Search Results - "Imlay, James A"

Where in the world do bacteria experience oxidative stress? by Imlay, James A.

“…Summary Reactive oxygen species – superoxide, hydrogen peroxide and hydroxyl radicals – have long been suspected of constraining bacterial growth in important…”
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The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium by Imlay, James A.

“…Key Points Excess oxygen can disrupt the growth of most organisms, but the underlying mechanisms of damage have proved difficult to unravel. The model…”
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The Mismetallation of Enzymes during Oxidative Stress by Imlay, James A.

“…Mononuclear iron enzymes can tightly bind non-activating metals. How do cells avoid mismetallation? The model bacterium Escherichia coli may control its metal…”
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Cellular defenses against superoxide and hydrogen peroxide by Imlay, James A

“…Life evolved in an anaerobic world; therefore, fundamental enzymatic mechanisms and biochemical pathways were refined and integrated into metabolism in the…”
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Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species by Liu, Yuanyuan, Imlay, James A.

“…Recent observations have suggested that classic antibiotics kill bacteria by stimulating the formation of reactive oxygen species (ROS). If true, this notion…”
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iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity by Macomber, Lee, Imlay, James A

“…Excess copper is poisonous to all forms of life, and copper overloading is responsible for several human pathologic processes. The primary mechanisms of…”
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How Microbes Defend Themselves From Incoming Hydrogen Peroxide by Sen, Ananya, Imlay, James A

“…Microbes rely upon iron as a cofactor for many enzymes in their central metabolic processes. The reactive oxygen species (ROS) superoxide and hydrogen peroxide…”
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Evidence for endogenous hydrogen peroxide production by E. coli fatty acyl-CoA dehydrogenase by Sirithanakorn, Chaiyos, Imlay, James A

“…Aerobic organisms continuously generate internal superoxide and hydrogen peroxide, which can damage enzymes and impair growth. To avoid this problem cells…”
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Silver(I), Mercury(II), Cadmium(II), and Zinc(II) Target Exposed Enzymic Iron-Sulfur Clusters when They Toxify Escherichia coli by FANG FANG XU, IMLAY, James A

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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SoxRS response of Escherichia coli is directly activated by redox-cycling drugs rather than by superoxide by Gu, Mianzhi, Imlay, James A

“…When Escherichia coli is exposed to redox-cycling drugs, its SoxR transcription factor is activated by oxidation of its [2Fe-2S] cluster. In aerobic cells…”
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Do reactive oxygen species or does oxygen itself confer obligate anaerobiosis? The case of Bacteroides thetaiotaomicron by Khademian, Maryam, Imlay, James A.

“…Bacteroides thetaiotaomicron was examined to determine whether its obligate anaerobiosis is imposed by endogenous reactive oxygen species or by molecular…”
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Iron enzyme ribulose-5-phosphate 3-epimerase in Escherichia coli is rapidly damaged by hydrogen peroxide but can be protected by manganese by Sobota, Jason M., Imlay, James A., Fridovich, Irwin

“…H₂O₂ is commonly generated in biological habitats by environmental chemistry and by cellular immune responses. H₂O₂ penetrates cells, disrupts metabolism, and…”
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Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli by Anjem, Adil, Varghese, Shery, Imlay, James A

“…Very little manganese is imported into Escherichia coli under routine growth conditions: the import system is weakly expressed, the manganese content is low,…”
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Two sources of endogenous hydrogen peroxide in Escherichia coli by Korshunov, Sergei, Imlay, James A.

“…Summary Mechanisms of hydrogen peroxide generation in Escherichia coli were investigated using a strain lacking scavenging enzymes. Surprisingly, the deletion…”
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Micromolar Intracellular Hydrogen Peroxide Disrupts Metabolism by Damaging Iron-Sulfur Enzymes by Jang, Soojin, Imlay, James A.

“…An Escherichia coli strain that cannot scavenge hydrogen peroxide has been used to identify the cell processes that are most sensitive to this oxidant. Low…”
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PATHWAYS OF OXIDATIVE DAMAGE by Imlay, James A

“…The phenomenon of oxygen toxicity is universal, but only recently have we begun to understand its basis in molecular terms. Redox enzymes are notoriously…”
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Superoxide poisons mononuclear iron enzymes by causing mismetallation by Gu, Mianzhi, Imlay, James A.

“…Summary Superoxide (O2−) is a primary agent of intracellular oxidative stress. Genetic studies in many organisms have confirmed that excess O2− disrupts…”
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The induction of two biosynthetic enzymes helps Escherichia coli sustain heme synthesis and activate catalase during hydrogen peroxide stress by Mancini, Stefano, Imlay, James A.

“…Summary Hydrogen peroxide pervades many natural environments, including the phagosomes that mediate cell‐based immunity. Transcriptomic analysis showed that…”
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An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide by Mishra, Surabhi, Imlay, James A.

“…Summary Obligate anaerobes are periodically exposed to oxygen, and it has been conjectured that on such occasions their low‐potential biochemistry will…”
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Intracellular Copper Does Not Catalyze the Formation of Oxidative DNA Damage in Escherichia coli by MACOMBER, Lee, RENSING, Christopher, IMLAY, James A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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