Search Results - "Imig, John D."

Eicosanoid blood vessel regulation in physiological and pathological states by Imig, John D

“…Arachidonic acid can be metabolized in blood vessels by three primary enzymatic pathways; cyclooxygenase (COX), lipoxygenase (LO), and cytochrome P450 (CYP)…”
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Epoxides and soluble epoxide hydrolase in cardiovascular physiology by Imig, John D

“…Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to…”
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SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection by Imig, John D

“…The SARS-CoV-2 virus that results in COVID-19 has been found to damage multiple organs beyond the lung. Interestingly, the SARS-CoV-2 spike (S) protein can be…”
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Peroxisome proliferator-activated receptors, farnesoid X receptor, and dual modulating drugs in hypertension by Imig, John D

“…Hypertension characterized by an elevated blood pressure is a cardiovascular disease that afflicts greater than one in every three adults worldwide. Nuclear…”
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Editorial: The future of physiology: 2020 and beyond, Volume III by Imig, John D

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Frontiers in metabolic physiology grand challenges by Imig, John D

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Multi-Target Approaches in Metabolic Syndrome by Lillich, Felix F, Imig, John D, Proschak, Ewgenij

“…Metabolic syndrome (MetS) is a highly prevalent disease cluster worldwide. It requires polypharmacological treatment of the single conditions including type II…”
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Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet by Mohamed, Islam N., Hafez, Sherif S., Fairaq, Arwa, Ergul, Adviye, Imig, John D., El-Remessy, Azza B.

“…Aims/hypothesis Obesity and hypertension, known pro-inflammatory states, are identified determinants for increased retinal microvascular abnormalities…”
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Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors by Imig, John D, Morisseau, Christophe

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Diabetes risk associated with plasma epoxylipid levels by Imig, John D.

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Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases by Imig, John D

“…Renal epoxygenase metabolites are involved in blood flow regulation and long-term blood pressure control. One feature of renal and cardiovascular diseases is…”
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Epoxyeicosatrienoic acids, hypertension, and kidney injury by Imig, John D

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Dual soluble epoxide hydrolase inhibitor - farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis by Khan, Md Abdul Hye, Nolan, Benjamin, Stavniichuk, Anna, Merk, Daniel, Imig, John D

“…Renal fibrosis associated with inflammation is a critical pathophysiological event in chronic kidney disease (CKD). We have developed DM509 which acts…”
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Editorial: Nuclear receptors in hemodynamics and blood pressure control by Imig, John D, Wu, Jing, Gohar, Eman Y

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Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences by Goorani, Samaneh, Khan, Abdul Hye, Mishra, Abhishek, El-Meanawy, Ashraf, Imig, John D.

“…Abstract Introduction: Renal fibrosis is a critical event in the development and progression of chronic kidney disease (CKD), and it is considered the final…”
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Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance by Luria, Ayala, Bettaieb, Ahmed, Xi, Yannan, Shieh, Guang-Jong, Liu, Hsin-Chen, Inoue, Hiromi, Tsai, Hsing-Ju, Imig, John D, Haj, Fawaz G, Hammock, Bruce D

“…Visceral obesity has been defined as an important element of the metabolic syndrome and contributes to the development of insulin resistance and cardiovascular…”
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Editorial: Interactions Between Podocytes, Mesangial Cells, and Glomerular Endothelial Cells in Glomerular Diseases by Imig, John D, Zhao, Xueying, Elmarakby, Ahmed A, Pavlov, Tengis

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Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats by Elmarakby, Ahmed A, Imig, John D

“…Obesity and hypertension are the two major risk factors that contribute to the progression of end-stage renal disease. To examine whether hypertension further…”
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Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity by Imig, John D, Hye Khan, Md Abdul, Burkhan, Anna, Chen, Guan, Adebesin, Adeniyi Michael, Falck, John R

“…Although epoxyeicosatrienoic acid (EET) analogs have performed well in several acute and chronic kidney disease models, targeted delivery of EET analogs to the…”
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Eicosanoids and renal vascular function in diseases by Imig, John D

“…Arachidonic acid metabolites are vital for the proper control of renal haemodynamics and, when not properly controlled, can contribute to renal vascular injury…”
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