Search Results - "Imamoto, Akira"

Cell shape‐based chemical screening reveals an epigenetic network mediated by focal adhesions by Kanazawa, Tomomi, Michida, Hiroki, Uchino, Yuki, Ishihara, Akari, Zhang, Suxiang, Tabata, Sho, Suzuki, Yutaka, Imamoto, Akira, Okada, Mariko

“…Adapter proteins CRK and CRKL participate in a variety of signaling pathways, including cell adhesion, and fate regulation of mammalian cells. However, the…”
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Dose-Dependent Interaction of Tbx1 and Crkl and Locally Aberrant RA Signaling in a Model of del22q11 Syndrome by Guris, Deborah L., Duester, Gregg, Papaioannou, Virginia E., Imamoto, Akira

“…22q11 deletion ( del22q11) syndrome is characterized genetically by heterozygous deletions within chromosome 22q11 and clinically by a constellation of…”
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Activation of a Dab1/CrkL/C3G/Rap1 Pathway in Reelin-Stimulated Neurons by Ballif, Bryan A, Arnaud, Lionel, Arthur, William T, Guris, Deborah, Imamoto, Akira, Cooper, Jonathan A

“…During brain development, many neurons migrate long distances before settling and differentiating. These migrations are coordinated to ensure normal…”
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A pre-metazoan origin of the CRK gene family and co-opted signaling network by Shigeno-Nakazawa, Yoko, Kasai, Takuma, Ki, Sewon, Kostyanovskaya, Elina, Pawlak, Jana, Yamagishi, Junya, Okimoto, Noriaki, Taiji, Makoto, Okada, Mariko, Westbrook, Jody, Satta, Yoko, Kigawa, Takanori, Imamoto, Akira

“…CRK and CRKL adapter proteins play essential roles in development and cancer through their SRC homology 2 and 3 (SH2 and SH3) domains. To gain insight into the…”
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The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling by Hagel, Margit, George, Elizabeth L., Kim, Ann, Tamimi, Rulla, Opitz, Sarah L., Turner, Christopher E., Imamoto, Akira, Thomas, Sheila M.

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Crkl Deficiency Disrupts Fgf8 Signaling in a Mouse Model of 22q11 Deletion Syndromes by Moon, Anne M., Guris, Deborah L., Seo, Ji-heui, Li, Leiming, Hammond, Jennetta, Talbot, Amy, Imamoto, Akira

“…Deletions on chromosome 22q11.21 disrupt pharyngeal and cardiac development and cause DiGeorge and related human syndromes. CRKL ( CRK-Like) lies within…”
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Structural and Functional Basis of a Role for CRKL in a Fibroblast Growth Factor 8-Induced Feed-Forward Loop by Seo, Ji-Heui, Suenaga, Atsushi, Hatakeyama, Mariko, Taiji, Makoto, Imamoto, Akira

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Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome by Imamoto, Akira, Guris, Deborah L, Fantes, Judith, Tara, David, Druker, Brian J

“…Heterozygous deletions within human chromosome 22q11 are the genetic basis of DiGeorge/velocardiofacial syndrome (DGS/VCFS), the most common deletion syndrome…”
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Disruption of Overlapping Transcripts in the ROSA β geo 26 Gene Trap Strain Leads to Widespread Expression of β -Galactosidase in Mouse Embryos and Hematopoietic Cells by Zambrowicz, Brian P., Imamoto, Akira, Fiering, Steve, Herzenberg, Leonard A., Kerr, William G., Soriano, Philippe

“…The ROSAβ geo26 (ROSA26) mouse strain was produced by random retroviral gene trapping in embryonic stem cells. Staining of ROSA26 tissues and…”
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Focal Adhesions Require Catalytic Activity of Src Family Kinases To Mediate Integrin-Matrix Adhesion by Li, Leiming, Okura, Masaya, Imamoto, Akira

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Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration by Shemon, Anne N, Eves, Eva M, Clark, Matthew C, Heil, Gary, Granovsky, Alexey, Zeng, Lingchun, Imamoto, Akira, Koide, Shohei, Rosner, Marsha Rich

“…Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling…”
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Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice by Imamoto, A, Soriano, P

“…All Src family non-receptor tyrosine kinases are negatively regulated by phosphorylation at a carboxy-terminal tyrosine. To analyze the significance of this…”
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Translocation of CrkL to Focal Adhesions Mediates Integrin-Induced Migration Downstream of Src Family Kinases by Li, Leiming, Guris, Deborah L., Okura, Masaya, Imamoto, Akira

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A Specific Need for CRKL in p210BCR-ABL―Induced Transformation of Mouse Hematopoietic Progenitors by SEO, Ji-Heui, WOOD, Lisa J, AGARWAL, Anupriya, O'HARE, Thomas, ELSEA, Collin R, GRISWOLD, Lan J, DEININGER, Michael W. N, IMAMOTO, Akira, DRUKER, Brian J

“…CRKL (CRK-like) is an adapter protein predominantly phosphorylated in cells that express the tyrosine kinase p210(BCR-ABL), the fusion product of a (9;22)…”
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COOH-terminal src kinase-mediated c-jun phosphorylation promotes c-jun degradation and inhibits cell transformation by FENG ZHU, BU YOUNG CHOI, MA, Wei-Ya, ZHONGLIANG ZHAO, YIGUO ZHANG, YONG YEON CHO, HONG SEOK CHOI, IMAMOTO, Akira, BODE, Ann M, ZIGANG DONG

“…The oncoprotein c-Jun is a component of the activator protein-1 transcription factor complex, which is involved in cellular proliferation, transformation, and…”
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Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization by Duan, Li-Juan, Imamoto, Akira, Fong, Guo-Hua

“…Here we report that C-terminal Src kinase (Csk), a tyrosine kinase that negatively regulates the activity of Src and related kinases, is important for vascular…”
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Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development by Haller, Meade, Mo, Qianxing, Imamoto, Akira, Lamb, Dolores J.

“…The spectrum of congenital anomalies affecting either the upper tract (kidneys and ureters) or lower tract (reproductive organs) of the genitourinary (GU)…”
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Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression by Dey, A, She, H, Kim, L, Boruch, A, Guris, D L, Carlberg, K, Sebti, S M, Woodley, D T, Imamoto, A, Li, W

“…Colony-stimulating factor-1 (CSF-1) induces expression of immediate early gene, such as c-myc and c-fos and delayed early genes such as D-type cyclins (D1 and…”
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Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target by Zeng, Lingchun, Imamoto, Akira, Rosner, Marsha Rich

“…Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein (PEBP) family that is expressed in both prokaryotic and…”
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Genetic Drivers of Kidney Defects in the DiGeorge Syndrome by Lopez-Rivera, Esther, Liu, Yangfan P, Verbitsky, Miguel, Anderson, Blair R, Capone, Valentina P, Otto, Edgar A, Yan, Zhonghai, Mitrotti, Adele, Martino, Jeremiah, Steers, Nicholas J, Fasel, David A, Vukojevic, Katarina, Deng, Rong, Racedo, Silvia E, Liu, Qingxue, Werth, Max, Westland, Rik, Vivante, Asaf, Makar, Gabriel S, Bodria, Monica, Sampson, Matthew G, Gillies, Christopher E, Vega-Warner, Virginia, Maiorana, Mariarosa, Petrey, Donald S, Honig, Barry, Lozanovski, Vladimir J, Salomon, Rémi, Heidet, Laurence, Carpentier, Wassila, Gaillard, Dominique, Carrea, Alba, Gesualdo, Loreto, Cusi, Daniele, Izzi, Claudia, Scolari, Francesco, van Wijk, Joanna A.E, Arapovic, Adela, Saraga-Babic, Mirna, Saraga, Marijan, Kunac, Nenad, Samii, Ali, McDonald-McGinn, Donna M, Crowley, Terrence B, Zackai, Elaine H, Drozdz, Dorota, Miklaszewska, Monika, Tkaczyk, Marcin, Sikora, Przemyslaw, Szczepanska, Maria, Mizerska-Wasiak, Malgorzata, Krzemien, Grazyna, Szmigielska, Agnieszka, Zaniew, Marcin, Darlow, John M, Puri, Prem, Barton, David, Casolari, Emilio, Furth, Susan L, Warady, Bradley A, Gucev, Zoran, Hakonarson, Hakon, Flogelova, Hana, Tasic, Velibor, Latos-Bielenska, Anna, Materna-Kiryluk, Anna, Allegri, Landino, Wong, Craig S, Drummond, Iain A, D’Agati, Vivette, Imamoto, Akira, Barasch, Jonathan M, Hildebrandt, Friedhelm, Kiryluk, Krzysztof, Lifton, Richard P, Morrow, Bernice E, Jeanpierre, Cecile, Papaioannou, Virginia E, Ghiggeri, Gian Marco, Gharavi, Ali G, Katsanis, Nicholas, Sanna-Cherchi, Simone

“…A third of patients with the DiGeorge syndrome have congenital kidney and urinary tract anomalies. This study provides evidence that haploinsufficiency of CRKL…”
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