Search Results - "Immunological reviews"

Overview of the IL‐1 family in innate inflammation and acquired immunity by Dinarello, Charles A.

“…Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology because the IL‐1 family and Toll‐like receptor (TLR) families share…”
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Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease by Pickard, Joseph M., Zeng, Melody Y., Caruso, Roberta, Núñez, Gabriel

“…Summary The intestinal tract of mammals is colonized by a large number of microorganisms including trillions of bacteria that are referred to collectively as…”
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Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases by Man, Si Ming, Karki, Rajendra, Kanneganti, Thirumala‐Devi

“…Summary Cell death is a fundamental biological phenomenon that is essential for the survival and development of an organism. Emerging evidence also indicates…”
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Interleukin‐33 (IL‐33): A nuclear cytokine from the IL‐1 family by Cayrol, Corinne, Girard, Jean‐Philippe

“…Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family abundantly expressed in endothelial cells, epithelial cells and…”
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The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis) by Zheng, Min, Kanneganti, Thirumala‐Devi

“…ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA products but also endogenous nucleic acid ligands. ZBP1 sensing of the…”
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Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines by Sette, Alessandro, Crotty, Shane

“…Immunological memory is the basis of protective immunity provided by vaccines and previous infections. Immunological memory can develop from multiple branches…”
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Mast cells as sources of cytokines, chemokines, and growth factors by Mukai, Kaori, Tsai, Mindy, Saito, Hirohisa, Galli, Stephen J.

“…Summary Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that represent potential sources of a wide variety of…”
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Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease by Goldblatt, David, Alter, Galit, Crotty, Shane, Plotkin, Stanley A.

“…Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐CoV‐2 coronavirus. Measurement of those antibodies by neutralization…”
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LAG3 (CD223) as a cancer immunotherapy target by Andrews, Lawrence P., Marciscano, Ariel E., Drake, Charles G., Vignali, Dario A. A.

“…Summary Despite the impressive impact of CTLA4 and PD1‐PDL1‐targeted cancer immunotherapy, a large proportion of patients with many tumor types fail to…”
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The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets by Allard, Bertrand, Longhi, Maria Serena, Robson, Simon C., Stagg, John

“…Summary Cancers are able to grow by subverting immune suppressive pathways, to prevent the malignant cells as being recognized as dangerous or foreign. This…”
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Tim‐3 and its role in regulating anti‐tumor immunity by Das, Madhumita, Zhu, Chen, Kuchroo, Vijay K.

“…Summary Immunotherapy is being increasingly recognized as a key therapeutic modality to treat cancer and represents one of the most exciting treatments for the…”
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Caspase‐8: regulating life and death by Tummers, Bart, Green, Douglas R.

“…Summary Roles for cell death in development, homeostasis, and the control of infections and cancer have long been recognized. Although excessive cell damage…”
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The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens by Kim, Sohn, Covington, April, Pamer, Eric G.

“…Summary The human gastrointestinal tract hosts a diverse network of microorganisms, collectively known as the microbiota that plays an important role in health…”
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Interleukin‐18: Biological properties and role in disease pathogenesis by Kaplanski, Gilles

“…Summary Initially described as an interferon (IFN)γ‐inducing factor, interleukin (IL)‐18 is indeed involved in Th1 and NK cell activation, but also in Th2,…”
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The immune system's role in sepsis progression, resolution, and long-term outcome by Delano, Matthew J., Ward, Peter A.

“…Summary Sepsis occurs when an infection exceeds local tissue containment and induces a series of dysregulated physiologic responses that result in organ…”
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T‐cell exhaustion in HIV infection by Fenwick, Craig, Joo, Victor, Jacquier, Patricia, Noto, Alessandra, Banga, Riddhima, Perreau, Matthieu, Pantaleo, Giuseppe

“…The T‐cell response is central in the adaptive immune‐mediated elimination of pathogen‐infected and/or cancer cells. This activated T‐cell response can inflict…”
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The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity by Ovsyannikova, Inna G., Haralambieva, Iana H., Crooke, Stephen N., Poland, Gregory A., Kennedy, Richard B.

“…This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to…”
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Immunometabolism: From basic mechanisms to translation by Makowski, Liza, Chaib, Mehdi, Rathmell, Jeffrey C.

“…Immunometabolism has emerged as a major mechanism central to adaptive and innate immune regulation. From early observations that inflammatory cytokines were…”
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STING pathway agonism as a cancer therapeutic by Flood, Blake A., Higgs, Emily F., Li, Shuyin, Luke, Jason J., Gajewski, Thomas F.

“…The fact that a subset of human cancers showed evidence for a spontaneous adaptive immune response as reflected by the T cell‐inflamed tumor microenvironment…”
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Regulation of inflammasome activation by Man, Si Ming, Kanneganti, Thirumala-Devi

“…Summary Inflammasome biology is one of the most exciting and rapidly growing areas in immunology. Over the past 10 years, inflammasomes have been recognized…”
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