigen
CD8 antigen
Cytokines
Cytotoxicity
Disease
Effector cells
Effector T cells
Gene expression
Genotype & phenotype
Helper cells
Inflammation
Lymphocytes
Lymphocytes T
miRNAs
Natural killer cells
Post-transcription
RNA polymerase
T cell differentiation
T cell receptors
T cell regulation
Transcription factors
Tumors
Effector T cells
miRNAs
T cell regulation
T cell differentiation
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Summary:The differentiation of effector T cells is a tightly regulated process that relies on the selective expression of lineage-defining master regulators that orchestrate unique transcriptional programs, including the production of distinct sets of effector cytokines. miRNAs are post-transcriptional regulators that are now viewed as critical players in these gene expression networks and help defining cell identity and function. This review summarises the role of individual miRNAs in the regulation of the differentiation of effector T cell subsets, including CD4+ T helper cells, cytotoxic CD8+ T cells and innate-like NKT cells. Moreover, we refer to miRNAs that have been identified to affect simultaneously two or more effector T cell populations, impacting on the balance between effector T cells in vivo, thus constituting potential biomarkers or targets for therapies aiming at boosting immunity or controlling autoimmunity. •miRNAs as key post-transcriptional regulators of effector T cell differentiation.•miRNAs that act as regulators of CD4 T cell- (Th1, Th2, Th7, Tfh and Treg cells), CD8+ T cell- and NKT cell- differentiation.•Physiological relevance of miRNAs that affect simultaneously two or more effector T cell populations.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2018.04.011