Search Results - "Imoto, I"

SIX1 promotes epithelial–mesenchymal transition in colorectal cancer through ZEB1 activation by Ono, H, Imoto, I, Kozaki, K, Tsuda, H, Matsui, T, Kurasawa, Y, Muramatsu, T, Sugihara, K, Inazawa, J

“…Epithelial–mesenchymal transition (EMT) has a major role in cancer progression, as well as normal organ development and human pathology such as organ fibrosis…”
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Overexpression of SMYD2 contributes to malignant outcome in gastric cancer by Komatsu, S, Ichikawa, D, Hirajima, S, Nagata, H, Nishimura, Y, Kawaguchi, T, Miyamae, M, Okajima, W, Ohashi, T, Konishi, H, Shiozaki, A, Fujiwara, H, Okamoto, K, Tsuda, H, Imoto, I, Inazawa, J, Otsuji, E

“…Background: SET and MYND domain-containing protein 2 (SMYD2) is a lysine methyltransferase for histone H3, p53 and Rb and inhibits their transactivation…”
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Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer by Hosoda, F, Arai, Y, Okada, N, Shimizu, H, Miyamoto, M, Kitagawa, N, Katai, H, Taniguchi, H, Yanagihara, K, Imoto, I, Inazawa, J, Ohki, M, Shibata, T

“…Chromosomal abnormalities are good guideposts when hunting for cancer-related genes. We analyzed copy number alterations of 163 primary gastric cancers using…”
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Novel PAX9 Mutations Cause Non-syndromic Tooth Agenesis by Mitsui, S.N., Yasue, A., Masuda, K., Watanabe, K., Horiuchi, S., Imoto, I., Tanaka, E.

“…PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage…”
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B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P by Inoue, A, Okamoto, K, Fujino, Y, Nakagawa, T, Muguruma, N, Sannomiya, K, Mitsui, Y, Takaoka, T, Kitamura, S, Miyamoto, H, Okahisa, T, Fujimori, T, Imoto, I, Takayama, T

“…Background: Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the…”
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A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity by YU, W, IMOTO, I, INOUE, J, ONDA, M, EMI, M, INAZAWA, J

“…Anaplastic thyroid cancer (ATC) is one of the most lethal of all human tumors, but cytogenetic information concerning ATC is extremely limited. Using our…”
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Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy by Tanaka, S., Arii, S., Yasen, M., Mogushi, K., Su, N. T., Zhao, C., Imoto, I., Eishi, Y., Inazawa, J., Miki, Y., Tanaka, H.

“…Background: Patterns of cancer recurrence hold the key to prognosis after curative resection. This retrospective study aimed to identify a predictor and…”
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Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma by TANAKA, K, IMOTO, I, INAZAWA, J, INOUE, J, KOZAKI, K, TSUDA, H, SHIMADA, Y, AIKO, S, YOSHIZUMI, Y, IWAI, T, KAWANO, T

“…Epigenetic alterations and the resulting inactivation of tumor suppressor genes often contribute to the development of various cancers. To identify novel…”
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DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung by Shibata, T, Kokubu, A, Miyamoto, M, Hosoda, F, Gotoh, M, Tsuta, K, Asamura, H, Matsuno, Y, Kondo, T, Imoto, I, Inazawa, J, Hirohashi, S

“…Lung cancer shows diverse histological subtypes. Large-cell neuroendocrine cell carcinoma and small-cell lung carcinoma show similar histological features and…”
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EP13.08: Prenatal diagnosis of Holt‐Oram syndrome by Maeda, K., Morine, M., Kaji, T., Nakaoku, D., Yamasaki, M., Kondo, A., Hinokio, K., Imoto, I.

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POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17 by Zhao, C, Inoue, J, Imoto, I, Otsuki, T, Iida, S, Ueda, R, Inazawa, J

“…Multiple myeloma (MM), a progressive hematological neoplasm, is thought to result from multiple genetic events affecting the terminal plasma cell. However,…”
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RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2 M arrest by SAIGUSA, K, IMOTO, I, TANIKAWA, C, AOYAGI, M, OHNO, K, NAKAMURA, Y, INAZAWA, J

“…To identify target genes for the hemizygous deletions of chromosome 13 that are recurrently observed in malignant gliomas, we performed genome-wide DNA…”
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Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas by SUGINO, Y, MISAWA, A, INOUEL, J, KITAGAWA, M, HOSOI, H, SUGIMOTO, T, IMOTO, I, INAZAWA, J

“…We previously identified a cluster of prostanoid receptor genes, prostaglandin D2 receptor (PTGDR) and prostaglandin E receptor 2 (PTGER2), as possible targets…”
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Stabilization of phenotypic plasticity through mesenchymal-specific DNA hypermethylation in cancer cells by Kurasawa, Y, Kozaki, K, Pimkhaokham, A, Muramatsu, T, Ono, H, Ishihara, T, Uzawa, N, Imoto, I, Amagasa, T, Inazawa, J

“…The epithelial–mesenchymal transition (EMT) has a crucial role in normal and disease processes including tumor progression. In this study, we first classified…”
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PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation by SUZUKI, E, IMOTO, I, PIMKHAOKHAM, A, NAKAGAWA, T, KAMATA, N, KOZAKI, K.-I, AMAGASA, T, INAZAWA, J

“…Array-based comparative genomic hybridization (array-CGH) has good potential for the high-throughput identification of genetic aberrations in cell genomes. In…”
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Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas by IMOTO, Issei, YANG, Zeng-Quan, PIMKHAOKHAM, Atiphan, TSUDA, Hitoshi, SHIMADA, Yutaka, IMAMURA, Masayuki, OHKI, Misao, INAZAWA, Johji

“…Amplification of chromosomal DNA is thought to be one of the mechanisms that activate cancer-related genes in tumors. In a recent study, we identified high…”
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Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines by YANG, Zeng-Quan, IMOTO, Issei, FUKUDA, Yoji, PIMKHAOKHAM, Atiphan, SHIMADA, Yutaka, IMAMURA, Masayuki, SUGANO, Sumio, NAKAMURA, Yusuke, INAZAWA, Johji

“…In a recent study, we identified frequent amplification of DNA copy number at chromosome 9p23-24 in cell lines derived from esophageal squamous cell carcinomas…”
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Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis by TAKADA, H, IMOTO, I, TSUDA, H, NAKANISHI, Y, SAKAKURA, C, MITSUFUJI, S, HIROHASHI, S, INAZAWA, J

“…Homozygous loss in the genomic sequence, a mechanism for inactivating tumor-suppressor genes (TSGs) in cancer, has been used as a tag for the identification of…”
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Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue by Qi, S, Mogi, S, Tsuda, H, Tanaka, Y, Kozaki, K, Imoto, I, Inazawa, J, Hasegawa, S, Omura, K

“…Abstract Cellular inhibitor-of-apoptosis protein 1 (cIAP-1) is a member of the inhibitor-of- apoptosis protein family, which predominantly regulates apoptosis…”
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Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation by KAWANISHI, H, TAKAHASHI, T, INAZAWA, J, NISHIYAMA, H, OGAWA, O, ITO, M, MATSUI, Y, WATANABE, J, ITO, N, KAMOTO, T, KADOWAKI, T, TSUJIMOTO, G, IMOTO, I

“…The purpose of this study was to investigate the accumulation of genetic alterations during metachronous and/or synchronous development of multifocal low-grade…”
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