Search Results - "Imamura, Emiko"

Defining end-of-life care from perspectives of nursing ethics by Izumi, Shigeko (Seiko), Nagae, Hiroko, Sakurai, Chihoko, Imamura, Emiko

“…Despite increasing interests and urgent needs for quality end-of-life care, there is no exact definition of what is the interval referred to as end of life or…”
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Generation and characterization of a potent fully human monoclonal antibody against the interleukin-23 receptor by Sasaki-Iwaoka, Haruna, Ohori, Makoto, Imasato, Akira, Taguchi, Katsunari, Minoura, Kyoko, Saito, Tetsu, Kushima, Kiyoshi, Imamura, Emiko, Kubo, Satoshi, Furukawa, Shigetada, Morokata, Tatsuaki

“…Interleukin (IL)-12 and IL-23 share a common subunit (p40) and function in T-helper (Th) 1 and Th17 immunity, respectively. Anti-IL-12/23p40 and specific…”
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Discovery of highly potent and selective biphenylacylsulfonamide-based β3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the β2-adrenergic receptor: Part 6 by HATTORI, Kouji, ORITA, Masaya, MATSUI, Shigeo, IMAMURA, Emiko, UESHIMA, Koji, YAMAMOTO, Takao, YAMAMOTO, Nobuhiro, ISHIKAWA, Hirofumi, NAKANO, Keiko, UNAMI, Naoko, HAMADA, Kaori, MATSUMURA, Yasuhiro, TODA, Susumu, TAKAMURA, Fujiko, IMANISHI, Masashi, ITOU, Shinji, NAKAJIMA, Yutaka, TANABE, Daisuke, WASHIZUKA, Kenichi, ARAKI, Takanobu, SAKURAI, Minoru

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Discovery of Highly Potent and Selective Biphenylacylsulfonamide-Based β3-Adrenergic Receptor Agonists and Evaluation of Physical Properties as Potential Overactive Bladder Therapies: Part 5 by Hattori, Kouji, Toda, Susumu, Imanishi, Masashi, Itou, Shinji, Nakajima, Yutaka, Washizuka, Kenichi, Araki, Takanobu, Hamashima, Hitoshi, Tomishima, Yasuyo, Sakurai, Minoru, Matsui, Shigeo, Imamura, Emiko, Ueshima, Koji, Yamamoto, Takao, Yamamoto, Nobuhiro, Ishikawa, Hirofumi, Nakano, Keiko, Unami, Naoko, Hamada, Kaori, Matsumura, Yasuhiro, Takamura, Fujiko

“…As an extension of research conducted on β3-adrenergic receptor agonists as potential drugs for treating overactive bladder (OAB), novel series containing an…”
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Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human β3-adrenergic receptor agonists: Part IV by NAKAJIMA, Yutaka, IMANISHI, Masashi, YAMAMOTO, Takao, YAMAMOTO, Nobuhiro, ISHIKAWA, Hirofumi, NAKANO, Keiko, UNAMI, Naoko, HAMADA, Kaori, HATTORI, Kouji, ITOU, Shinji, HAMASHIMA, Hitoshi, TOMISHIMA, Yasuyo, WASHIZUKA, Kenichi, SAKURAI, Minoru, MATSUI, Shigeo, IMAMURA, Emiko, UESHIMA, Koji

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In vitro pharmacological effects of peficitinib on lymphocyte activation: a potential treatment for systemic sclerosis with JAK inhibitors by Kitanaga, Yukihiro, Imamura, Emiko, Nakahara, Yutaka, Fukahori, Hidehiko, Fujii, Yasutomo, Kubo, Satoshi, Nakayamada, Shingo, Tanaka, Yoshiya

“…Abstract Objectives Peficitinib, a novel Janus kinase (JAK) inhibitor, demonstrated promising results in treating RA in phase 3 clinical trials. This in vitro…”
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Anti-IL-23 receptor monoclonal antibody prevents CD4+ T cell-mediated colitis in association with decreased systemic Th1 and Th17 responses by Imamura, Emiko, Taguchi, Katsunari, Sasaki-Iwaoka, Haruna, Kubo, Satoshi, Furukawa, Shigetada, Morokata, Tatsuaki

“…Experimental colitis studies, including T cell-mediated colitis, indicate that IL-23 rather than IL-12 orchestrates intestinal inflammation in inflammatory…”
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ASP7266, a Novel Antibody against Human Thymic Stromal Lymphopoietin Receptor for the Treatment of Allergic Diseases by Numazaki, Mako, Abe, Masaki, Hanaoka, Kaori, Imamura, Emiko, Maeda, Masashi, Kimura, Akihiko, Miyanohara, Jun, Saito, Tetsu, Arai, Kazunori, Suzuki, Hiroshi, Saita, Yuji

“…Thymic stromal lymphopoietin (TSLP), positioned at the top of the inflammatory cascade, is a key regulator that enhances allergic inflammatory responses by…”
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Design, synthesis, and pharmacological evaluation of N-(3-carbamoyl-1H-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as interleukin-1 receptor-associated kinase 4 inhibitors with reduced potential for cytochrome P450 1A2 induction by Inami, Hiroshi, Mizutani, Tsuyoshi, Watanabe, Junko, Hayashida, Hisashi, Ito, Tomonori, Terasawa, Takeshi, Kontani, Toru, Yamagishi, Hiroaki, Usuda, Hiroyuki, Aoyama, Naohiro, Imamura, Emiko, Ishikawa, Takeshi

“…[Display omitted] Interleukin-1 receptor-associated kinase 4 (IRAK4) is a critical molecule in Toll-like receptor/interleukin-1 receptor signaling and an…”
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AS2762900-00, a potent anti-human IL-23 receptor monoclonal antibody, prevents epidermal hyperplasia in a psoriatic human skin xenograft model by Sasaki-Iwaoka, Haruna, Taguchi, Katsunari, Okada, Yohei, Imamura, Emiko, Kubo, Satoshi, Furukawa, Shigetada, Morokata, Tatsuaki

“…Interleukin (IL)-23 is thought to be critical in the pathogenesis of psoriasis, and anti-IL-23 monoclonal antibodies (mAbs) have been approved for the…”
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ASP7266, a novel antibody against human TSLPR, in the treatment of allergic disease by Numazaki, Mako, Hanaoka, Kaori, Imamura, Emiko, Maeda, Masashi, Arai, Kazunori, Saito, Tetsu, Takamura, Fujiko, Suzuki, Hiroshi, Kubo, Satoshi, Furukawa, Shigetada

“…The inhibitory effect of ASP7266 on TSLP-induced chemokine (C-C motif) ligand (CCL) 17 mRNA expression was examined in human and monkey peripheral white blood…”
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Discovery of a Novel Series of Biphenyl Benzoic Acid Derivatives as Potent and Selective Human β3-Adrenergic Receptor Agonists with Good Oral Bioavailability. Part I by Imanishi, Masashi, Tomishima, Yasuyo, Itou, Shinji, Hamashima, Hitoshi, Nakajima, Yutaka, Washizuka, Kenichi, Sakurai, Minoru, Matsui, Shigeo, Imamura, Emiko, Ueshima, Koji, Yamamoto, Takao, Yamamoto, Nobuhiro, Ishikawa, Hirofumi, Nakano, Keiko, Unami, Naoko, Hamada, Kaori, Matsumura, Yasuhiro, Takamura, Fujiko, Hattori, Kouji

“…A novel class of biphenyl analogues containing a benzoic acid moiety based on lead compound 8i have been identified as potent and selective human β3 adrenergic…”
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Sixty percent of patients with rheumatoid arthritis in Japan have used dietary supplements or health foods by Ikuyama, Shoichiro, Imamura-Takase, Emiko, Tokunaga, Shoji, Oribe, Motohiro, Nishimura, Junji

“…Abstract We conducted a survey on the use of dietary supplements and health foods (DS/HF) in definite rheumatoid arthritis (RA) patients treated by RA…”
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Discovery of a Novel Series of Benzoic Acid Derivatives as Potent and Selective Human β3 Adrenergic Receptor Agonists with Good Oral Bioavailability. 3. Phenylethanolaminotetraline (PEAT) Skeleton Containing Biphenyl or Biphenyl Ether Moiety by Imanishi, Masashi, Nakajima, Yutaka, Tomishima, Yasuyo, Hamashima, Hitoshi, Washizuka, Kenichi, Sakurai, Minoru, Matsui, Shigeo, Imamura, Emiko, Ueshima, Koji, Yamamoto, Takao, Yamamoto, Nobuhiro, Ishikawa, Hirofumi, Nakano, Keiko, Unami, Naoko, Hamada, Kaori, Matsumura, Yasuhiro, Takamura, Fujiko, Hattori, Kouji

“…We designed a series of benzoic acid derivatives containing the biphenyl ether or biphenyl template on the RHS and a phenylethanolaminotetraline (PEAT)…”
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Discovery of a Novel Series of Biphenyl Benzoic Acid Derivatives as Highly Potent and Selective Human β3 Adrenergic Receptor Agonists with Good Oral Bioavailability. Part II by Imanishi, Masashi, Itou, Shinji, Washizuka, Kenichi, Hamashima, Hitoshi, Nakajima, Yutaka, Araki, Takanobu, Tomishima, Yasuyo, Sakurai, Minoru, Matsui, Shigeo, Imamura, Emiko, Ueshima, Koji, Yamamoto, Takao, Yamamoto, Nobuhiro, Ishikawa, Hirofumi, Nakano, Keiko, Unami, Naoko, Hamada, Kaori, Matsumura, Yasuhiro, Takamura, Fujiko, Hattori, Kouji

“…The left-hand side (LHS) and central part of our first generation biphenyl (FGB) series was modified to improve in vitro and in vivo β3-AR potency without loss…”
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Older Japanese adults' religiosity: Relationship with age; gender; physical, mental, and cognitive health; subjective feelings about health; social support/integration; and health promotion behaviors by Imamura, Emiko

“…The purpose of this study was to identify predictors of older Japanese adults' health promotion behaviors by examining relationships between their religiosity…”
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Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV by Nakajima, Yutaka, Imanishi, Masashi, Itou, Shinji, Hamashima, Hitoshi, Tomishima, Yasuyo, Washizuka, Kenichi, Sakurai, Minoru, Matsui, Shigeo, Imamura, Emiko, Ueshima, Koji, Yamamoto, Takao, Yamamoto, Nobuhiro, Ishikawa, Hirofumi, Nakano, Keiko, Unami, Naoko, Hamada, Kaori, Hattori, Kouji

“…Identification and SAR study of novel series of beta(3)-AR agonists with benzoic acid are described. Conversion of ether linkage position of phenoxybenzoic…”
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Amy's Chat Room: Health promotion programmes for community dwelling elderly adults by Imamura, Emiko

“…Clinical nurse specialists in community health nursing promote wellness and quality of life in elderly adults who live within the community. Major health…”
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Discovery of a Novel Series of Benzoic Acid Derivatives as Potent and Selective Human β 3 Adrenergic Receptor Agonists with Good Oral Bioavailability. 3. Phenylethanolaminotetraline (PEAT) Skeleton Containing Biphenyl or Biphenyl Ether Moiety by Imanishi, Masashi, Nakajima, Yutaka, Tomishima, Yasuyo, Hamashima, Hitoshi, Washizuka, Kenichi, Sakurai, Minoru, Matsui, Shigeo, Imamura, Emiko, Ueshima, Koji, Yamamoto, Takao, Yamamoto, Nobuhiro, Ishikawa, Hirofumi, Nakano, Keiko, Unami, Naoko, Hamada, Kaori, Matsumura, Yasuhiro, Takamura, Fujiko, Hattori, Kouji

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Discovery of a novel, potent and selective human β 3-adrenergic receptor agonist by Nakajima, Yutaka, Hamashima, Hitoshi, Washizuka, Ken-Ichi, Tomishima, Yasuyo, Ohtake, Hiroaki, Imamura, Emiko, Miura, Toshiko, Kayakiri, Hiroshi, Kato, Masayuki

“…Design and structure–activity relationships of a novel β 3-adrenergic receptor agonist are described. The discovery of a novel, potent and selective β…”
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