Search Results - "Imarisio, S"

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity by Menzies, F M, Garcia-Arencibia, M, Imarisio, S, O'Sullivan, N C, Ricketts, T, Kent, B A, Rao, M V, Lam, W, Green-Thompson, Z W, Nixon, R A, Saksida, L M, Bussey, T J, O'Kane, C J, Rubinsztein, D C

“…Over recent years, accumulated evidence suggests that autophagy induction is protective in animal models of a number of neurodegenerative diseases. Intense…”
Get full text

α-Helix targeting reduces amyloid-β peptide toxicity by Nerelius, C, Sandegren, A, Sargsyan, H, Raunak, R, Leijonmarck, H, Chatterjee, U, Fisahn, A, Imarisio, S, Lomas, D.A, Crowther, D.C, Strömberg, R, Johansson, J

“…The amyloid-β peptide (Aβ) can generate cytotoxic oligomers, and their accumulation is thought to underlie the neuropathologic changes found in Alzheimer's…”
Get full text

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease by Underwood, Benjamin R., Imarisio, Sara, Fleming, Angeleen, Rose, Claudia, Krishna, Gauri, Heard, Phoebe, Quick, Marie, Korolchuk, Viktor I., Renna, Maurizio, Sarkar, Sovan, García-Arencibia, Moisés, O'Kane, Cahir J., Murphy, Michael P., Rubinsztein, David C.

“…Many neurodegenerative diseases exhibit protein accumulation and increased oxidative stress. Therapeutic strategies include clearing aggregate-prone proteins…”
Get full text

Developing a transgenic marker to research Huntington's disease in Drosophila melanogaster by Rodney, Simon, Imarisio, S

Get full text

Defective Neurogenesis in Citron Kinase Knockout Mice by Altered Cytokinesis and Massive Apoptosis by Di Cunto, Ferdinando, Imarisio, Sara, Hirsch, Emilio, Broccoli, Vania, Bulfone, Alessandro, Migheli, Antonio, Atzori, Cristiana, Turco, Emilia, Triolo, Roberta, Dotto, Gian Paolo, Silengo, Lorenzo, Altruda, Fiorella

“…Citron-kinase (Citron-K) has been proposed by in vitro studies as a crucial effector of Rho in regulation of cytokinesis. To further investigate in vivo its…”
Get full text

Lithium induces autophagy by inhibiting inositol monophosphatase by Sarkar, Sovan, Floto, R. Andres, Berger, Zdenek, Imarisio, Sara, Cordenier, Axelle, Pasco, Matthieu, Cook, Lynnette J, Rubinsztein, David C

“…Macroautophagy is a key pathway for the clearance of aggregate-prone cytosolic proteins. Currently, the only suitable pharmacologic strategy for up-regulating…”
Get full text

Dynein mutations impair autophagic clearance of aggregate-prone proteins by Rubinsztein, David C, Ravikumar, Brinda, Acevedo-Arozena, Abraham, Imarisio, Sara, Berger, Zdenek, Vacher, Coralie, O'Kane, Cahir J, Brown, Steve D M

“…Mutations that affect the dynein motor machinery are sufficient to cause motor neuron disease. It is not known why there are aggregates or inclusions in…”
Get full text

Drosophila citron kinase is required for the final steps of cytokinesis by Naim, Valeria, Imarisio, Sara, Di Cunto, Ferdinando, Gatti, Maurizio, Bonaccorsi, Silvia

“…The mechanisms underlying completion of cytokinesis are still poorly understood. Here, we show that the Drosophila orthologue of mammalian Citron kinases is…”
Get full text

Dyneins, Autophagy, Aggregation and Neurodegeneration by Rubinsztein, David C., Ravikumar, Brinda, Acevedo-Arozena, Abraham, Imarisio, Sara, O'Kane, Cahir J., Brown, Steve D.M.

“…We recently showed that the dynein motor machinery plays a role in the delivery of autophagosome contents to lysosomes, in the process of…”
Get full text

[alpha]-Helix targeting reduces amyloid-[beta] peptide toxicity by Nerelius, C, Sandegren, A, Sargsyan, H, Raunak, R, Leijonmarck, H, Chatterjee, U, Fisahn, A, Imarisio, S, Lomas, D A, Crowther, D C, Strömberg, R, Johansson, J

“…The amyloid-β peptide (Aβ) can generate cytotoxic oligomers, and their accumulation is thought to underlie the neuropathologic changes found in Alzheimer's…”
Get full text

α-Helix targeting reduces amyloid-β peptide toxicity by Nerelius, C, Sandegren, A, Sargsyan, H, Raunak, R, Leijonmarck, H, Chatterjee, U, Fisahn, A, Imarisio, S, Lomas, D.A, Crowther, D.C, Strömberg, R, Johansson, J

“…The amyloid-β peptide (Aβ) can generate cytotoxic oligomers, and their accumulation is thought to underlie the neuropathologic changes found in Alzheimer's…”
Get full text

α-Helix Targeting Reduces Amyloid-ß Peptide Toxicity by Nerelius, C., Sandegren, A., Sargsyan, H., Raunak, R., Leijonmarck, H., Chatterjee, U., Fisahn, A., Imarisio, S., Lomas, D. A., Crowther, D. C., Strömberg, R., Johansson, J., Gustafsson, Jan-Ake

“…The amyloid-ß peptide (Aß) can generate cytotoxic oligomers, and their accumulation is thought to underlie the neuropathologic changes found in Alzheimer's…”
Get full text

Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation by Dotti, Carlos G, Di Cunto, Ferdinando, Camera, Paola, Da Silva, Jorge Santos, Griffiths, Gareth, Giuffrida, Maria Gabriella, Ferrara, Luciana, Schubert, Vanessa, Imarisio, Sara, Silengo, Lorenzo

“…The actin cytoskeleton is best known for its role during cellular morphogenesis. However, other evidence suggests that actin is also crucial for the…”
Get full text

Essential role of citron kinase in cytokinesis of spermatogenic precursors by Cunto, Ferdinando Di, Imarisio, Sara, Camera, Paola, Boitani, Carla, Altruda, Fiorella, Silengo, Lorenzo

“…During spermatogenesis, the first morphological indication of spermatogonia differentiation is incomplete cytokinesis, followed by the assembly of stable…”
Get full text

pAkt, Cyclin D1 and p27/Kip.1 in Glioblastomas With and Without EGFR Amplification and PTEN Mutation by FIANO, Valentina, GHIMENTI, Chiara, IMARISIO, Sara, SILENGO, Lorenzo, SCHIFFER, Davide

“…Background: PIP3, generated by PI3-K, activates Akt which inactivates AFX/FKHR, with the consequent decrease in p27/Kip.1 expression and enhancement of cyclin…”
Get full text

Role of citron kinase in dendritic morphogenesis of cortical neurons by Di Cunto, Ferdinando, Ferrara, Luciana, Curtetti, Roberta, Imarisio, Sara, Guazzone, Simona, Broccoli, Vania, Bulfone, Alessandro, Altruda, Fiorella, Vercelli, Alessandro, Silengo, Lorenzo

“…Small GTPases of the rho family regulate the extensive rearrangements of the cytoskeleton that characterize neuronal differentiation. Citron kinase is a target…”
Get full text