Search Results - "Imbimbo, Bruno Pietro"

Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease? by Vecchio, Filomena Lo, Bisceglia, Paola, Imbimbo, Bruno Pietro, Lozupone, Madia, Latino, Raffaela Rita, Resta, Emanuela, Leone, Maurizio, Solfrizzi, Vincenzo, Greco, Antonio, Daniele, Antonio, Watling, Mark, Panza, Francesco, Seripa, Davide

“…Human apolipoprotein E (ApoE) is a 299-amino acid secreted glycoprotein that binds cholesterol and phospholipids. ApoE exists as three common isoforms (ApoE2,…”
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Editorial: Neurotrophins Biodelivery to CNS: Innovative Approaches for Disease-Modifying Therapy by Triaca, Viviana, Imbimbo, Bruno Pietro, Nisticò, Robert

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Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors by Zanotti, Giuseppe, Cendron, Laura, Folli, Claudia, Florio, Paola, Imbimbo, Bruno Pietro, Berni, Rodolfo

“…•An acidic pH-induced large conformational change affects the amyloidogenic I84S TTR.•CHF5074 and diflunisal bind to T4 sites of TTR, inhibiting…”
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Liver fibrosis score, physical frailty, and the risk of dementia in older adults: The Italian Longitudinal Study on Aging by Solfrizzi, Vincenzo, Scafato, Emanuele, Custodero, Carlo, Loparco, Francesca, Ciavarella, Alessandro, Panza, Francesco, Seripa, Davide, Imbimbo, Bruno Pietro, Lozupone, Madia, Napoli, Nicola, Piazzolla, Giuseppina, Galluzzo, Lucia, Gandin, Claudia, Baldereschi, Marzia, Di Carlo, Antonio, Inzitari, Domenico, Pilotto, Alberto, Sabbà, Carlo

“…Introduction Liver fibrosis increases progressively with aging and has been associated with poorer cognitive performance in middle‐aged and older adults. We…”
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Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation by Porrini, Vanessa, Sarnico, Ilenia, Benarese, Marina, Branca, Caterina, Mota, Mariana, Lanzillotta, Annamaria, Bellucci, Arianna, Parrella, Edoardo, Faggi, Lara, Spano, Pierfranco, Imbimbo, Bruno Pietro, Pizzi, Marina

“…CSP-1103 (formerly CHF5074) has been shown to reverse memory impairment and reduce amyloid plaque as well as inflammatory microglia activation in preclinical…”
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Use of Donanemab in Early Symptomatic Alzheimer Disease by Pomara, Nunzio, Imbimbo, Bruno Pietro

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Do anti‐Aβ monoclonal antibodies lower brain plaques in Alzheimer patients through microglia activation? by Pomara, Nunzio, Imbimbo, Bruno Pietro

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Brain Amyloid Deposition in Late-Life Depression by Pomara, Nunzio, Imbimbo, Bruno Pietro

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Microglia-mediated neuroimmune suppression in posttraumatic stress disorder by Pomara, Nunzio, Osorio, Ricardo, Reichert Plaska, Chelsea, Imbimbo, Bruno Pietro

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The β-Secretase BACE1 in Alzheimer’s Disease by Hampel, Harald, Vassar, Robert, De Strooper, Bart, Hardy, John, Willem, Michael, Singh, Neeraj, Zhou, John, Yan, Riqiang, Vanmechelen, Eugeen, De Vos, Ann, Nisticò, Robert, Corbo, Massimo, Imbimbo, Bruno Pietro, Streffer, Johannes, Voytyuk, Iryna, Timmers, Maarten, Tahami Monfared, Amir Abbas, Irizarry, Michael, Albala, Bruce, Koyama, Akihiko, Watanabe, Naoto, Kimura, Teiji, Yarenis, Lisa, Lista, Simone, Kramer, Lynn, Vergallo, Andrea

“…BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all…”
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Should drug discovery scientists still embrace the amyloid hypothesis for Alzheimer's disease or should they be looking elsewhere? by Imbimbo, Bruno Pietro, Ippati, Stefania, Watling, Mark

“…Alzheimer's Disease (AD) represents a large and growing challenge to patients, carers and healthcare systems, yet extensive efforts to develop therapeutics to…”
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Do anti-amyloid-β drugs affect neuropsychiatric status in Alzheimer's disease patients? by Panza, Francesco, Lozupone, Madia, Bellomo, Antonello, Imbimbo, Bruno Pietro

“…In the Alzheimer's disease (AD) brain, accumulation of the amyloid-β (Aβ) peptide starts 15-20 years before clinical symptoms become apparent and is believed…”
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Use of Donanemab in Early Symptomatic Alzheimer Disease / Reply by Pomara, Nunzio, Imbimbo, Bruno Pietro, Evans, Cynthia D, Sims, John R

“…Pomara and Imbimbo comment on the study on the use of donanemab in early symptomatic Alzheimer disease. The TRAILBLAZER-ALZ 2 trial 1 provided additional…”
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Can platelet activation result in increased plasma Aβ levels and contribute to the pathogenesis of Alzheimer’s disease? by Carbone, Manuel Glauco, Pagni, Giovanni, Tagliarini, Claudia, Imbimbo, Bruno Pietro, Pomara, Nunzio

“…[Display omitted] •Alzheimer’s disease (AD) is pathologically characterized by deposits of amyloid-β (Aβ) and by aggregates of hyperphosphorylated tau…”
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Molecular mechanisms of skin wound healing in non-diabetic and diabetic mice in excision and pressure experimental wounds by Baldassarro, Vito Antonio, Lorenzini, Luca, Giuliani, Alessandro, Cescatti, Maura, Alastra, Giuseppe, Pannella, Micaela, Imbimbo, Bruno Pietro, Villetti, Gino, Calzà, Laura, Giardino, Luciana

“…Experimental models for chronic skin lesions are excision and pressure ulcer, defined as “open” and “closed” lesions, respectively, only the latter…”
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Does the imbalance in the apolipoprotein E isoforms underlie the pathophysiological process of sporadic Alzheimer's disease? by Lozupone, Madia, Imbimbo, Bruno Pietro, Balducci, Claudia, Lo Vecchio, Filomena, Bisceglia, Paola, Latino, Raffaela Rita, Leone, Maurizio, Dibello, Vittorio, Solfrizzi, Vincenzo, Greco, Antonio, Daniele, Antonio, Watling, Mark, Seripa, Davide, Panza, Francesco

“…Human apolipoprotein E (apoE) is a 299‐amino acid secreted glycoprotein binding cholesterol and phospholipids, and with three common isoforms (APOE ε2, APOE…”
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A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia by Latini, Laura, De Araujo, Daniel Souza Monteiro, Amato, Rosario, Canovai, Alessio, Buccarello, Lucia, De Logu, Francesco, Novelli, Elena, Vlasiuk, Anastasiia, Malerba, Francesca, Arisi, Ivan, Florio, Rita, Asari, Hiroki, Capsoni, Simona, Strettoi, Enrica, Villetti, Gino, Imbimbo, Bruno Pietro, Dal Monte, Massimo, Nassini, Romina, Geppetti, Pierangelo, Marinelli, Silvia, Cattaneo, Antonino

“…Background and Purpose Retinal ganglion cells (RGCs) are the output stage of retinal information processing, via their axons forming the optic nerve (ON). ON…”
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Type 2 Diabetes Mellitus, Platelet Activation and Alzheimer’s Disease: A Possible Connection by Carbone, Manuel Glauco, Pomara, Nunzio, Callegari, Camilla, Marazziti, Donatella, Imbimbo, Bruno Pietro

“…Type 2 diabetes mellitus DM (T2DM) is associated with a 70% increased risk for dementia, including Alzheimer’s disease (AD). Insulin resistance has been…”
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Examination of level of knowledge in Italian general practitioners attending an education session on diagnosis and management of the early stage of Alzheimer's disease: pass or fail? by Veneziani, Federica, Panza, Francesco, Solfrizzi, Vincenzo, Capozzo, Rosa, Barulli, Maria Rosaria, Leo, Antonio, Lozupone, Madia, Fontana, Andrea, Arcuti, Simona, Copetti, Massimiliano, Cardinali, Valentina, Grasso, Alessandra, Tursi, Marianna, Iurillo, Annalisa, Imbimbo, Bruno Pietro, Seripa, Davide, Logroscino, Giancarlo

“…We detected the general level of knowledge about the early diagnosis of Alzheimer's disease (AD) and subsequent care in general practitioners (GPs) from…”
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Pharmacological targeting of the β-amyloid precursor protein intracellular domain by Branca, Caterina, Sarnico, Ilenia, Ruotolo, Roberta, Lanzillotta, Annamaria, Viscomi, Arturo Roberto, Benarese, Marina, Porrini, Vanessa, Lorenzini, Luca, Calzà, Laura, Imbimbo, Bruno Pietro, Ottonello, Simone, Pizzi, Marina

“…Amyloid precursor protein (APP) intracellular domain (AICD) is a product of APP processing with transcriptional modulation activity, whose overexpression…”
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