Search Results - "Imanishi, Y."

Interphase phosphorylation of lamin A by Kochin, Vitaly, Shimi, Takeshi, Torvaldson, Elin, Adam, Stephen A, Goldman, Anne, Pack, Chan-Gi, Melo-Cardenas, Johanna, Imanishi, Susumu Y, Goldman, Robert D, Eriksson, John E

“…Nuclear lamins form the major structural elements that comprise the nuclear lamina. Loss of nuclear structural integrity has been implicated as a key factor in…”
Get full text

Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 by Kauko, Otto, Imanishi, Susumu Y., Kulesskiy, Evgeny, Yetukuri, Laxman, Laajala, Teemu Daniel, Sharma, Mukund, Pavic, Karolina, Aakula, Anna, Rupp, Christian, Jumppanen, Mikael, Haapaniemi, Pekka, Ruan, Luyao, Yadav, Bhagwan, Suni, Veronika, Varila, Taru, Corthals, Garry L., Reimand, Jüri, Wennerberg, Krister, Aittokallio, Tero, Westermarck, Jukka

“…Protein phosphatase 2A (PP2A) critically regulates cell signaling and is a human tumor suppressor. PP2A complexes are modulated by proteins such as cancerous…”
Get full text

Optimization of TripleTOF spectral simulation and library searching for confident localization of phosphorylation sites by Takai, Ayano, Tsubosaka, Tomoya, Hirano, Yasuhiro, Hayakawa, Naoki, Tani, Fumitaka, Haapaniemi, Pekka, Suni, Veronika, Imanishi, Susumu Y

“…Tandem mass spectrometry (MS/MS) has been used in analysis of proteins and their post-translational modifications. A recently developed data analysis method,…”
Get full text

Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function by Virtakoivu, Reetta, Mai, Anja, Mattila, Elina, De Franceschi, Nicola, Imanishi, Susumu Y, Corthals, Garry, Kaukonen, Riina, Saari, Markku, Cheng, Fang, Torvaldson, Elin, Kosma, Veli-Matti, Mannermaa, Arto, Muharram, Ghaffar, Gilles, Christine, Eriksson, John, Soini, Ylermi, Lorens, James B, Ivaska, Johanna

“…Epithelial-mesenchymal transition (EMT) in cells is a developmental process adopted during tumorigenesis that promotes metastatic capacity. In this study, we…”
Get full text

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages by Söderholm, Sandra, Kainov, Denis E., Öhman, Tiina, Denisova, Oxana V., Schepens, Bert, Kulesskiy, Evgeny, Imanishi, Susumu Y., Corthals, Garry, Hintsanen, Petteri, Aittokallio, Tero, Saelens, Xavier, Matikainen, Sampsa, Nyman, Tuula A.

“…Influenza A viruses cause infections in the human respiratory tract and give rise to annual seasonal outbreaks, as well as more rarely dreaded pandemics…”
Get full text

SimPhospho: a software tool enabling confident phosphosite assignment by Suni, Veronika, Suomi, Tomi, Tsubosaka, Tomoya, Imanishi, Susumu Y, Elo, Laura L, Corthals, Garry L

“…Abstract Motivation Mass spectrometry combined with enrichment strategies for phosphorylated peptides has been successfully employed for two decades to…”
Get full text

Impaired residual renal function predicts denosumab-induced serum calcium decrement as well as increment of bone mineral density in non-severe renal insufficiency by Miyaoka, D., Imanishi, Y., Ohara, M., Hayashi, N., Nagata, Y., Yamada, S., Mori, K., Emoto, M., Inaba, M.

“…Summary Denosumab treatment of osteoporotic patients, except those with severe renal insufficiency, reduced cCa levels. Low baseline cCa, low estimated…”
Get full text

Increased undercarboxylated osteocalcin/intact osteocalcin ratio in patients undergoing hemodialysis by Nagata, Y., Inaba, M., Imanishi, Y., Okazaki, H., Yamada, S., Mori, K., Shoji, S., Koyama, H., Okuno, S.

“…Summary Serum undercarboxylated osteocalcin (ucOC)/intact osteocalcin (iOC) ratio increased >1.0 in the patients undergoing hemodialysis, particularly in those…”
Get full text

Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF SF autocrine pathway by HU, B, GUO, P, BAR-JOSEPH, I, IMANISHI, Y, JARZYNKA, M. J, BOGLER, O, MIKKELSEN, T, HIROSE, T, NISHIKAWA, R, CHENG, S. Y

“…Neuropilin-1 (NRP1) functions as a coreceptor through interaction with plexin A1 or vascular endothelial growth factor (VEGF) receptor during neuronal…”
Get full text

Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells by Lindqvist, Julia, Imanishi, Susumu Y, Torvaldson, Elin, Malinen, Marjo, Remes, Mika, Örn, Fanny, Palvimo, Jorma J, Eriksson, John E

“…Contrary to cell cycle-associated cyclin-dependent kinases, CDK5 is best known for its regulation of signaling processes in differentiated cells and its…”
Get full text

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells by Santio, Niina M, Landor, Sebastian K-J, Vahtera, Laura, Ylä-Pelto, Jani, Paloniemi, Elina, Imanishi, Susumu Y, Corthals, Garry, Varjosalo, Markku, Manoharan, Ganesh Babu, Uri, Asko, Lendahl, Urban, Sahlgren, Cecilia, Koskinen, Päivi J

“…Tumorigenesis is a multistep process involving co-operation between several deregulated oncoproteins. In this study, we unravel previously unrecognized…”
Get full text

Confident Site Localization Using a Simulated Phosphopeptide Spectral Library by Suni, Veronika, Imanishi, Susumu Y, Maiolica, Alessio, Aebersold, Ruedi, Corthals, Garry L

“…We have investigated if phosphopeptide identification and simultaneous site localization can be achieved by spectral library searching. This allows taking…”
Get full text

Quantitative Site-Specific Phosphoproteomics of Trichoderma reesei Signaling Pathways upon Induction of Hydrolytic Enzyme Production by Nguyen, Elizabeth V, Imanishi, Susumu Y, Haapaniemi, Pekka, Yadav, Avinash, Saloheimo, Markku, Corthals, Garry L, Pakula, Tiina M

“…The filamentous fungus Trichoderma reesei is used for industrial production of secreted enzymes including carbohydrate active enzymes, such as cellulases and…”
Get full text

Sphingolipids inhibit vimentin-dependent cell migration by Hyder, Claire L, Kemppainen, Kati, Isoniemi, Kimmo O, Imanishi, Susumu Y, Goto, Hidemasa, Inagaki, Masaki, Fazeli, Elnaz, Eriksson, John E, Törnquist, Kid

“…The sphingolipids, sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC), can induce or inhibit cellular migration. The intermediate filament…”
Get full text

Autologous Transplantation of Adipose Tissue‐Derived Stromal Cells Ameliorates Pulmonary Emphysema by Shigemura, N., Okumura, M., Mizuno, S., Imanishi, Y., Nakamura, T., Sawa, Y.

“…Adipose tissue is a useful tool for management of most complex cardiothoracic problems, including the reinforcement of damaged lungs, and adipose…”
Get full text

In Vivo Identification of Sumoylation Sites by a Signature Tag and Cysteine-targeted Affinity Purification by Blomster, Henri A., Imanishi (今西進), Susumu Y., Siimes, Jenny, Kastu, Juha, Morrice, Nick A., Eriksson, John E., Sistonen, Lea

“…Small ubiquitin-like modifier (SUMO) is conjugated to its substrates via an enzymatic cascade consisting of three enzymes, E1, E2, and E3. The active site of…”
Get full text

Application of MALDI Biotyper to cyanobacterial profiling by Imanishi, Susumu Y., Nakayama, Takuma, Asukabe, Hirohiko, Harada, Ken‐ichi

“…Rationale Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS) has been used for bacterial profiling. A few reports have…”
Get full text

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner by Sjöqvist, Marika, Antfolk, Daniel, Ferraris, Saima, Rraklli, Vilma, Haga, Cecilia, Antila, Christian, Mutvei, Anders, Imanishi, Susumu Y, Holmberg, Johan, Jin, Shaobo, Eriksson, John E, Lendahl, Urban, Sahlgren, Cecilia

“…Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is…”
Get full text

A novel missense mutation of the STS gene in two siblings with X‐linked ichthyosis, complicated by short stature, bone density reduction, epilepsy, and cryptorchidism by Ohyama, A., Nakano, H., Imanishi, Y., Seto, T., Tsuruta, D., Fukai, K.

Get full text

Role of fibroblast growth factor-23 in peripheral vascular calcification in non-diabetic and diabetic hemodialysis patients by INABA, M, OKUNO, S, IMANISHI, Y, YAMADA, S, SHIOI, A, YAMAKAWA, T, ISHIMURA, E, NISHIZAWA, Y

“…Fibroblast growth factor (FGF) 23 is a recently identified circulating factor that regulates phosphate (Pi) metabolism. Since the derangement of Pi control is…”
Get full text