Search Results - "Imoto, Hiroshi"

Visualizing cellular interactions with a generalized proximity reporter by Sellmyer, Mark A., Bronsart, Laura, Imoto, Hiroshi, Contag, Christopher H., Wandless, Thomas J., Prescher, Jennifer A.

“…Interactions among neighboring cells underpin many physiological processes ranging from early development to immune responses. When these interactions do not…”
Get full text

Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design by Fujimori, Ikuo, Wakabayashi, Takeshi, Murakami, Morio, Okabe, Atsutoshi, Ishii, Tsuyoshi, McGrath, Aaron, Zou, Hua, Saikatendu, Kumar Singh, Imoto, Hiroshi

“…Fragment screening is frequently used for hit identification. However, there was no report starting from a small fragment for the development of an anaplastic…”
Get full text

反射電子像を用いたベイナイト鋼中のマルテンサイトの選択可視化と機械学習を活用した相分率評価 by 井本, 浩史, 佐藤, 馨, 小形, 健二

“…Multi-phase steels are often used to realize a combination of high strength and toughness and/or ductility. To optimize their mechanical properties, it is…”
Get full text

Length of stay and cost for surgical site infection after abdominal and cardiac surgery in Japanese hospitals: multi-center surveillance by Kusachi, Shinya, Kashimura, Nobuichi, Konishi, Toshiro, Shimizu, Junzo, Kusunoki, Masato, Oka, Masaaki, Wakatsuki, Toshiro, Kobayashi, Junjiro, Sawa, Yoshiki, Imoto, Hiroshi, Motomura, Noboru, Makuuchi, Haruo, Tanemoto, Kazuo, Sumiyama, Yoshinobu

“…This study evaluated the influence of surgical site infections (SSIs) after abdominal or cardiac surgery on the post-operative duration of hospitalization and…”
Get more information

Advanced carbon anode materials for lithium ion cells by Azuma, Hideto, Imoto, Hiroshi, Yamada, Shin'ichiro, Sekai, Koji

“…Three kinds of carbon have been used for commercial cells: graphite, soft carbon and hard carbon. The difference in the structures of these three kinds of…”
Get full text

Orally Active CCR5 Antagonists as Anti-HIV-1 Agents 2: Synthesis and Biological Activities of Anilide Derivatives Containing a Pyridine N-Oxide Moiety by Seto, Masaki, Aramaki, Yoshio, Imoto, Hiroshi, Aikawa, Katsuji, Oda, Tsuneo, Kanzaki, Naoyuki, Iizawa, Yuji, Baba, Masanori, Shiraishi, Mitsuru

“…In order to develop orally active CCR5 antagonists, we investigated 1-benzoxepine derivatives containing new polar substituents, such as phosphonate, phosphine…”
Get full text

Studies on Non-Thiazolidinedione Antidiabetic Agents. 2. Novel Oxyiminoalkanoic Acid Derivatives as Potent Glucose and Lipid Lowering Agents by Imoto, Hiroshi, Sugiyama, Yasuo, Kimura, Hiroyuki, Momose, Yu

“…We previously reported that (Z)-2-{4-[(5-methyl-2-phenyl-1, 3-oxazol-4-yl)methoxy]benzyloxyimino}-2-(4-phenoxyphenyl)acetic acid (3) showed potent glucose and…”
Get full text

Selective Visualization of Martensite in Bainitic Steel Using Backscattered Electron Images and Phase Fraction Evaluation Using Machine Learning by Imoto, Hiroshi, Sato, Kaoru, Ogata, Kenji

“…Multi-phase steels are often used to realize a combination of high strength and toughness and/or ductility. To optimize their mechanical properties, it is…”
Get full text

Exo-Selective Diels-Alder Reaction Based on a Molecular Recognition Approach by Maruoka, Keiji, Imoto, Hiroshi, Yamamoto, Hisashi

Get full text

Studies on Non-Thiazolidinedione Antidiabetic Agents. 1. Discovery of Novel Oxyiminoacetic Acid Derivatives by Imoto, Hiroshi, Imamiya, Eikoh, Momose, Yu, Sugiyama, Yasuo, Kimura, Hiroyuki, Sohda, Takashi

“…A novel series of oxyiminoacetic acid derivatives were synthesized in an effort to develop a potent antidiabetic agent, which does not contain the…”
Get full text

Destabilizing Domains Derived from the Human Estrogen Receptor by Miyazaki, Yusuke, Imoto, Hiroshi, Chen, Ling-chun, Wandless, Thomas J

“…Methods to rapidly and reversibly perturb the functions of specific proteins are desirable tools for studies of complex biological processes. We have…”
Get full text

Kinetic analysis of D-Alanine upon oral intake in humans by Kimura, Tomonori, Sakai, Shinsuke, Horio, Masaru, Takahara, Shiro, Ishigo, Shoto, Nakane, Maiko, Negishi, Eiichi, Imoto, Hiroshi, Mita, Masashi, Hamase, Kenji, Higa-Maekawa, Yoko, Kakuta, Yoichi, Mizui, Masayuki, Isaka, Yoshitaka

“…D-Alanine, a rare enantiomer of alanine, can potentially alleviate the worsening of viral infections and maintain circadian rhythm. This study aimed to analyze…”
Get full text

Studies on Non-Thiazolidinedione Antidiabetic Agents. 3. Preparation and Biological Activity of the Metabolites of TAK-559 by Imoto, Hiroshi, Matsumoto, Mitsuharu, Odaka, Hiroyuki, Sakamoto, Junichi, Kimura, Hiroyuki, Nonaka, Masami, Kiyota, Yutaka, Momose, Yu

“…Preparation and biological activity of the metabolites of the potent antihyperglycemic and antihyperlipidemic agent,…”
Get full text

Discovery of Potent, Selective, and Brain-Penetrant 1H‑Pyrazol-5-yl‑1H‑pyrrolo[2,3‑b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors by Fushimi, Makoto, Fujimori, Ikuo, Wakabayashi, Takeshi, Hasui, Tomoaki, Kawakita, Youichi, Imamura, Keisuke, Kato, Tomoko, Murakami, Morio, Ishii, Tsuyoshi, Kikko, Yorifumi, Kasahara, Maki, Nakatani, Atsushi, Hiura, Yuto, Miyamoto, Maki, Saikatendu, Kumar, Zou, Hua, Lane, Scott Weston, Lawson, J. David, Imoto, Hiroshi

“…Anaplastic lymphoma kinase (ALK), a member of the receptor tyrosine kinase family, is predominantly expressed in the brain and implicated in neuronal…”
Get full text

Clay mineralogy of a podzol developed under a Sciadopitys verticillata forest on Mt. Irazu, Shikoku mountains, southwest Japan by Kitagawa, Y. (Fukui Prefectural Univ., Matsuoka (Japan)), Imoto, H, Kurihara, H

“…A podzolic soil developed under a Sciadopitys verticillata forest on the side of Mt. Irazu in Shikoku mountains, Southwest Japan was investigated mainly by a…”
Get full text

Mineral composition of clay fractions and oxygen vacancies in silt-sized quartz in soils on the Ka-Etsu Plateau, Fukui, Central Japan: Possibility of eolian dust brought from northern Asia as parent material of soils by Kitagawa, Y.(Fukui Prefectural Univ., Matsuoka (Japan)), Imoto, H, Saito, M, Kurihara, H, Fujie, K, Toyoda, S, Naruse, T

“…Fine- to medium-textured soils are distributed on the Early Pliocene rocks and Pleistocene sandy sediments in the Ka-Etsu Plateau. The Jingaoka (JIN) soil was…”
Get full text

Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists by Sato, Kenjiro, Sugimoto, Hiromichi, Rikimaru, Kentaro, Imoto, Hiroshi, Kamaura, Masahiro, Negoro, Nobuyuki, Tsujihata, Yoshiyuki, Miyashita, Hirohisa, Odani, Tomoyuki, Murata, Toshiki

“…A series of indoline carbamate and indolinylpyrimidine derivatives was designed, synthesized, and evaluated as novel GPR119 agonists for the treatment of type…”
Get full text

Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors by Fushimi, Makoto, Fujimori, Ikuo, Wakabayashi, Takeshi, Hasui, Tomoaki, Kawakita, Youichi, Imamura, Keisuke, Kato, Tomoko, Murakami, Morio, Ishii, Tsuyoshi, Kikko, Yorifumi, Kasahara, Maki, Nakatani, Atsushi, Hiura, Yuto, Miyamoto, Maki, Saikatendu, Kumar, Zou, Hua, Lane, Scott Weston, Lawson, J David, Imoto, Hiroshi

“…Anaplastic lymphoma kinase (ALK), a member of the receptor tyrosine kinase family, is predominantly expressed in the brain and implicated in neuronal…”
Get full text

A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides by Rikimaru, Kentaro, Wakabayashi, Takeshi, Abe, Hidenori, Imoto, Hiroshi, Maekawa, Tsuyoshi, Ujikawa, Osamu, Murase, Katsuhito, Matsuo, Takanori, Matsumoto, Mitsuharu, Nomura, Chisako, Tsuge, Hiroko, Arimura, Naoto, Kawakami, Kazutoshi, Sakamoto, Junichi, Funami, Miyuki, Mol, Clifford D., Snell, Gyorgy P., Bragstad, Kenneth A., Sang, Bi-Ching, Dougan, Douglas R., Tanaka, Toshimasa, Katayama, Nozomi, Horiguchi, Yoshiaki, Momose, Yu

“…Herein, we describe the design, synthesis, and structure–activity relationships of novel benzylpyrazole acylsulfonamides as non-thiazolidinedione (TZD),…”
Get full text

Structure–activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists by Rikimaru, Kentaro, Wakabayashi, Takeshi, Abe, Hidenori, Tawaraishi, Taisuke, Imoto, Hiroshi, Yonemori, Jinichi, Hirose, Hideki, Murase, Katsuhito, Matsuo, Takanori, Matsumoto, Mitsuharu, Nomura, Chisako, Tsuge, Hiroko, Arimura, Naoto, Kawakami, Kazutoshi, Sakamoto, Junichi, Funami, Miyuki, Mol, Clifford D., Snell, Gyorgy P., Bragstad, Kenneth A., Sang, Bi-Ching, Dougan, Douglas R., Tanaka, Toshimasa, Katayama, Nozomi, Horiguchi, Yoshiaki, Momose, Yu

“…In our search for a novel class of non-TZD, non-carboxylic acid peroxisome proliferator-activated receptor (PPAR) γ agonists, we explored alternative…”
Get full text