Search Results - "Im, Michael"

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development by Bester, Assaf C., Roniger, Maayan, Oren, Yifat S., Im, Michael M., Sarni, Dan, Chaoat, Malka, Bensimon, Aaron, Zamir, Gideon, Shewach, Donna S., Kerem, Batsheva

“…Chromosomal instability in early cancer stages is caused by stress on DNA replication. The molecular basis for replication perturbation in this context is…”
Get full text

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells by Mannava, Sudha, Grachtchouk, Vladimir, Wheeler, Linda J., Im, Michael, Zhuang, Dazhong, Slavina, Elena G., Mathews, Christopher K., Shewach, Donna S., Nikiforov, Mikhail A.

“…To identify C-MYC targets rate-limiting for proliferation of malignant melanoma, we stably inhibited C-MYC in several human metastatic melanoma lines via…”
Get full text

Folate levels modulate oncogene‐induced replication stress and tumorigenicity by Lamm, Noa, Maoz, Karin, Bester, Assaf C, Im, Michael M, Shewach, Donna S, Karni, Rotem, Kerem, Batsheva

“…Chromosomal instability in early cancer stages is caused by replication stress. One mechanism by which oncogene expression induces replication stress is to…”
Get full text

Late DNA Damage Mediated by Homologous Recombination Repair Results in Radiosensitization with Gemcitabine by Im, Michael M., Flanagan, Sheryl A., Ackroyd, Jeffrey J., Knapp, Brendan, Kramer, Aaron, Shewach, Donna S.

“…Gemcitabine (dFdCyd) shows broad antitumor activity in solid tumors in chemotherapeutic regimens or when combined with ionizing radiation (radiosensitization)…”
Get full text

Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall by Day, Sharlene M., Reeve, Jennifer L., Pedersen, Brian, Farris, Diana M, Myers, Daniel D., Im, Michael, Wakefield, Thomas W., Mackman, Nigel, Fay, William P.

“…Leukocytes and leukocyte-derived microparticles contain low levels of tissue factor (TF) and incorporate into forming thrombi. Although this circulating pool…”
Get full text

Drug Metabolism and Homologous Recombination Repair in Radiosensitization with Gemcitabine by Im, Michael M., Flanagan, Sheryl A., Ackroyd, Jeffrey J., Shewach, Donna S.

“…Gemcitabine (difluorodeoxycytidine; dFdCyd) is a potent radiosensitizer, noted for its ability to enhance cytotoxicity with radiation at noncytotoxic…”
Get full text

A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy by BOUCHER, Paul D, IM, Michael M, FREYTAG, Svend O, SHEWACH, Donna S

“…The combination of cytosine deaminase (CD) and herpes simplex virus thymidine kinase (HSV-TK) suicide gene protocols has resulted in enhanced antitumor…”
Get full text

Mutation and Genomic Deletion Status of ataxia telangiectasia mutated (ATM) and p53 Confer Specific Gene Expression Profiles in Mantle Cell Lymphoma by Greiner, Timothy C., Dasgupta, Chiranjib, Ho, Vincent V., Weisenburger, Dennis D., Smith, Lynette M., Lynch, James C., Vose, Julie M., Fu, Kai, Armitage, James O., Braziel, Rita M., Campo, Elias, Delabie, Jan, Gascoyne, Randy D., Jaffe, Elaine S., Muller-Hermelink, Hans K., Ott, German, Rosenwald, Andreas, Staudt, Louis M., Im, Michael Y., Karaman, Mazen W., Pike, Brian L., Chan, Wing C., Hacia, Joseph G.

“…Although mantle cell lymphoma (MCL) frequently harbors inactivated ataxia telangiectasia mutated (ATM) and p53 alleles, little is known about the molecular…”
Get full text

Duplex Doppler Sonography: Is There Clinical Relevance to Elevated Renal Vein Velocity in Kidney Transplants? by Gulati, Mittul, Palmer, Suzanne L, Im, Michael Y, Jadvar, Hossein, Qazi, Yasir A, Fazli, Umer, Grant, Edward G

“…Abstract Purpose Determine a velocity threshold in the main renal vein (MRV) of renal transplants and evaluate the cause and clinical significance of elevated…”
Get full text

Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT116 cells by ROBINSON, Blaine W, IM, Michael M, LJUNGMAN, Mats, PRAZ, Francoise, SHEWACH, Donna S

“…Gemcitabine [2',2'-difluoro-2'-deoxycytidine (dFdCyd)] is a potent ionizing radiation sensitizer in solid tumor cells in vitro and in vivo. Previously, we have…”
Get full text

Mutagenesis of Basic Residues R151 and R161 in Manganese-Stabilizing Protein of Photosystem II Causes Inefficient Binding of Chloride to the Oxygen-Evolving Complex by Popelkova, Hana, Betts, Scott D., Lydakis-Symantiris, Nikos, Im, Michael M., Swenson, Ellen, Yocum, Charles F.

“…Manganese-stabilizing protein of photosystem II, an intrinsically disordered polypeptide, contains a high ratio of charged to hydrophobic amino acid residues…”
Get full text

N-Terminus of the Photosystem II Manganese Stabilizing Protein:  Effects of Sequence Elongation and Truncation by Popelkova, Hana, Im, Michael M, D'Auria, John, Betts, Scott D, Lydakis-Simantiris, Nikos, Yocum, Charles F

“…The importance of the N-terminal domain of manganese stabilizing protein in binding to photosystem II has been previously demonstrated [Eaton-Rye and Murata…”
Get full text

Promising combination therapies with gemcitabine by Robinson, Blaine W, Ostruszka, Leo, Im, Michael M, Shewach, Donna S

“…Because treatment regimens for breast cancer commonly include gemcitabine, we evaluated two promising combinations in preclinical studies: gemcitabine (Gemzar;…”
Get full text

Fixation of the Craniofacial Skeleton with Butyl-2-Cyanoacrylate and Its Effects on Histotoxicity and Healing by Shermak, Michele A, Wong, Lesley, Inoue, Nozumu, Crain, Barbara J, Im, Michael J, Chao, Edmund Y. S, Manson, Paul N

“…Butyl-2-cyanoacrylate is an easily applied, biocompatible, bioresorbable polymer glue that provides an alternative to conventional rigid fixation techniques…”
Get full text

Binding of Manganese Stabilizing Protein to Photosystem II:  Identification of Essential N-Terminal Threonine Residues and Domains that Prevent Nonspecific Binding by Popelkova, Hana, Im, Michael M., Yocum, Charles F.

“…The N-terminus of spinach photosystem II manganese stabilizing protein (MSP) contains two amino acid sequences, 4KRLTYD10E and 15TYL18E, that are necessary for…”
Get full text

Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence by Mannava, Sudha, Moparthy, Kalyana C, Wheeler, Linda J, Natarajan, Venkatesh, Zucker, Shoshanna N, Fink, Emily E, Im, Michael, Flanagan, Sheryl, Burhans, William C, Zeitouni, Nathalie C, Shewach, Donna S, Mathews, Christopher K, Nikiforov, Mikhail A

“…In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response. Oxidative stress and hyperreplication of genomic DNA have…”
Get full text

N-Terminal Truncations of Manganese Stabilizing Protein Identify Two Amino Acid Sequences Required for Binding of the Eukaryotic Protein to Photosystem II and Reveal the Absence of One Binding-Related Sequence in Cyanobacteria by Popelkova, Hana, Im, Michael M, Yocum, Charles F

“…Manganese stabilizing protein (MSP) is an intrinsically disordered extrinsic subunit of photosystem II that regulates the stability and kinetic performance of…”
Get full text

Enzymatic Activation Associated with Programmed Fusion of the Posterior Interfrontal Sutures in Rats by Winograd, Jonathan M, Im, Michael J, Kolk, Craig A. Vander

“…Fetal rat coronal sutures in culture undergo fusion in the absence of their dura mater. Coinciding with the period of fusion are marked cellular enzymatic…”
Get full text

Somatic Hypermutations Confer Rheumatoid Factor Activity in Hepatitis C Virus–Associated Mixed Cryoglobulinemia by Charles, Edgar D., Orloff, Michael I. M., Nishiuchi, Eiko, Marukian, Svetlana, Rice, Charles M., Dustin, Lynn B.

“…Objective Hepatitis C virus (HCV) is the most frequent cause of mixed cryoglobulinemia (MC), which is characterized by endothelial deposition of rheumatoid…”
Get full text

Thickness of the Meniscal Lamellar Layer: Correlation with Indentation Stiffness and Comparison of Normal and Abnormally Thick Layers by Using Multiparametric Ultrashort Echo Time MR Imaging by Choi, Ja-Young, Biswas, Reni, Bae, Won C, Healey, Robert, Im, Michael, Statum, Sheronda, Chang, Eric Y, Du, Jiang, Bydder, Graeme M, D'Lima, Darryl, Chung, Christine B

“…Purpose To determine the relationship between lamellar layer thickness on ultrashort echo time (UTE) magnetic resonance (MR) images and indentation stiffness…”
Get full text