Search Results - "Imai, Yuuki"

Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions by Saeki, Noritaka, Imai, Yuuki

“…Macrophages adapt to microenvironments, and change metabolic status and functions to regulate inflammation and/or maintain homeostasis. In joint cavities,…”
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Cell-specific functions of androgen receptor in skeletal muscles by Sakai, Hiroshi, Imai, Yuuki

“…Androgens play a vital role not only in promoting the development of male sexual characteristics but also in exerting diverse physiological effects, including…”
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Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue by Saeki, Noritaka, Imai, Yuuki

“…Rheumatoid arthritis is an autoimmune disease that leads to chronic inflammation of joints. Synovial macrophages and synovial fibroblasts have central roles in…”
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Identification of Novel Transcription Factors in Osteoclast Differentiation Using Genome‐wide Analysis of Open Chromatin Determined by DNase‐seq by Inoue, Kazuki, Imai, Yuuki

“…ABSTRACT Clarification of the mechanisms underlying osteoclast differentiation enables us to understand the physiology of bone metabolism as well as the…”
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Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation by Inoue, Kazuki, Imai, Yuuki

“…Osteoclast differentiation is associated with both normal bone homeostasis and pathological bone diseases such as osteoporosis. Several transcription factors…”
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Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage by Haraguchi, Ryuma, Kitazawa, Riko, Kohara, Yukihiro, Imai, Yuuki, Kitazawa, Sohei

“…Pericytes are pluripotent cells that enclose the endothelium of small blood vessels in the whole body. These cells are thought to play a limited role in…”
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Raman Spectroscopic Analysis to Detect Reduced Bone Quality after Sciatic Neurectomy in Mice by Ishimaru, Yasumitsu, Oshima, Yusuke, Imai, Yuuki, Iimura, Tadahiro, Takanezawa, Sota, Hino, Kazunori, Miura, Hiromasa

“…Bone mineral density (BMD) is a commonly used diagnostic indicator for bone fracture risk in osteoporosis. Along with low BMD, bone fragility accounts for…”
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Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss by Kohara, Yukihiro, Haraguchi, Ryuma, Kitazawa, Riko, Imai, Yuuki, Kitazawa, Sohei

“…The functional role of the Hedgehog (Hh)-signaling pathway has been widely investigated in bone physiology/development. Previous studies have, however, focused…”
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Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate by Haraguchi, Ryuma, Kitazawa, Riko, Kohara, Yukihiro, Ikedo, Aoi, Imai, Yuuki, Kitazawa, Sohei

“…The longitudinal growth of long bone, regulated by an epiphyseal cartilaginous component known as the "growth plate", is generated by epiphyseal chondrocytes…”
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Ingestion of a collagen peptide containing high concentrations of prolyl-hydroxyproline and hydroxyprolyl-glycine reduces advanced glycation end products levels in the skin and subcutaneous blood vessel walls: a randomized, double-blind, placebo-controlled study by Koizumi, Seiko, Okada, Yoko, Miura, Shiroh, Imai, Yuuki, Igase, Keiji, Ohyagi, Yasumasa, Igase, Michiya

“…ABSTRACT In this randomized, double-blind, placebo-controlled study, we investigated the effects of collagen peptides (CP) containing high concentrations of…”
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The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation by Suzuki, Junpei, Yamada, Takeshi, Inoue, Kazuki, Nabe, Shogo, Kuwahara, Makoto, Takemori, Nobuaki, Takemori, Ayako, Matsuda, Seiji, Kanoh, Makoto, Imai, Yuuki, Yasukawa, Masaki, Yamashita, Masakatsu

“…While menin plays an important role in preventing T-cell dysfunction, such as senescence and exhaustion, the regulatory mechanisms remain unclear. We found…”
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GlcNAcylation of histone H2B facilitates its monoubiquitination by Fujiki, Ryoji, Hashiba, Waka, Sekine, Hiroki, Yokoyama, Atsushi, Chikanishi, Toshihiro, Ito, Saya, Imai, Yuuki, Kim, Jaehoon, He, Housheng Hansen, Igarashi, Katsuhide, Kanno, Jun, Ohtake, Fumiaki, Kitagawa, Hirochika, Roeder, Robert G., Brown, Myles, Kato, Shigeaki

“…Genome-wide analysis shows that H2B S112 O -linked to N -acetylglucosamine is frequently located near transcribed genes, suggesting that histone GlcNAcylation…”
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Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation by Yamanaka, Satoshi, Furihata, Hirotake, Yanagihara, Yuta, Taya, Akihito, Nagasaka, Takato, Usui, Mai, Nagaoka, Koya, Shoya, Yuki, Nishino, Kohei, Yoshida, Shuhei, Kosako, Hidetaka, Tanokura, Masaru, Miyakawa, Takuya, Imai, Yuuki, Shibata, Norio, Sawasaki, Tatsuya

“…Lenalidomide, an immunomodulatory drug (IMiD), is commonly used as a first-line therapy in many haematological cancers, such as multiple myeloma (MM) and 5q…”
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Histone H3K27 demethylase, Utx, regulates osteoblast-to-osteocyte differentiation by Xia, Yuhan, Ikedo, Aoi, Lee, Ji-Won, Iimura, Tadahiro, Inoue, Kazuki, Imai, Yuuki

“…Osteocytes are master regulators of skeletal homeostasis. However, little is known about the molecular mechanism of their differentiation. Epigenetic…”
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Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner by Saeki, Noritaka, Inoue, Kazuki, Ideta-Otsuka, Maky, Watamori, Kunihiko, Mizuki, Shinichi, Takenaka, Katsuto, Igarashi, Katsuhide, Miura, Hiromasa, Takeda, Shu, Imai, Yuuki

“…Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation with aberrant epigenetic alterations, eventually leading to joint destruction…”
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sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss by Haraguchi, Ryuma, Kitazawa, Riko, Mori, Kiyoshi, Tachibana, Ryosuke, Kiyonari, Hiroshi, Imai, Yuuki, Abe, Takaya, Kitazawa, Sohei

“…sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts. Bone fragility under oxidative stress by diabetes and…”
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Deletion of Tfam in Prx1-Cre expressing limb mesenchyme results in spontaneous bone fractures by Yoshioka, Hiroki, Komura, Shingo, Kuramitsu, Norishige, Goto, Atsushi, Hasegawa, Tomoka, Amizuka, Norio, Ishimoto, Takuya, Ozasa, Ryosuke, Nakano, Takayoshi, Imai, Yuuki, Akiyama, Haruhiko

“…Introduction Osteoblasts require substantial amounts of energy to synthesize the bone matrix and coordinate skeleton mineralization. This study analyzed the…”
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Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion by Shimizu, Kouhei, Uematsu, Atsushi, Imai, Yuuki, Sawasaki, Tatsuya

“…•Pctaire1/Cdk16 promotes myogenic differentiation of C2C12 myoblasts.•Pctaire1 expression is up-regulated during myogenic differentiation.•Suppression of…”
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Effect of hormonal therapy on the otoconial changes caused by estrogen deficiency by Nakata, Takahiro, Okada, Masahiro, Nishihara, Eriko, Ikedo, Aoi, Asoh, Sawa, Takagi, Taro, Tokunaga, Naohito, Hato, Naohito, Imai, Yuuki

“…Benign paroxysmal positional vertigo (BPPV) is associated with menopause and/or osteopenia. Morphological changes in the otoconial layer have been reported…”
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Uhrf1 is indispensable for normal limb growth by regulating chondrocyte differentiation through specific gene expression by Yamashita, Michiko, Inoue, Kazuki, Saeki, Noritaka, Ideta-Otsuka, Maky, Yanagihara, Yuta, Sawada, Yuichiro, Sakakibara, Iori, Lee, Jiwon, Ichikawa, Koichi, Kamei, Yoshiaki, Iimura, Tadahiro, Igarashi, Katsuhide, Takada, Yasutsugu, Imai, Yuuki

“…Transcriptional regulation can be tightly orchestrated by epigenetic regulators. Among these, ubiquitin-like with PHD and RING finger domains 1 (Uhrf1) is…”
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