Search Results - "Ilyin, Sergey E"

Biomarker discovery and validation: technologies and integrative approaches by Ilyin, Sergey E., Belkowski, Stanley M., Plata-Salamán, Carlos R.

“…The emerging field of biomarkers has applications in the diagnosis, staging, prognosis and monitoring of disease progression, as well as in the monitoring of…”
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Nanoliter high-throughput RT-qPCR: a statistical analysis and assessment by Dixon, James M, Lubomirski, Mariusz, Amaratunga, Dhammika, Morrison, Tom B, Brenan, Colin J H, Ilyin, Sergey E

“…Biomarkers discovered from gene expression profiles using hybridization microarrays have made great inroads in the diagnosis and development of safer and…”
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Nanoliter high throughput quantitative PCR by Morrison, Tom, Hurley, James, Garcia, Javier, Yoder, Karl, Katz, Arrin, Roberts, Douglas, Cho, Jamie, Kanigan, Tanya, Ilyin, Sergey E, Horowitz, Daniel, Dixon, James M, Brenan, Colin J.H

“…Understanding biological complexity arising from patterns of gene expression requires accurate and precise measurement of RNA levels across large numbers of…”
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Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells by Plata-Salamán, C R, Ilyin, S E, Gayle, D

“…Cancer is consistently associated with anorexia. The Lobund-Wistar rat model of prostate cancer exhibits clinical manifestations (including anorexia) that…”
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Feeding status and bacterial LPS-induced cytokine and neuropeptide gene expression in hypothalamus by Gayle, D, Ilyin, S E, Plata-Salamán, C R

“…This study determined the effects of feeding status on basal and lipopolysaccharide (LPS)-stimulated cytokine and neuropeptide gene expression in the…”
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Persistent Borna disease virus infection of neonatal rats causes brain regional changes of mRNAs for cytokines, cytokine receptor components and neuropeptides by Plata-Salamán, Carlos R, Ilyin, Sergey E, Gayle, Dave, Romanovitch, Anna, Carbone, Kathryn M

“…Borna disease virus (BDV) replicates in brain cells. The neonatally infected rat with BDV exhibits developmental-neuromorphological abnormalities, neuronal…”
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Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide by Turrin, Nicolas P, Gayle, Dave, Ilyin, Sergey E, Flynn, Mark C, Langhans, Wolfgang, Schwartz, Gary J, Plata-Salamán, Carlos R

“…Gram-negative bacteria-derived lipopolysaccharide (LPS or endotoxin) is known to play an important role in immune and neurological manifestations during…”
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Levels of mRNA coding for alpha-, beta-, and gamma-synuclein in the brains of newborn, juvenile, and adult rats by Malatynska, Ewa, Pinhasov, Albert, Crooke, Jeffrey, Horowitz, Daniel, Brenneman, Douglas E, Ilyin, Sergey E

“…Synucleins are proteins known for their malfunction in a group of illnesses called synucleopathies, which includes Alzheimer's and Parkinson's disease. To…”
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Interleukin-1β system in anorectic catabolic tumor-bearing rats by Turrin, Nicolas P, Ilyin, Sergey E, Gayle, Dave A, Plata-Salamán, Carlos R, Ramos, Eduardo JB, Laviano, Alessandro, Das, Undurti N, Inui, Akio, Meguid, Michael M

“…PURPOSE OF REVIEWThe onset of cancer anorexia and the accompanying neurological symptoms and signs involve the general influence of cytokines on the brain…”
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Neither acute nor chronic exposure to a naturalistic (predator) stressor influences the interleukin-1β system, tumor necrosis factor-α, transforming growth factor-β1, and neuropeptide mRNAs in specific brain regions by Plata-Salamán, Carlos R, Ilyin, Sergey E, Turrin, Nicolas P, Gayle, Dave, Flynn, Mark C, Bedard, Tanya, Merali, Zul, Anisman, Hymie

“…Physical (neurogenic) stressors may influence immune functioning and interleukin-1β (IL-1β) mRNA levels within several brain regions. The present study…”
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Kindling modulates the IL-1β system, TNF-α, TGF-β1, and neuropeptide mRNAs in specific brain regions by Plata-Salamán, Carlos R, Ilyin, Sergey E, Turrin, Nicolas P, Gayle, Dave, Flynn, Mark C, Romanovitch, Anna E, Kelly, Mary E, Bureau, Yves, Anisman, Hymie, McIntyre, Dan C

“…Cytokines and neuropeptides may be involved in seizure-associated processes. Following amygdala kindling in rats, we determined alterations of IL-1β, IL-1…”
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Interleukin-1β System (Ligand, Receptor Type I, Receptor Accessory Protein and Receptor Antagonist), TNF-α, TGF-β1 and Neuropeptide Y mRNAs in Specific Brain Regions During Bacterial LPS-Induced Anorexia by Ilyin, Sergey E, Gayle, Dave, Flynn, Mark C, Plata-Salamán, Carlos R

“…Bacterial lipopolysaccharide (LPS) or endotoxin induces neurological manifestations including anorexia. It is proposed that LPS-induced cytokine production is…”
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High-throughput siRNA-based functional target validation by Xin, Hong, Bernal, Alejandro, Amato, Frank A, Pinhasov, Albert, Kauffman, Jack, Brenneman, Douglas E, Derian, Claudia K, Andrade-Gordon, Patricia, Plata-Salamán, Carlos R, Ilyin, Sergey E

“…The drug discovery process pursued by major pharmaceutical companies for many years starts with target identification followed by high-throughput screening…”
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Considerations for target validation and industrial approaches by Plata-Salamán, Carlos R, Ilyin, Sergey E

“…Target validation in health and disease integrates the modulation of a certain molecular target with an expected biological/biochemical/physiological or…”
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Integrated expressional analysis: Application to the drug discovery process by Ilyin, Sergey E., Horowitz, Daniel, Belkowski, Stanley M., Xin, Hong, Eckardt, Annette J., Darrow, Andrew L., Chen, Cailin, Maley, Derrick, D’Andrea, Michael, Plata-Salamán, Carlos R., Derian, Claudia K.

“…Microarray technology enables high-throughput testing of gene expression to investigate various neuroscience related questions. This in turn creates a demand…”
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Functional informatics: convergence and integration of automation and bioinformatics by Ilyin, Sergey E, Bernal, Alejandro, Horowitz, Daniel, Derian, Claudia K, Xin, Hong

“…The biopharmaceutical industry is currently being presented with opportunities to improve research and business efficiency via automation and the integration…”
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Multiplexed RT- PCR for high throughput screening applications by Maley, Derrick, Mei, Jay, Lu, Hong, Johnson, Dana L, Ilyin, Sergey E

“…To increase efficiency of high throughput gene expression profiling, we established a new TaqMan RT-PCR (real-time reverse transcriptase-polymerase chain…”
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Fiber-optic monitoring coupled with confocal microscopy for imaging gene expression in vitro and in vivo by Ilyin, Sergey E., Flynn, Mark C., Plata-Salamán, Carlos R.

“…Detection of fluorescent signals in living cells is a common and powerful technique used to monitor gene expression for multiple biomedical applications. A…”
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Gene expression analysis for high throughput screening applications by Pinhasov, Albert, Mei, Jay, Amaratunga, Dhammika, Amato, Frank A, Lu, Hong, Kauffman, Jack, Xin, Hong, Brenneman, Douglas E, Johnson, Dana L, Andrade-Gordon, Patricia, Ilyin, Sergey E

“…To meet growing needs for high throughput gene expression profiling, we established a new automated high throughput TaqMan RT-PCR method for quantitative mRNA…”
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Autoregulation of the interleukin-1 system and cytokine–cytokine interactions in primary human astrocytoma cells by Ilyin, Sergey E, González-Gómez, Ignacio, Romanovicht, Anna, Gayle, Dave, Gilles, Floyd H, Plata-Salamán, Carlos R

“…Cytokines are proposed to play important roles in brain tumor biology. Previous studies reported on interleukin-1β (IL-1β) production and IL-1 receptor type I…”
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