Search Results - "Impronta, Flavia"

Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives by Cefalo, Chiara Maria Assunta, Cinti, Francesca, Moffa, Simona, Impronta, Flavia, Sorice, Gian Pio, Mezza, Teresa, Pontecorvi, Alfredo, Giaccari, Andrea

“…Sotagliflozin is a dual sodium-glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (T1D) and type 2 diabetes (T2D)…”
Get full text

The Interplay between Immune System and Microbiota in Diabetes by Giaccari, Andrea, Pontecorvi, Alfredo, Santoro, Antonio, Sorice, Gian Pio, Impronta, Flavia, Cinti, Francesca, Cefalo, Chiara M. A., Mezza, Teresa, Moffa, Simona, Di Giuseppe, Gianfranco

“…Diabetes is not a single and homogeneous disease, but a cluster of metabolic diseases characterized by the common feature of hyperglycemia. The pathogenesis of…”
Get full text

Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date by Cinti, Francesca, Moffa, Simona, Impronta, Flavia, Cefalo, Chiara Ma, Sun, Vinsin A, Sorice, Gian Pio, Mezza, Teresa, Giaccari, Andrea

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the latest therapeutic strategy in the treatment of type 2 diabetes mellitus (T2DM). Using an…”
Get full text

Effects of PCSK9 inhibition on glucose metabolism and β-cell function in humans: a pilot study by Moffa, Simona, Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Cefalo, Chiara M A, Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Ciccarelli, Gea, Mari, Andrea, Pontecorvi, Alfredo, Giaccari, Andrea

“…Anti-PCSK9 monoclonal antibodies are effective in reducing LDL-C and cardiovascular events by neutralizing circulating PCSK9. PCSK9, however, is also expressed…”
Get full text

Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis by Mezza, Teresa, Moffa, Simona, Ferraro, Pietro Manuel, Quero, Giuseppe, Capece, Umberto, Carfì, Andrea, Cefalo, Chiara M A, Cinti, Francesca, Sorice, Gian Pio, Impronta, Flavia, Mari, Andrea, Pontecorvi, Alfredo, Alfieri, Sergio, Holst, Jens J, Giaccari, Andrea

“…Abstract Objective Changes in bile flow after bariatric surgery may beneficially modulate secretion of insulin and incretins, leading to diabetes remission…”
Get full text

Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes by Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Moffa, Simona, Cefalo, Chiara M.A., Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Quero, Giuseppe, Pontecorvi, Alfredo, Mari, Andrea, Alfieri, Sergio, Giaccari, Andrea

“…BACKGROUND. The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin, and a reduction of ß cell mass…”
Get full text

1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction by DI GIUSEPPE, GIANFRANCO, MARIA ASSUNTA CEFALO, CHIARA, MOFFA, SIMONA, CICCARELLI, GEA, SOLDOVIERI, LAURA, CINTI, FRANCESCA, CAPECE, UMBERTO, IMPRONTA, FLAVIA, MARI, ANDREA, HOLST, JENS J., GIACCARI, ANDREA, MEZZA, TERESA

“…In type 2 diabetes incretin effect (IE) is reduced but still contributes to 20-35% of insulin response to oral glucose. One reason is the impairment of GIP and…”
Get full text

134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans by MOFFA, SIMONA, MEZZA, TERESA, ASSUNTA CEFALO, CHIARA MARIA, CINTI, FRANCESCA, SORICE, GIAN PIO, IMPRONTA, FLAVIA, CAPECE, UMBERTO, MARI, ANDREA, GIACCARI, ANDREA

“…PCSK9 inhibitors are monoclonal antibodies effective in reducing LDL-C and cardiovascular events by neutralizing circulating PCSK9. Since PCSK9 is also…”
Get full text

Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional [beta] cells in predicting diabetes by Mezza, Teresa, Ferraro, Pietro Manuel, Giuseppe, Gianfranco Di, Moffa, Simona, Cefalo, Chiara M.A, Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Quero, Giuseppe, Pontecorvi, Alfredo, Mari, Andrea, Alfieri, Sergio, Giaccari, Andrea

“…BACKGROUND. The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin, and a reduction of [beta] cell mass…”
Get full text

2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction by MEZZA, TERESA, FERRARO, PIETRO MANUEL, GIUSEPPE, GIANFRANCO DI, ASSUNTA CEFALO, CHIARA MARIA, MOFFA, SIMONA, QUERO, GIUSEPPE, CINTI, FRANCESCA, IMPRONTA, FLAVIA, CAPECE, UMBERTO, ALFIERI, SERGIO, MARI, ANDREA, GIACCARI, ANDREA

“…β-cell functional defects temporally anticipate (and eventually cause) the subsequent development of hyperglycemia, whereas a significant reduction (∼50%) of…”
Get full text

290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors by BRUSCO, NOEMI, SEBASTIANI, GUIDO, LICATA, GIADA, GRIECO, GIUSEPPINA E., GIUSEPPE, GIANFRANCO DI, NIGI, LAURA, FIGNANI, DANIELA, MOFFA, SIMONA, CINTI, FRANCESCA, CEFALO, CHIARA MARIA ASSUNTA, CAPECE, UMBERTO, IMPRONTA, FLAVIA, MARI, ANDREA, DOTTA, FRANCESCO, GIACCARI, ANDREA, MEZZA, TERESA

“…Proinsulin (PI) processing is altered in beta-cells during T2D progression. However, the molecular mechanisms driving such alterations are not fully…”
Get full text

Duodenopancreatectomy as a model to demonstrate the fundamental role of dysfunctional β cell in predicting diabetes by Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Moffa, Simona, Cefalo, Chiara Ma, Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Quero, Giuseppe, Pontecorvi, Alfredo, Mari, Andrea, Alfieri, Sergio, Giaccari, Andrea

“…The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin and a reduction of β-cell mass. There is a…”
Get full text