Search Results - "Immunity (Cambridge, Mass.)"

Inflammation in obesity, diabetes, and related disorders by Rohm, Theresa V., Meier, Daniel T., Olefsky, Jerrold M., Donath, Marc Y.

“…Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell dysfunction, and ultimately type 2 diabetes (T2D). This chronic…”
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Immunology of COVID-19: Current State of the Science by Vabret, Nicolas, Britton, Graham J., Gruber, Conor, Hegde, Samarth, Kim, Joel, Kuksin, Maria, Levantovsky, Rachel, Malle, Louise, Moreira, Alvaro, Park, Matthew D., Pia, Luisanna, Risson, Emma, Saffern, Miriam, Salomé, Bérengère, Esai Selvan, Myvizhi, Spindler, Matthew P., Tan, Jessica, van der Heide, Verena, Gregory, Jill K., Alexandropoulos, Konstantina, Bhardwaj, Nina, Brown, Brian D., Greenbaum, Benjamin, Gümüş, Zeynep H., Homann, Dirk, Horowitz, Amir, Kamphorst, Alice O., Curotto de Lafaille, Maria A., Mehandru, Saurabh, Merad, Miriam, Samstein, Robert M., Agrawal, Manasi, Aleynick, Mark, Belabed, Meriem, Brown, Matthew, Casanova-Acebes, Maria, Catalan, Jovani, Centa, Monica, Charap, Andrew, Chan, Andrew, Chen, Steven T., Chung, Jonathan, Bozkus, Cansu Cimen, Cody, Evan, Cossarini, Francesca, Dalla, Erica, Fernandez, Nicolas, Grout, John, Ruan, Dan Fu, Hamon, Pauline, Humblin, Etienne, Jha, Divya, Kodysh, Julia, Leader, Andrew, Lin, Matthew, Lindblad, Katherine, Lozano-Ojalvo, Daniel, Lubitz, Gabrielle, Magen, Assaf, Mahmood, Zafar, Martinez-Delgado, Gustavo, Mateus-Tique, Jaime, Meritt, Elliot, Moon, Chang, Noel, Justine, O’Donnell, Tim, Ota, Miyo, Plitt, Tamar, Pothula, Venu, Redes, Jamie, Reyes Torres, Ivan, Roberto, Mark, Sanchez-Paulete, Alfonso R., Shang, Joan, Schanoski, Alessandra Soares, Suprun, Maria, Tran, Michelle, Vaninov, Natalie, Wilk, C. Matthias, Aguirre-Ghiso, Julio, Bogunovic, Dusan, Cho, Judy, Faith, Jeremiah, Grasset, Emilie, Heeger, Peter, Kenigsberg, Ephraim, Krammer, Florian, Laserson, Uri

“…The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people…”
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Inflammation and Cancer: Triggers, Mechanisms, and Consequences by Greten, Florian R., Grivennikov, Sergei I.

“…Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory…”
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Top 10 Challenges in Cancer Immunotherapy by Hegde, Priti S., Chen, Daniel S.

“…Cancer immunotherapy is a validated and critically important approach for treating patients with cancer. Given the vast research and clinical investigation…”
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Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals by Ni, Ling, Ye, Fang, Cheng, Meng-Li, Feng, Yu, Deng, Yong-Qiang, Zhao, Hui, Wei, Peng, Ge, Jiwan, Gou, Mengting, Li, Xiaoli, Sun, Lin, Cao, Tianshu, Wang, Pengzhi, Zhou, Chao, Zhang, Rongrong, Liang, Peng, Guo, Han, Wang, Xinquan, Qin, Cheng-Feng, Chen, Fang, Dong, Chen

“…The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune…”
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Herd Immunity: Understanding COVID-19 by Randolph, Haley E., Barreiro, Luis B.

“…The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease, COVID-19, has demonstrated the devastating impact of…”
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SARS-CoV-2 Vaccines: Status Report by Amanat, Fatima, Krammer, Florian

“…SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000…”
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Transforming Growth Factor-β Signaling in Immunity and Cancer by Batlle, Eduard, Massagué, Joan

“…Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the…”
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The Immune Landscape of Cancer by Bortone, Dante S., Eddy, James A., Liu, Yuexin, Weinstein, John N., Holt, Robert A., Zenklusen, Jean C., Cho, Juok, Reynolds, Sheila, Liu, Wenbin, Ryan, Michael, Chakravarty, Debyani, Schultz, Nikolaus, Stuart, Joshua M., Wilkerson, Matthew D., Balasundaram, Miruna, Carlsen, Rebecca, Chuah, Eric, Holt, Robert, Lee, Darlene, Ha, Gavin, Schumacher, Steven E., Cope, Leslie, Balu, Saianand, Shi, Yan, Hinoue, Toshinori, Glenn, Robert, Miller, Christopher A., Curley, Erin, Mallery, David, Morris, Scott, Longatto-Filho, Adhemar, Reis, Rui M., Scapulatempo-Neto, Cristovam, Singh, Rosy, Le, Xuan, Thorp, Richard, Setdikova, Galiya, Shabunin, Alexey, Barrett, Wendi, Ostrom, Quinn T., Karlan, Beth Y., Hu, Hai, Latour, Mathieu, Lacombe, Louis, Su, Tao, Signoretti, Sabina, Marks, Jeffrey, Olson, Jeffrey J., Sica, Gabriel, Stoop, Hans, Pollo, Bianca, Aymerich, Marta, Stepa, Serghei, Moser, Catherine, Roberts, Lewis, Czerniak, Bogdan, Lazar, Alexander J., Jakrot, Valerie, Scolyer, Richard, Thompson, John, Wilmott, James, Reuter, Victor, Tien, Nguyen Viet, Park, Joong-Won, Pinto, Peter A., Moncrieff, Marc, Botnariuc, Natalia, Pirtac, Maria, Parfitt, Jeremy, Bifulco, Carlo, Antenucci, Anna, Grazi, Gianluca, Marino, Mirella, Chevalier, Simone, McKercher, Ginette, Naska, Theresa, Borgia, Jeffrey A., Pool, Mark, Junker, Kerstin, Moiseenko, Fedor, Hilty, Joe, Pilarski, Robert, Porten, Sima, Asa, Sylvia L., Schadendorf, Dirk, Disaia, Philip, Kelley, Robin K., Sifri, Suzanne, Mannelli, Massimo, Knutson, Tina, Sigmund, Rita, Postier, Russel, Walker, Joan, Feldman, Michael, Luketich, James, Rozek, Laura, Fong, Kwun M., Hooke, Jeffrey A., Govindan, Ramaswamy, Aredes, Natália D.

“…We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across…”
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COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome by Hirano, Toshio, Murakami, Masaaki

“…Zhou et al. (Nature) and Hoffmann et al. (Cell) identify ACE2 as a SARS-CoV-2 receptor, and the latter show its entry mechanism depends on cellular serine…”
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Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes by Hammond, Timothy R., Dufort, Connor, Dissing-Olesen, Lasse, Giera, Stefanie, Young, Adam, Wysoker, Alec, Walker, Alec J., Gergits, Frederick, Segel, Michael, Nemesh, James, Marsh, Samuel E., Saunders, Arpiar, Macosko, Evan, Ginhoux, Florent, Chen, Jinmiao, Franklin, Robin J.M., Piao, Xianhua, McCarroll, Steven A., Stevens, Beth

“…Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of…”
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T Follicular Helper Cell Biology: A Decade of Discovery and Diseases by Crotty, Shane

“…Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining…”
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Autophagy in inflammation, infection, and immunometabolism by Deretic, Vojo

“…Autophagy is a quality-control, metabolic, and innate immunity process. Normative autophagy affects many cell types, including hematopoietic as well as…”
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Caspases in Cell Death, Inflammation, and Disease by Van Opdenbosch, Nina, Lamkanfi, Mohamed

“…Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of…”
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The immunology of sepsis by van der Poll, Tom, Shankar-Hari, Manu, Wiersinga, W. Joost

“…Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. This recently implemented definition does not…”
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Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species by Zilionis, Rapolas, Engblom, Camilla, Pfirschke, Christina, Savova, Virginia, Zemmour, David, Saatcioglu, Hatice D., Krishnan, Indira, Maroni, Giorgia, Meyerovitz, Claire V., Kerwin, Clara M., Choi, Sun, Richards, William G., De Rienzo, Assunta, Tenen, Daniel G., Bueno, Raphael, Levantini, Elena, Pittet, Mikael J., Klein, Allon M.

“…Tumor-infiltrating myeloid cells (TIMs) comprise monocytes, macrophages, dendritic cells, and neutrophils, and have emerged as key regulators of cancer growth…”
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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms by Beltra, Jean-Christophe, Manne, Sasikanth, Abdel-Hakeem, Mohamed S., Kurachi, Makoto, Giles, Josephine R., Chen, Zeyu, Casella, Valentina, Ngiow, Shin Foong, Khan, Omar, Huang, Yinghui Jane, Yan, Patrick, Nzingha, Kito, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Wherry, E. John

“…CD8+ T cell exhaustion is a major barrier to current anti-cancer immunotherapies. Despite this, the developmental biology of exhausted CD8+ T cells (Tex)…”
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Cytokine Storms: Understanding COVID-19 by Mangalmurti, Nilam, Hunter, Christopher A.

“…The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm…”
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The IL-17 Family of Cytokines in Health and Disease by McGeachy, Mandy J., Cua, Daniel J., Gaffen, Sarah L.

“…The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this…”
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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses by Alameh, Mohamad-Gabriel, Tombácz, István, Bettini, Emily, Lederer, Katlyn, Ndeupen, Sonia, Sittplangkoon, Chutamath, Wilmore, Joel R., Gaudette, Brian T., Soliman, Ousamah Y., Pine, Matthew, Hicks, Philip, Manzoni, Tomaz B., Knox, James J., Johnson, John L., Laczkó, Dorottya, Muramatsu, Hiromi, Davis, Benjamin, Meng, Wenzhao, Rosenfeld, Aaron M., Strohmeier, Shirin, Lin, Paulo J.C., Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Jacquet, Alain, Krammer, Florian, Bates, Paul, Cancro, Michael P., Weissman, Drew, Luning Prak, Eline T., Allman, David, Igyártó, Botond Z., Locci, Michela, Pardi, Norbert

“…Adjuvants are critical for improving the quality and magnitude of adaptive immune responses to vaccination. Lipid nanoparticle (LNP)-encapsulated…”
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