Search Results - "Im, Michael M"

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development by Bester, Assaf C., Roniger, Maayan, Oren, Yifat S., Im, Michael M., Sarni, Dan, Chaoat, Malka, Bensimon, Aaron, Zamir, Gideon, Shewach, Donna S., Kerem, Batsheva

“…Chromosomal instability in early cancer stages is caused by stress on DNA replication. The molecular basis for replication perturbation in this context is…”
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Folate levels modulate oncogene‐induced replication stress and tumorigenicity by Lamm, Noa, Maoz, Karin, Bester, Assaf C, Im, Michael M, Shewach, Donna S, Karni, Rotem, Kerem, Batsheva

“…Chromosomal instability in early cancer stages is caused by replication stress. One mechanism by which oncogene expression induces replication stress is to…”
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Mutagenesis of Basic Residues R151 and R161 in Manganese-Stabilizing Protein of Photosystem II Causes Inefficient Binding of Chloride to the Oxygen-Evolving Complex by Popelkova, Hana, Betts, Scott D., Lydakis-Symantiris, Nikos, Im, Michael M., Swenson, Ellen, Yocum, Charles F.

“…Manganese-stabilizing protein of photosystem II, an intrinsically disordered polypeptide, contains a high ratio of charged to hydrophobic amino acid residues…”
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Late DNA Damage Mediated by Homologous Recombination Repair Results in Radiosensitization with Gemcitabine by Im, Michael M., Flanagan, Sheryl A., Ackroyd, Jeffrey J., Knapp, Brendan, Kramer, Aaron, Shewach, Donna S.

“…Gemcitabine (dFdCyd) shows broad antitumor activity in solid tumors in chemotherapeutic regimens or when combined with ionizing radiation (radiosensitization)…”
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Drug Metabolism and Homologous Recombination Repair in Radiosensitization with Gemcitabine by Im, Michael M., Flanagan, Sheryl A., Ackroyd, Jeffrey J., Shewach, Donna S.

“…Gemcitabine (difluorodeoxycytidine; dFdCyd) is a potent radiosensitizer, noted for its ability to enhance cytotoxicity with radiation at noncytotoxic…”
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N-Terminus of the Photosystem II Manganese Stabilizing Protein:  Effects of Sequence Elongation and Truncation by Popelkova, Hana, Im, Michael M, D'Auria, John, Betts, Scott D, Lydakis-Simantiris, Nikos, Yocum, Charles F

“…The importance of the N-terminal domain of manganese stabilizing protein in binding to photosystem II has been previously demonstrated [Eaton-Rye and Murata…”
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A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy by BOUCHER, Paul D, IM, Michael M, FREYTAG, Svend O, SHEWACH, Donna S

“…The combination of cytosine deaminase (CD) and herpes simplex virus thymidine kinase (HSV-TK) suicide gene protocols has resulted in enhanced antitumor…”
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Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT116 cells by ROBINSON, Blaine W, IM, Michael M, LJUNGMAN, Mats, PRAZ, Francoise, SHEWACH, Donna S

“…Gemcitabine [2',2'-difluoro-2'-deoxycytidine (dFdCyd)] is a potent ionizing radiation sensitizer in solid tumor cells in vitro and in vivo. Previously, we have…”
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Promising combination therapies with gemcitabine by Robinson, Blaine W, Ostruszka, Leo, Im, Michael M, Shewach, Donna S

“…Because treatment regimens for breast cancer commonly include gemcitabine, we evaluated two promising combinations in preclinical studies: gemcitabine (Gemzar;…”
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Binding of Manganese Stabilizing Protein to Photosystem II:  Identification of Essential N-Terminal Threonine Residues and Domains that Prevent Nonspecific Binding by Popelkova, Hana, Im, Michael M., Yocum, Charles F.

“…The N-terminus of spinach photosystem II manganese stabilizing protein (MSP) contains two amino acid sequences, 4KRLTYD10E and 15TYL18E, that are necessary for…”
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N-Terminal Truncations of Manganese Stabilizing Protein Identify Two Amino Acid Sequences Required for Binding of the Eukaryotic Protein to Photosystem II and Reveal the Absence of One Binding-Related Sequence in Cyanobacteria by Popelkova, Hana, Im, Michael M, Yocum, Charles F

“…Manganese stabilizing protein (MSP) is an intrinsically disordered extrinsic subunit of photosystem II that regulates the stability and kinetic performance of…”
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Abstract 1316: Late-occurring DNA damage is responsible for radiosensitization with gemcitabine by Im, Michael M., Flanagan, Sheryl A., Ladd, Brendon P., Shewach, Donna S.

“…Abstract Gemcitabine (2’,2’-difluoro-2’-deoxycytidine; dFdCyd) has excellent activity in the treatment of a variety of solid malignancies. After transport into…”
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Somatic Hypermutations Confer Rheumatoid Factor Activity in Hepatitis C Virus–Associated Mixed Cryoglobulinemia by Charles, Edgar D., Orloff, Michael I. M., Nishiuchi, Eiko, Marukian, Svetlana, Rice, Charles M., Dustin, Lynn B.

“…Objective Hepatitis C virus (HCV) is the most frequent cause of mixed cryoglobulinemia (MC), which is characterized by endothelial deposition of rheumatoid…”
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The role of oxygen-free radicals in ischemic tissue injury in island skin flaps by Manson, P N, Anthenelli, R M, Im, M J, Bulkley, G B, Hoopes, J E

“…The contribution of free radical-mediated reperfusion injury to the ischemic damage caused by total venous occlusion of island skin flaps was investigated in a…”
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A flow cytometry-based strategy to identify and express IgM from VH1-69 + clonal peripheral B cells by Charles, Edgar D., Orloff, Michael I.M., Dustin, Lynn B.

“…Pathologic rheumatoid factor (RF) levels are hallmarks of several human diseases. Production of monoclonal RF in vitro is essential for studies of the…”
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Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps by IM, M. J, MANSON, P. N, BULKLEY, G. B, HOOPES, J. E

“…We have demonstrated previously that oxygen-derived free radicals are important mediators of tissue injury following ischemia (total venous occlusion) and…”
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Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery by Schippers, Emile F., Berbée, Jimmy F. P., van Disseldorp, Inge M., Versteegh, Michael I. M., Havekes, Louis M., Rensen, Patrick C. N., van Dissel, Jaap T.

“…Objective Experimental models show that apolipoprotein CI (apoCI) binds and enhances the inflammatory response to endotoxin. We studied in patients undergoing…”
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Promising combination therapies with gemcitabine: Gemcitabine and Docetaxel in Metastatic and Neoadjuvant Treatment of Breast Cancer by ROBINSON, Blaine W, OSTRUSZKA, Leo, IM, Michael M, SHEWACH, Donna S

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DISTRIBUTION OF DEHYDROGENASES IN THE SKIN OF THE RHESUS MONKEY (MACACA MULATTA) by IM, MICHAEL J. C

“…The activities of the following dehydrogenase systems were demonstrated in the skin of the rhesus monkey (Macaca mulatta): succinic, malic, isocitric (DPN and…”
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Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids by Im, M J, Mulliken, J B, Hoopes, J E

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