Search Results - "Imajo, Masamichi"

Hemagglutinating Virus of Japan Envelope (HVJ-E)-Guided Gene Transfer to the Intestinal Epithelium by Imajo, Masamichi

“…The rapidly self-renewing epithelium of the small intestine represents an exquisite model for the stem cell-driven tissue renewal and tumorigenesis. Intestinal…”
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Analysis of Retinoic Acid Receptor Signaling in Colorectal Cancer by Imajo, Masamichi

“…Retinoic acid receptor (RAR) signaling plays an important role in embryonic development and homeostasis of many tissues. At the cellular level, activation of…”
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Dual role of YAP and TAZ in renewal of the intestinal epithelium by Imajo, Masamichi, Ebisuya, Miki, Nishida, Eisuke

“…The rapidly self-renewing intestinal epithelium represents an exquisite model for stem cell biology. So far, genetic studies in mice have uncovered crucial…”
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HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer by Ordóñez-Morán, Paloma, Dafflon, Caroline, Imajo, Masamichi, Nishida, Eisuke, Huelsken, Joerg

“…Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation…”
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In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines by Mizuno, Rei, Kamioka, Yuji, Kabashima, Kenji, Imajo, Masamichi, Sumiyama, Kenta, Nakasho, Eiji, Ito, Takeshi, Hamazaki, Yoko, Okuchi, Yoshihisa, Sakai, Yoshiharu, Kiyokawa, Etsuko, Matsuda, Michiyuki

“…Many chemical mediators regulate neutrophil recruitment to inflammatory sites. Although the actions of each chemical mediator have been demonstrated with…”
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Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine by Muta, Yu, Fujita, Yoshihisa, Sumiyama, Kenta, Sakurai, Atsuro, Taketo, M. Mark, Chiba, Tsutomu, Seno, Hiroshi, Aoki, Kazuhiro, Matsuda, Michiyuki, Imajo, Masamichi

“…Acting downstream of many growth factors, extracellular signal-regulated kinase (ERK) plays a pivotal role in regulating cell proliferation and tumorigenesis,…”
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Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction by Tanikawa, Satoshi, Ebisu, Yuki, Sedlačík, Tomáš, Semba, Shingo, Nonoyama, Takayuki, Kurokawa, Takayuki, Hirota, Akira, Takahashi, Taiga, Yamaguchi, Kazushi, Imajo, Masamichi, Kato, Hinako, Nishimura, Takuya, Tanei, Zen-ichi, Tsuda, Masumi, Nemoto, Tomomi, Gong, Jian Ping, Tanaka, Shinya

“…Neural regeneration is extremely difficult to achieve. In traumatic brain injuries, the loss of brain parenchyma volume hinders neural regeneration. In this…”
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A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs by Konagaya, Yumi, Terai, Kenta, Hirao, Yusuke, Takakura, Kanako, Imajo, Masamichi, Kamioka, Yuji, Sasaoka, Norio, Kakizuka, Akira, Sumiyama, Kenta, Asano, Tomoichiro, Matsuda, Michiyuki

“…AMP-activated protein kinase (AMPK), a master regulator of cellular metabolism, is a potential target for type 2 diabetes. Although extensive in vitro studies…”
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Regulatory mechanisms and functions of MAP kinase signaling pathways by Imajo, Masamichi, Tsuchiya, Yoshiki, Nishida, Eisuke

“…Mitogen‐activated protein kinase (MAPK) pathways play central roles in controlling diverse cellular functions. They are finely regulated by several mechanisms,…”
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ERK MAP Kinase Signaling Regulates RAR Signaling to Confer Retinoid Resistance on Breast Cancer Cells by Hirota, Akira, Clément, Jean-Emmanuel, Tanikawa, Satoshi, Nonoyama, Takayuki, Komatsuzaki, Tamiki, Gong, Jian Ping, Tanaka, Shinya, Imajo, Masamichi

“…Retinoic acid (RA) and its synthetic derivatives, retinoids, have been established as promising anticancer agents based on their ability to regulate cell…”
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Human Tribbles homolog 1 functions as a negative regulator of retinoic acid receptor by Imajo, Masamichi, Nishida, Eisuke

“…Tribbles encode an evolutionarily conserved protein family that regulates cell proliferation, motility, metabolism and oncogenic transformation. Emerging…”
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Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis by Okuchi, Yoshihisa, Imajo, Masamichi, Mizuno, Rei, Kamioka, Yuji, Miyoshi, Hiroyuki, Taketo, Makoto Mark, Nagayama, Satoshi, Sakai, Yoshiharu, Matsuda, Michiyuki

“…Aging-associated alterations of cellular functions have been implicated in various disorders including cancers. Due to difficulties in identifying aging cells…”
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Dynamic ERK signaling regulation in intestinal tumorigenesis by Muta, Yu, Matsuda, Michiyuki, Imajo, Masamichi

“…Extracellular signal-regulated kinase (ERK) plays a critical role in tissue homeostasis and tumorigenesis. By utilizing live imaging approaches, we recently…”
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A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling by Imajo, Masamichi, Miyatake, Koichi, Iimura, Akira, Miyamoto, Atsumu, Nishida, Eisuke

“…The Hippo signalling pathway has emerged as a key regulator of organ size, tissue homeostasis, and patterning. Recent studies have shown that two effectors in…”
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Biomaterials for intestinal organoid technology and personalized disease modeling by Hirota, Akira, AlMusawi, Shaikha, Nateri, Abdolrahman S., Ordóñez-Morán, Paloma, Imajo, Masamichi

“…Recent advances in intestinal organoid technologies have paved the way for in vitro recapitulation of the homeostatic renewal of adult tissues, tissue or organ…”
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Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes by Kon, Shunsuke, Ishibashi, Kojiro, Katoh, Hiroto, Kitamoto, Sho, Shirai, Takanobu, Tanaka, Shinya, Kajita, Mihoko, Ishikawa, Susumu, Yamauchi, Hajime, Yako, Yuta, Kamasaki, Tomoko, Matsumoto, Tomohiro, Watanabe, Hirotaka, Egami, Riku, Sasaki, Ayana, Nishikawa, Atsuko, Kameda, Ikumi, Maruyama, Takeshi, Narumi, Rika, Morita, Tomoko, Sasaki, Yoshiteru, Enoki, Ryosuke, Honma, Sato, Imamura, Hiromi, Oshima, Masanobu, Soga, Tomoyoshi, Miyazaki, Jun-ichi, Duchen, Michael R., Nam, Jin-Min, Onodera, Yasuhito, Yoshioka, Shingo, Kikuta, Junichi, Ishii, Masaru, Imajo, Masamichi, Nishida, Eisuke, Fujioka, Yoichiro, Ohba, Yusuke, Sato, Toshiro, Fujita, Yasuyuki

“…Recent studies have revealed that newly emerging transformed cells are often apically extruded from epithelial tissues. During this process, normal epithelial…”
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Divergent Dynamics and Functions of ERK MAP Kinase Signaling in Development, Homeostasis and Cancer: Lessons from Fluorescent Bioimaging by Muta, Yu, Matsuda, Michiyuki, Imajo, Masamichi

“…The extracellular signal-regulated kinase (ERK) signaling pathway regulates a variety of biological processes including cell proliferation, survival, and…”
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Abstract A50: Analysis of molecular mechanisms underlying colon cancer development by 3D culture system by Sakurai, Atsuro, Imajo, Masamichi, Matsuda, Michiyuki

“…Abstract Intestinal stem cells produce all types of intestinal epithelial cells including absorptive enterocytes and secretory cells to maintain the…”
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Antagonistic Interactions between Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Retinoic Acid Receptor Signaling in Colorectal Cancer Cells by Imajo, Masamichi, Kondoh, Kunio, Yamamoto, Takuya, Nakayama, Kei, Nakajima-Koyama, May, Nishida, Eisuke

“…Deregulated activation of RAS/extracellular signal-regulated kinase (ERK) signaling and defects in retinoic acid receptor (RAR) signaling are both implicated…”
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A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling: Hippo signalling regulates β-catenin localization by Imajo, Masamichi, Miyatake, Koichi, Iimura, Akira, Miyamoto, Atsumu, Nishida, Eisuke

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