Search Results - "Im, Haeri"

Effect of linker on the binding free energy of stapled p53/HDM2 complex by Im, Haeri, Ham, Sihyun

“…Inactivation of the tumor suppressor p53 resulting from the binding with a negative regulator HDM2 is among the predominant defects in human cancers…”
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Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization by Diebold-Durand, Marie-Laure, Lee, Hansol, Ruiz Avila, Laura B., Noh, Haemin, Shin, Ho-Chul, Im, Haeri, Bock, Florian P., Bürmann, Frank, Durand, Alexandre, Basfeld, Alrun, Ham, Sihyun, Basquin, Jérôme, Oh, Byung-Ha, Gruber, Stephan

“…Multi-subunit SMC complexes control chromosome superstructure and promote chromosome disjunction, conceivably by actively translocating along DNA double…”
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A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Inhibitors of Intracellular Protein-Protein Interactions by Epitope and Arginine Grafting by Fujiwara, Daisuke, Kitada, Hidekazu, Oguri, Masahiro, Nishihara, Toshio, Michigami, Masataka, Shiraishi, Kazunori, Yuba, Eiji, Nakase, Ikuhiko, Im, Haeri, Cho, Sunhee, Joung, Jong Young, Kodama, Seiji, Kono, Kenji, Ham, Sihyun, Fujii, Ikuo

“…The design of inhibitors of intracellular protein–protein interactions (PPIs) remains a challenge in chemical biology and drug discovery. We propose a cyclized…”
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Explicit Characterization of the Free Energy Landscape of pKID–KIX Coupled Folding and Binding by Chong, Song-Ho, Im, Haeri, Ham, Sihyun

“…The most fundamental aspect of the free energy landscape of proteins is that it is globally funneled such that protein folding is energetically biased. Then,…”
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Role of electrostatic interactions in determining the G-quadruplex structures by Lee, Jinkeong, Im, Haeri, Chong, Song-Ho, Ham, Sihyun

“…[Display omitted] •We investigate the energetics of three representative G-quadruplex structures.•Conformational energy and solvation free energy correlate…”
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A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Inhibitors of Intracellular Protein-Protein Interactions by Epitope and Arginine Grafting by Fujiwara, Daisuke, Kitada, Hidekazu, Oguri, Masahiro, Nishihara, Toshio, Michigami, Masataka, Shiraishi, Kazunori, Yuba, Eiji, Nakase, Ikuhiko, Im, Haeri, Cho, Sunhee, Joung, Jong Young, Kodama, Seiji, Kono, Kenji, Ham, Sihyun, Fujii, Ikuo

“…The design of inhibitors of intracellular protein–protein interactions (PPIs) remains a challenge in chemical biology and drug discovery. We propose a cyclized…”
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Characterizing the structural and thermodynamic properties of Aβ42 and Aβ40 by Lin, Yuxi, Im, Haeri, Diem, Le Thi, Ham, Sihyun

“…The self-assembly of amyloid-beta (Aβ) proteins in aqueous extracellular environments is implicated in Alzheimer's disease. Among several alloforms of Aβ…”
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