Search Results - "Ilyinskii, Petr O."

Enhancement of the Tolerogenic Phenotype in the Liver by ImmTOR Nanoparticles by Ilyinskii, Petr O, Roy, Christopher J, LePrevost, Julie, Rizzo, Gina L, Kishimoto, Takashi Kei

“…ImmTOR biodegradable nanoparticles encapsulating rapamycin have been shown to induce a durable tolerogenic immune response to co-administered biologics and…”
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Novel Prefrontal Synthesis Intervention Improves Language in Children with Autism by Vyshedskiy, Andrey, Khokhlovich, Edward, Dunn, Rita, Faisman, Alexander, Elgart, Jonah, Lokshina, Lisa, Gankin, Yuriy, Ostrovsky, Simone, deTorres, Lauren, Edelson, Stephen M, Ilyinskii, Petr O

“…Prefrontal synthesis (PFS) is defined as the ability to juxtapose mental visuospatial objects at will. Paralysis of PFS may be responsible for the lack of…”
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Synthetic vaccine particles for durable cytolytic T lymphocyte responses and anti-tumor immunotherapy by Ilyinskii, Petr O, Kovalev, Grigoriy I, O'Neil, Conlin P, Roy, Christopher J, Michaud, Alicia M, Drefs, Natalia M, Pechenkin, Mikhail A, Fu, Fen-Ni, Johnston, Lloyd P M, Ovchinnikov, Dmitry A, Kishimoto, Takashi Kei

“…We previously reported that synthetic vaccine particles (SVP) encapsulating antigens and TLR agonists resulted in augmentation of immune responses with minimal…”
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ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia by Ilyinskii, Petr O., Michaud, Alicia M., Rizzo, Gina L., Roy, Christopher J., Leung, Sheldon S., Elkins, Stephanie L., Capela, Teresa, Chowdhury, Aparajita, Li, Lina, Chandler, Randy J., Manoli, Irini, Andres-Mateos, Eva, Johnston, Lloyd P.M., Vandenberghe, Luk H., Venditti, Charles P., Kishimoto, Takashi Kei

“…A major barrier to adeno-associated virus (AAV) gene therapy is the inability to re-dose patients due to formation of vector-induced neutralizing antibodies…”
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Toxicity of Influenza A Virus Matrix Protein 2 for Mammalian Cells is Associated with its Intrinsic Proton-Channeling Activity by Ilyinskii, Petr O., Gabai, Vladimir L., Sunyaev, Shamil R., Thoidis, Galini, Shneider, Alexander M.

“…Molecules of influenza matrix protein 2 (M2) are organized in tetramers that constitute a well-conserved virion component and also form proton channels in the…”
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CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) In Vitro and Immune Response to EMCV Infection In Vivo by ILYINSKII, Petr O, WANE, Ruojie, BALK, Steven P, EXLEY, Mark A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release by Ilyinskii, Petr O, Roy, Christopher J, O’Neil, Conlin P, Browning, Erica A, Pittet, Lynnelle A, Altreuter, David H, Alexis, Frank, Tonti, Elena, Shi, Jinjun, Basto, Pamela A, Iannacone, Matteo, Radovic-Moreno, Aleksandar F, Langer, Robert S, Farokhzad, Omid C, von Andrian, Ulrich H, Johnston, Lloyd P.M, Kishimoto, Takashi Kei

“…Abstract Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many…”
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Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease by Kishimoto, Takashi Kei, Fournier, Max, Michaud, Alicia, Rizzo, Gina, Roy, Christopher, Capela, Teresa, Nukolova, Natasha, Li, Ning, Doyle, Liam, Fu, Fen-ni, VanDyke, Derek, Traber, Peter G., Spangler, Jamie B., Leung, Sheldon S., Ilyinskii, Petr O.

“…Interleukin-2 (IL-2) therapies targeting the high affinity IL-2 receptor expressed on regulatory T cells (Tregs) have shown promising therapeutic benefit in…”
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Inhibition of influenza M2-induced cell death alleviates its negative contribution to vaccination efficiency by Ilyinskii, Petr O, Gambaryan, Alexandra S, Meriin, Anatoli B, Gabai, Vladimir, Kartashov, Alex, Thoidis, Galini, Shneider, Alexander M

“…The effectiveness of recombinant vaccines encoding full-length M2 protein of influenza virus or its ectodomain (M2e) have previously been tested in a number of…”
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Readministration of high-dose adeno-associated virus gene therapy vectors enabled by ImmTOR nanoparticles combined with B cell-targeted agents by Ilyinskii, Petr O, Roy, Christopher, Michaud, Alicia, Rizzo, Gina, Capela, Teresa, Leung, Sheldon S, Kishimoto, Takashi Kei

“…Abstract Tolerogenic ImmTOR nanoparticles encapsulating rapamycin have been demonstrated to mitigate immunogenicity of adeno-associated virus (AAV) gene…”
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Enhancement of liver-directed transgene expression at initial and repeat doses of AAV vectors admixed with ImmTOR nanoparticles by Ilyinskii, Petr O, Michaud, Alicia M, Roy, Christopher J, Rizzo, Gina L, Elkins, Stephanie L, Capela, Teresa, Chowdhury, Aparajita C, Leung, Sheldon S, Kishimoto, Takashi K

“…Systemic AAV (adeno-associated virus) gene therapy is a promising approach for the treatment of inborn errors of metabolism, but questions remain regarding its…”
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Development of a Vaccine Against Pandemic Influenza Viruses: Current Status and Perspectives by Ilyinskii, Petr O., Thoidis, Galini, Shneider, Alexander M.

“…The constant threat of a new influenza pandemic, which may be caused by a highly pathogenic avian influenza virus, necessitates the development of a vaccine…”
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Importance of mRNA secondary structural elements for the expression of influenza virus genes by Ilyinskii, Petr O, Schmidt, Thorsten, Lukashev, Dmitry, Meriin, Anatoli B, Thoidis, Galini, Frishman, Dmitrij, Shneider, Alexander M

“…Development of novel vaccines and therapeutics often requires efficient expression of recombinant viral proteins. Here we show that mutations in essential…”
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The proteosomal degradation of fusion proteins cannot be predicted from the proteosome susceptibility of their individual components by Ilyinskii, Petr O., Meriin, Anatoli B., Gabai, Vladimir L., Usachev, Evgeny V., Prilipov, Alexei G., Thoidis, Galini, Shneider, Alexander M.

“…It is assumed that the proteosome‐processing characteristics of fusion constructs can be predicted from the sum of the proteosome sensitivity of their…”
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Protection against mouse and avian influenza A strains via vaccination with a combination of conserved proteins NP, M1 and NS1 by Zhirnov, Oleg P., Isaeva, Elena I., Konakova, Tatyana E., Thoidis, Galini, Piskareva, Lyudmila M., Akopova, Irina I., Kartashov, Alex, Altstein, Anatoly D., Ilyinskii, Petr O., Shneider, Alexander M.

“…Background  Experimental data accumulated over more than a decade indicate that cross‐strain protection against influenza may be achieved by immunization with…”
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Effective expression of recombinant cytotoxic protein via its attachment to a polyglutamine domain by Ilyinskii, Petr O, Nurminskaya, Maria V, Gabai, Vladimir L, Prilipov, Alexei G, Usachev, Evgeny V, Zakharova, Lyudmila G, Thoidis, Galini, Altstein, Anatoly D, Shneider, Alexander M

“…Inadvertent cytotoxicity may hinder the expression of many recombinant proteins that are of industrial or medicinal importance. Here, we show that covalent…”
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Association of Simian Virus 40 with a Central Nervous System Lesion Distinct from Progressive Multifocal Leukoencephalopathy in Macaques with AIDS by Simon, Meredith A., Ilyinskii, Petr O., Baskin, Gary B., Knight, Heather Y., Pauley, Douglas R., Lackner, Andrew A.

“…The primate polyomavirus SV40 is known to cause interstitial nephritis in primary infections and progressive multifocal leukoencephalopathy (PML) upon…”
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Sequences Just Upstream of the Simian Immunodeficiency Virus Core Enhancer Allow Efficient Replication in the Absence of NF-κB and Sp1 Binding Elements by Pöhlmann, Stefan, Flöss, Stefan, Ilyinskii, Petr O., Stamminger, Thomas, Kirchhoff, Frank

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A malignant astrocytoma containing simian virus 40 DNA in a macaque infected with simian immunodeficiency virus by Hurley, John P., Ilyinskii, Petr O., Horvath, Christopher J., Simon, Meredith A.

“…: Polyomaviruses have proven oncogenicity in nonhost experimental animals; however, studies concerning the association between human brain tumors and simian…”
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Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys by Du, Zhenjian, Lang, Sabine M., Sasseville, Vito G., Lackner, Andrew A., Ilyinskii, Petr O., Daniel, Muthiah D., Jung, Jae U., Desrosiers, Ronald C.

“…Residues 17 and 18 In nef of SIVmac239 were changed from RQ to YE to create a translated sequence of SRP-SGDLYERLLRARGETYGRLLGEVEDGYSOSP from residues 10–43…”
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