Search Results - "Imamura, Riyo"

Application of Acoustic Ejection MS System to High-Throughput Screening for SARS-CoV-2 3CL Protease Inhibitors by Hasegawa, Tsukasa, Imamura, Riyo M., Suzuki, Tateki, Hashiguchi, Takao, Nomura, Takao, Otsuguro, Satoko, Maenaka, Katsumi, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko, Okabe, Takayoshi, Nagano, Tetsuo, Kojima, Hirotatsu

“…MS is a powerful methodology for chemical screening to directly quantify substrates and products of enzymes, but its low throughput has been an issue…”
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p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming by Saito, Tetsuya, Ichimura, Yoshinobu, Taguchi, Keiko, Suzuki, Takafumi, Mizushima, Tsunehiro, Takagi, Kenji, Hirose, Yuki, Nagahashi, Masayuki, Iso, Tetsuro, Fukutomi, Toshiaki, Ohishi, Maki, Endo, Keiko, Uemura, Takefumi, Nishito, Yasumasa, Okuda, Shujiro, Obata, Miki, Kouno, Tsuguka, Imamura, Riyo, Tada, Yukio, Obata, Rika, Yasuda, Daisuke, Takahashi, Kyoko, Fujimura, Tsutomu, Pi, Jingbo, Lee, Myung-Shik, Ueno, Takashi, Ohe, Tomoyuki, Mashino, Tadahiko, Wakai, Toshifumi, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Motohashi, Hozumi, Waguri, Satoshi, Soga, Tomoyoshi, Yamamoto, Masayuki, Tanaka, Keiji, Komatsu, Masaaki

“…p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that is degraded by autophagy. Amplification of the p62/Sqstm1 gene, and…”
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Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line by Yasuda, Daisuke, Ohe, Tomoyuki, Takahashi, Kyoko, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Ichimura, Yoshinobu, Komatsu, Masaaki, Yamamoto, Masayuki, Nagano, Tetsuo, Mashino, Tadahiko

“…Resistance to anticancer agents has been an obstacle to developing therapeutics and reducing medical costs. Whereas sorafenib is used for the treatment of…”
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Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library by Nurkanto, Arif, Imamura, Riyo, Rahmawati, Yulia, Prabandari, Erwahyuni Endang, Waluyo, Danang, Annoura, Takeshi, Yamamoto, Kazuki, Sekijima, Masakazu, Nishimura, Yuki, Okabe, Takayoshi, Shiba, Tomoo, Shibata, Norio, Kojima, Hirotatsu, Duffy, James, Nozaki, Tomoyoshi

“…Malaria is a mosquito-borne fatal infectious disease that affects humans and is caused by parasites, primarily Plasmodium falciparum. Widespread drug…”
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Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin by Hitsumoto, Tatsuro, Tsukamoto, Osamu, Matsuoka, Ken, Li, Junjun, Liu, Li, Kuramoto, Yuki, Higo, Shuichiro, Ogawa, Shou, Fujino, Noboru, Yoshida, Shohei, Kioka, Hidetaka, Kato, Hisakazu, Hakui, Hideyuki, Saito, Yuki, Okamoto, Chisato, Inoue, Hijiri, Hyejin, Jo, Ueda, Kyoko, Segawa, Takatsugu, Nishimura, Shunsuke, Asano, Yoshihiro, Asanuma, Hiroshi, Tani, Akiyoshi, Imamura, Riyo, Komagawa, Shinsuke, Kanai, Toshio, Takamura, Masayuki, Sakata, Yasushi, Kitakaze, Masafumi, Haruta, Jun-ichi, Takashima, Seiji

“…Cardiac-specific myosin light chain kinase (cMLCK), encoded by , regulates cardiac contractility through phosphorylation of ventricular myosin regulatory light…”
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Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti by Inaba, Kazue, Ebihara, Kana, Senda, Miki, Yoshino, Ryunosuke, Sakuma, Chisako, Koiwai, Kotaro, Takaya, Daisuke, Watanabe, Chiduru, Watanabe, Akira, Kawashima, Yusuke, Fukuzawa, Kaori, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Uemura, Nozomi, Kasai, Shinji, Kanuka, Hirotaka, Nishimura, Takashi, Watanabe, Kodai, Inoue, Hideshi, Fujikawa, Yuuta, Honma, Teruki, Hirokawa, Takatsugu, Senda, Toshiya, Niwa, Ryusuke

“…Mosquito control is a crucial global issue for protecting the human community from mosquito-borne diseases. There is an urgent need for the development of…”
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Synthesis of both enantiomers of 1,2,3,4-tetrahydroisoquinoline derivative IPPAM-1 and enantio-dependency of its positive allosteric modulation of prostacyclin receptor by Yamamoto, Kohki, Suzuki, Toshifumi, Imamura, Riyo, Nagano, Tetsuo, Okabe, Takayoshi, Miyachi, Hiroyuki

“…[Display omitted] We present a practical synthesis of both enantiomers of 1,2,3,4-tetrahydroisoquinoline derivative IPPAM-1 (1), which is a positive allosteric…”
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Development of p62-Keap1 protein–protein interaction inhibitors as doxorubicin-sensitizers against non-small cell lung cancer by Yasuda, Daisuke, Yoshida, Ippei, Imamura, Riyo, Katagishi, Daiki, Takahashi, Kyoko, Kojima, Hirotatsu, Okabe, Takayoshi, Ichimura, Yoshinobu, Komatsu, Masaaki, Mashino, Tadahiko, Ohe, Tomoyuki

“…Aberrant hyperactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) has been reported in non-small cell lung cancer through overexpression of the…”
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Inexpensive High-Throughput Screening of Kinase Inhibitors Using One-Step Enzyme-Coupled Fluorescence Assay for ADP Detection by Imamura, Riyo Maruki, Kumagai, Kazuo, Nakano, Hirofumi, Okabe, Takayoshi, Nagano, Tetsuo, Kojima, Hirotatsu

“…Protein kinases are attractive targets for both biological research and drug development. Several assay kits, especially for the detection of adenosine…”
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Identification of novel compounds that inhibit SnRK2 kinase activity by high-throughput screening by Matsuoka, Shoko, Sato, Karin, Maruki-Imamura, Riyo, Noutoshi, Yoshiteru, Okabe, Takayoshi, Kojima, Hirotatsu, Umezawa, Taishi

“…Abscisic acid (ABA) is a major phytohormone that regulates abiotic stress responses and development. SNF1-rerated protein kinase 2 (SnRK2) is a key regulator…”
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Structural development of 1,2,3,4-tetrahydroisoquinoline-type positive allosteric modulators of prostacyclin receptor (IPPAMs) to improve metabolic stability, and investigation of metabolic fate by Miyachi, Hiroyuki, Suzuki, Toshifumi, Imamura, Riyo, Nagano, Tetsuo, Okabe, Takayoshi

“…[Display omitted] We synthesized a series of 1,2,3,4-tetrahydroisoquinoline-type positive allosteric modulators of prostacyclin receptor (IPPAMs), aiming to…”
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Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity by Yasuda, Daisuke, Nakajima, Mao, Yuasa, Akihiro, Obata, Rika, Takahashi, Kyoko, Ohe, Tomoyuki, Ichimura, Yoshinobu, Komatsu, Masaaki, Yamamoto, Masayuki, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Mashino, Tadahiko

“…[Display omitted] The Keap1-Nrf2 system is involved not only in biological defense but also in malignancy progression and chemoresistance. The…”
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Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor by Yasuda, Daisuke, Yuasa, Akihiro, Obata, Rika, Nakajima, Mao, Takahashi, Kyoko, Ohe, Tomoyuki, Ichimura, Yoshinobu, Komatsu, Masaaki, Yamamoto, Masayuki, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Mashino, Tadahiko

“…[Display omitted] The Keap1-Nrf2 system is an attractive target for drug discovery regarding various unmet medical needs. Only covalent inhibitors for…”
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Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin by Hitsumoto, Tatsuro, Tsukamoto, Osamu, Matsuoka, Ken, Li, Junjun, Liu, Li, Kuramoto, Yuki, Higo, Shuichiro, Ogawa, Shou, Fujino, Noboru, Yoshida, Shohei, Kioka, Hidetaka, Kato, Hisakazu, Hakui, Hideyuki, Saito, Yuki, Okamoto, Chisato, Inoue, Hijiri, Hyejin, Jo, Ueda, Kyoko, Segawa, Takatsugu, Nishimura, Shunsuke, Asano, Yoshihiro, Asanuma, Hiroshi, Tani, Akiyoshi, Imamura, Riyo, Komagawa, Shinsuke, Kanai, Toshio, Takamura, Masayuki, Sakata, Yasushi, Kitakaze, Masafumi, Haruta, Jun-ichi, Takashima, Seiji

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Application of Acoustic Ejection MS System to High-Throughput Screening for SARS-CoV-2 3CL Protease Inhibitors by Hasegawa, Tsukasa, Imamura, Riyo M., Suzuki, Tateki, Hashiguchi, Takao, Nomura, Takao, Otsuguro, Satoko, Maenaka, Katsumi, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko, Okabe, Takayoshi, Nagano, Tetsuo, Kojima, Hirotatsu

“…Mass spectrometry is a powerful methodology for chemical screening to directly quantify substrates and products of enzymes, but its low throughput has been an…”
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Structure–activity relationship analysis of mosquito glutathione S -transferase Noppera-bo and its inhibitors for insecticide development by Inaba, Kazue, Koiwai, Kotaro, Ebihara, Kana, Yoshino, Ryunosuke, Hirokawa, Takatsugu, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Inoue, Hideshi, Fujikawa, Yuuta, Sakuma, Chisako, Kanuka, Hirotaka, Yumoto, Fumiaki, Senda, Toshiya, Niwa, Ryusuke

“…Abstract only…”
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153 - Development of Novel Inhibitors for Keap1-Nrf2 and Keap1-P62 Protein-Protein Interaction by Yasuda, Daisuke, Yuasa, Akihiro, Nakajima, Mao, Yoshida, Taketo, Obata, Rika, Takahashi, Kyoko, Ohe, Tomoyuki, Ichimura, Yoshinobu, Komatsu, Masaaki, Yamamoto, Masayuki, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Mashino, Tadahiko

“…Nrf2-Keap1 system is a biological defense mechanism in response to various stressors. An inhibitor for Keap1-Nrf2 interaction to activate Nrf2 is expected as a…”
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Development of Novel Inhibitors for Keap1-Nrf2 and Keap1-P62 Protein-Protein Interaction by Yasuda, Daisuke, Yuasa, Akihiro, Nakajima, Mao, Yoshida, Taketo, Obata, Rika, Takahashi, Kyoko, Ohe, Tomoyuki, Ichimura, Yoshinobu, Komatsu, Masaaki, Yamamoto, Masayuki, Imamura, Riyo, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Mashino, Tadahiko

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Development of a potent and selective FLT3 kinase inhibitor by systematic expansion of a non-selective fragment-screening hit by Nakano, Hirofumi, Hasegawa, Tsukasa, Imamura, Riyo, Saito, Nae, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo

“…[Display omitted] A non-selective inhibitor (1) of FMS-like tyrosine kinase-3 (FLT3) was identified by fragment screening and systematically modified to afford…”
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