Search Results - "Imig, John"

Prospective for cytochrome P450 epoxygenase cardiovascular and renal therapeutics by Imig, John D.

“…Therapeutics for arachidonic acid pathways began with the development of non-steroidal anti-inflammatory drugs that inhibit cyclooxygenase (COX). The enzymatic…”
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Eicosanoid blood vessel regulation in physiological and pathological states by Imig, John D

“…Arachidonic acid can be metabolized in blood vessels by three primary enzymatic pathways; cyclooxygenase (COX), lipoxygenase (LO), and cytochrome P450 (CYP)…”
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SARS-CoV-2 spike protein causes cardiovascular disease independent of viral infection by Imig, John D

“…The SARS-CoV-2 virus that results in COVID-19 has been found to damage multiple organs beyond the lung. Interestingly, the SARS-CoV-2 spike (S) protein can be…”
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Epoxides and soluble epoxide hydrolase in cardiovascular physiology by Imig, John D

“…Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to…”
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Epoxylipids and soluble epoxide hydrolase in heart diseases by Imig, John D., Cervenka, Ludek, Neckar, Jan

“…[Display omitted] Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary artery endothelial and vascular dysfunction,…”
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Bioactive lipids in hypertension by Imig, John D

“…Hypertension is a major healthcare issue that afflicts one in every three adults worldwide and contributes to cardiovascular diseases, morbidity and mortality…”
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Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases by Imig, John D, Hammock, Bruce D

“…Key Points Many of the enzymes, receptors and eicosanoid metabolites of the arachidonate cascade are important therapeutic targets, particularly for…”
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Peroxisome proliferator-activated receptors, farnesoid X receptor, and dual modulating drugs in hypertension by Imig, John D

“…Hypertension characterized by an elevated blood pressure is a cardiovascular disease that afflicts greater than one in every three adults worldwide. Nuclear…”
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Editorial: The future of physiology: 2020 and beyond, Volume III by Imig, John D

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Orally active epoxyeicosatrienoic acid analogs in hypertension and renal injury by Imig, John D

“…Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites synthesized by cytochrome P450 epoxygenases. Biological activities for EETs include…”
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Frontiers in metabolic physiology grand challenges by Imig, John D

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Multi-Target Approaches in Metabolic Syndrome by Lillich, Felix F, Imig, John D, Proschak, Ewgenij

“…Metabolic syndrome (MetS) is a highly prevalent disease cluster worldwide. It requires polypharmacological treatment of the single conditions including type II…”
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Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function by Imig, John D.

“…► 20-HETE constricts afferent arterioles and contributes to autoregulation. ► EETs dilate afferent arterioles and act as an EDHF. ► 20-HETE and EETs contribute…”
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Epigenetic soluble epoxide hydrolase regulation causes endothelial dysfunction by Imig, John D.

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Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture by Imig, John D., Jankiewicz, Wojciech K., Khan, Abdul H.

“…Epoxyeicosatrienoic acids (EETs) are epoxy fatty acids that have biological actions that are essential for maintaining water and electrolyte homeostasis. An…”
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Osteopontin Regulates Phosphate Solubility to Prevent Mineral Aggregates in CKD by Imig, John D

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Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet by Mohamed, Islam N., Hafez, Sherif S., Fairaq, Arwa, Ergul, Adviye, Imig, John D., El-Remessy, Azza B.

“…Aims/hypothesis Obesity and hypertension, known pro-inflammatory states, are identified determinants for increased retinal microvascular abnormalities…”
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Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors by Imig, John D, Morisseau, Christophe

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Diabetes risk associated with plasma epoxylipid levels by Imig, John D.

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Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases by Imig, John D

“…Renal epoxygenase metabolites are involved in blood flow regulation and long-term blood pressure control. One feature of renal and cardiovascular diseases is…”
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