Search Results - "Imada, Keisuke"

Lysophosphatidic Acid Augments the Gene Expression and Production of Matrix Metalloproteinases-1 and -3 in Human Synovial Fibroblasts in Vitro by Mizuno, Koji, Komiya, Michika, Okuyama, Katsuki, Imada, Keisuke, Sato, Takashi

“…Rheumatoid arthritis (RA) is an inflammatory disease with joint dysfunction following cartilage degradation. The level of lysophosphatidic acid (LPA) has been…”
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Involvement of Catechols in Acteoside in the Activation of Promatrix Metalloproteinase-2 and Membrane Type-1-Matrix Metalloproteinase Expression via a Phosphatidylinositol-3-Kinase Pathway in Human Dermal Fibroblasts by Si, Nan, Kanazawa, Hajime, Okuyama, Katsuki, Imada, Keisuke, Wang, Hongjie, Yang, Jian, Zhao, Haiyu, Bian, Baolin, Ito, Akira, Sato, Takashi

“…Granulation tissue formation during skin wound healing requires the migration and proliferation of dermal fibroblasts in the wound site, where a subsequent…”
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Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor by Shibuya, Takumi, Kamiyama, Asami, Sawada, Hirotaka, Kikuchi, Kenta, Maruyama, Mayu, Sawado, Rie, Ikeda, Naoki, Asano, Kenichi, Kurotaki, Daisuke, Tamura, Tomohiko, Yoneda, Atsuko, Imada, Keisuke, Satoh, Takashi, Akira, Shizuo, Tanaka, Masato, Yotsumoto, Satoshi

“…Systemic and local inflammation associated with therapeutic intervention of primary tumor occasionally promotes metastatic recurrence in mouse and human…”
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Anti-arthritic Action Mechanisms of Natural Chondroitin Sulfate in Human Articular Chondrocytes and Synovial Fibroblasts by Imada, Keisuke, Oka, Hideki, Kawasaki, Daisuke, Miura, Naoyoshi, Sato, Takashi, Ito, Akira

“…To clarify the exact anti-arthritic action mechanisms of chondroitin sulfate (CS), we evaluated the effects of CS derived from shark cartilage (CS-SC) composed…”
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Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblasts by Sato, Takashi, Ota, Tomoko, Watanabe, Mami, Imada, Keisuke, Nomizu, Motoyoshi, Ito, Akira

“…Abstract Objective Extracellular matrix metalloproteinase inducer (EMMPRIN) is highly expressed on malignant tumor cell surface and accelerates tumor invasion…”
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Action Mechanisms of Complementary and Alternative Medicine Therapies for Rheumatoid Arthritis by Keisuke, Imada, Bian, Bao-lin, Li, Xiang-dong, Takashi, Sato, Akira, Ito

“…Rheumatoid arthritis （RA） is characterized as a chronic inflammatory disease in joints and concomitant destruction of cartilage and bone. Cartilage…”
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An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metalloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit by Imada, Keisuke, Sato, Takashi, Hashizume, Kazuyoshi, Tanimoto, Akihide, Sasaguri, Yasuyuki, Ito, Akira

“…Using a progesterone receptor antagonist, onapristone/ZK 98.299, we examined the in-vivo effects of progesterone on the function of uterine cervix during…”
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Hormonal regulation of matrix metalloproteinase 9/gelatinase B gene expression in rabbit uterine cervical fibroblasts by IMADA, K, ITO, A, SATO, T, NAMIKI, M, NAGASE, H, MORI, Y

“…Since the degradation of uterine cervical extracellular matrix is an essential process in cervical ripening and dilatation at term, we examined the effect of…”
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Suppressive effect of taurine on platelet-derived growth factor (PDGF) BB-induced c-fos and c-jun mRNA expressions through extracellular signal-regulated kinase (ERK) in mesenchymal cell lines by Terashima, M. (Shimane Medical Univ., Izumo (Japan)), Mitani, T, Hosokawa, Y, Nariai, Y, Imada, K, Kageyama, E, Tanigawa, Y

“…Platelet-derived growth factor (PDGF) plays an important role in the pathogenic course of atherosclerosis, pulmonary fibrosis, and glomerulonephritis, and…”
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Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro by Imada, Keisuke, Tsuchida, Ayana, Ogawa, Kazunori, Sofat, Nidhi, Nagase, Hideaki, Ito, Akira, Sato, Takashi

“…An inverse correlation between the morbidity of rheumatoid arthritis and daily intake of β-cryptoxanthin has been epidemiologically shown. In this study, we…”
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Inhibitory mechanism of taurine on the platelet-derived growth factor BB-mediated proliferation in aortic vascular smooth muscle cells by Imada, Keisuke, Hosokawa, Yu, Terashima, Masaharu, Mitani, Toshifumi, Tanigawa, Yoshinori, Nakano, Kazumi, Takenaga, Takaaki, Kurachi, Michio

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Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro by Imada, Keisuke, Ayana Tsuchida, Kazunori Ogawa, Nidhi Sofat, Hideaki Nagase, Akira Ito, Takashi Sato

“…An inverse correlation between the morbidity of rheumatoid arthritis and daily intake of β-cryptoxanthin has been epidemiologically shown. In this study, we…”
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A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells by Miyata, Yoshiki, Sato, Takashi, Imada, Keisuke, Dobashi, Akira, Yano, Masamichi, Ito, Akira

“…The activation of mitogen-activated protein/extracellular signal-regulated kinase (MEK) is well known to be associated with tumor invasion and metastasis. We…”
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Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice by Lin, Na, Liu, Chunfang, Xiao, Cheng, Jia, Hongwei, Imada, Keisuke, Wu, Hao, Ito, Akira

“…Chinese herbal remedy Tripterygium wilfordii Hook. f. (TWHF) has been reported to be therapeutically efficacious in the treatment of rheumatoid arthritis (RA),…”
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Progesterone increases the production of tissue inhibitor of metalloproteinases-2 in rabbit uterine cervical fibroblasts by Imada, Keisuke, Ito, Akira, Itoh, Yoshifumi, Nagase, Hideaki, Mori, Yo

“…Rabbit uterine cervical fibroblasts in culture produces tissue inhibitor of metalloproteinases (TIMP)-l and TIMP-2. When cells were treated with physiological…”
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A novel functional site of extracellular matrix metalloproteinase inducer (EMMPRIN) that limits the migration of human uterine cervical carcinoma cells by SATO, Takashi, WATANABE, Mami, HASHIMOTO, Kei, OTA, Tomoko, AKIMOTO, Noriko, IMADA, Keisuke, NOMIZU, Motoyoshi, ITO, Akira

“…EMMPRIN (extracellular matrix metalloproteinase inducer)/CD147, a membrane-bound glycoprotein with two extracellular loop domains (termed loops I and II),…”
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Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice by Imada, Keisuke, Lin, Na, Liu, Chunfang, Lu, Aiping, Chen, Weiheng, Yano, Masamichi, Sato, Takashi, Ito, Akira

“…Aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 have been shown to play crucial roles…”
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Hypolipidemic effect of 2-aminoethane sulfonic acid (taurine) in high fat/high cholesterol-loaded golden Syrian hamsters by Imada, Keisuke, Takenaga, Takaaki, Otomo, Susumu

“…It has been well known that 2-aminoethane sulfonic acid (taurine) has a hypolipidemic action in rat and mouse with hyperlipidemia. However, there is no report…”
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Activation of Human Progelatinase A/Promatrix Metalloproteinase 2 by Escherichia coli-Derived Serine Proteinase by Takeda, Mitsushi, Imada, Keisuke, Sato, Takashi, Ito, Akira

“…Treatment of human uterine cervical fibroblasts with commercial lipopolysaccharide (LPS) preparations from different serotypes of Escherichia coli effectively…”
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Hypolipidemic effect of taurine in golden Syrian hamsters by Takenaga, T, Imada, K, Otomo, S

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