Search Results - "Ima, Masaki"

Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma by Itadani, Satoshi, Yashiro, Kentaro, Aratani, Yoshiyuki, Sekiguchi, Tetsuya, Kinoshita, Atsushi, Moriguchi, Hideki, Ohta, Nobukazu, Takahashi, Shinya, Ishida, Akiharu, Tajima, Yohei, Hisaichi, Katsuya, Ima, Masaki, Ueda, Junya, Egashira, Hiromu, Sekioka, Tomohiko, Kadode, Michiaki, Yonetomi, Yasuo, Nakao, Takafumi, Inoue, Atsuto, Nomura, Hiroaki, Kitamine, Tetsuya, Fujita, Manabu, Nabe, Takeshi, Yamaura, Yoshiyuki, Matsumura, Naoya, Imagawa, Akira, Nakayama, Yoshisuke, Takeuchi, Jun, Ohmoto, Kazuyuki

“…An orally active dual CysLT1 and CysLT2 antagonist possessing a distinctive structure which consists of triple bond and dicarboxylic acid moieties is…”
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Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist by Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun

“…The benzoxazine derivative, (2S)-4-(3-carboxypropyl)-8-{[4-(4-phenylbutoxy)benzoyl]amino}-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid (19, ONO-2050297),…”
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Discovery of a potent, orally available dual CysLT1 and CysLT2 antagonist with dicarboxylic acid by Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Aratani, Yoshiyuki, Egashira, Hiromu, Matsumura, Naoya, Inoue, Atsuto, Yonetomi, Yasuo, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun

“…[Display omitted] A potent, orally available dual CysLT1 and CysLT2 receptor antagonist with a dicarboxylic acid is described…”
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Discovery of Gemilukast (ONO-6950), a Dual CysLT 1 and CysLT 2 Antagonist As a Therapeutic Agent for Asthma by Itadani, Satoshi, Yashiro, Kentaro, Aratani, Yoshiyuki, Sekiguchi, Tetsuya, Kinoshita, Atsushi, Moriguchi, Hideki, Ohta, Nobukazu, Takahashi, Shinya, Ishida, Akiharu, Tajima, Yohei, Hisaichi, Katsuya, Ima, Masaki, Ueda, Junya, Egashira, Hiromu, Sekioka, Tomohiko, Kadode, Michiaki, Yonetomi, Yasuo, Nakao, Takafumi, Inoue, Atsuto, Nomura, Hiroaki, Kitamine, Tetsuya, Fujita, Manabu, Nabe, Takeshi, Yamaura, Yoshiyuki, Matsumura, Naoya, Imagawa, Akira, Nakayama, Yoshisuke, Takeuchi, Jun, Ohmoto, Kazuyuki

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Discovery of Highly Potent Dual CysLT 1 and CysLT 2 Antagonist by Itadani, Satoshi, Takahashi, Shinya, Ima, Masaki, Sekiguchi, Tetsuya, Fujita, Manabu, Nakayama, Yoshisuke, Takeuchi, Jun

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Further optimization of sulfonamide analogs as EP1 receptor antagonists: Synthesis and evaluation of bioisosteres for the carboxylic acid group by Naganawa, Atsushi, Matsui, Toshiaki, Ima, Masaki, Saito, Tetsuji, Murota, Masayuki, Aratani, Yoshiyuki, Kijima, Hideomi, Yamamoto, Hiroshi, Maruyama, Takayuki, Ohuchida, Shuichi, Nakai, Hisao, Toda, Masaaki

“…Further optimization of 1 as EP1 antagonist afforded 2b, 8, and 16. 4-{[2-[(2-Furylsulfonyl)(isobutyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoic acid…”
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Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists by Naganawa, Atsushi, Matsui, Toshiaki, Ima, Masaki, Yoshida, Koji, Tsuruta, Hiroshi, Yamamoto, Shingo, Yamamoto, Hiroshi, Okada, Hiroki, Maruyama, Takayuki, Nakai, Hisao, Kondo, Kigen, Toda, Masaaki

“…Sulfonamide derivatives 13 and 15–17 were found to be highly potent and selective EP1 receptor antagonists. In vivo EP1 antagonist activity was also…”
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Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists by Naganawa, Atsushi, Matsui, Toshiaki, Saito, Tetsuji, Ima, Masaki, Tatsumi, Tadashi, Yamamoto, Shingo, Murota, Masayuki, Yamamoto, Hiroshi, Maruyama, Takayuki, Ohuchida, Shuichi, Nakai, Hisao, Kondo, Kigen, Toda, Masaaki

“…Heteroaryl sulfonamide derivatives 2–4 were identified as more potent and less lipophilic EP1 receptor antagonists than 1…”
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Enantioselective Synthesis of Lythraceae Alkaloid Lasubine II via Optically Active 2-Isoxazoline by Inomata, Katsuhiko, Ukaji, Yutaka, Imai, Masaki, Yamada, Takehito

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