Search Results - "Ilnytska, Olga"

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid by McCauliff, Leslie A, Langan, Annette, Li, Ran, Ilnytska, Olga, Bose, Debosreeta, Waghalter, Miriam, Lai, Kimberly, Kahn, Peter C, Storch, Judith

“…Unesterified cholesterol accumulation in the late endosomal/lysosomal (LE/LY) compartment is the cellular hallmark of Niemann-Pick C (NPC) disease, caused by…”
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Structure-function relationships of cholesterol mobilization from the endo-lysosome compartment of NPC1-deficient human cells by β-CD polyrotaxanes by Samaddar, Shayak, Bose, Debosreeta, Loren, Bradley P, Skulsky, Joseph L, Ilnytska, Olga, Struzik, Zachary J, Storch, Judith, Thompson, David H

“…Niemann-Pick Type C is a rare metabolic disorder characterized by the cellular accumulation of cholesterol within endosomal and lysosomal compartments…”
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Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy by ILNYTSKA, Olga, LYZOGUBOV, Valeriy V, STEVENS, Martin J, DREL, Viktor R, MASHTALIR, Nazar, PACHER, Pal, YOREK, Mark A, OBROSOVA, Irina G

“…Poly(ADP-Ribose) Polymerase Inhibition Alleviates Experimental Diabetic Sensory Neuropathy Olga Ilnytska 1 , Valeriy V. Lyzogubov 1 , Martin J. Stevens 2 ,…”
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PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy by Obrosova, Irina G., Xu, Weizheng, Lyzogubov, Valeriy V., Ilnytska, Olga, Mashtalir, Nazar, Vareniuk, Igor, Pavlov, Ivan A., Zhang, Jie, Slusher, Barbara, Drel, Viktor R.

“…Evidence that poly(ADP-ribose) polymerase (PARP) activation plays an important role in diabetic complications is emerging. This study evaluated the role of…”
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A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice by Drel, Viktor R., Pacher, Pal, Vareniuk, Igor, Pavlov, Ivan, Ilnytska, Olga, Lyzogubov, Valeriy V., Tibrewala, Jyoti, Groves, John T., Obrosova, Irina G.

“…Whereas an important role of free radicals and oxidants in peripheral diabetic neuropathy is well established, the contribution of nitrosative stress and, in…”
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Nonlinear Parabolic Variational Inequalities with Variable Time-Delay in Time Unbounded Domains by Bokalo, Mykola M., Ilnytska, Olga V., Bokalo, Taras M.

“…We research the well-posedness of the problem without initial condition for nonlinear parabolic variational inequalities with variable time-delay. To justify…”
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Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes by Drel, Viktor, Pacher, Pal, Vareniuk, Igor, Pavlov, Ivan, Ilnytska, Olga, Lyzogubov, Valeriy, Bell, Seth, Groves, John, Obrosova, Irina

“…Whereas the important role of free radicals in diabetes-associated complications is well established, the contributions of the highly reactive oxidant…”
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High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity by Obrosova, Irina G., Ilnytska, Olga, Lyzogubov, Valeriy V., Pavlov, Ivan A., Mashtalir, Nazar, Nadler, Jerry L., Drel, Viktor R.

“…High-Fat Diet–Induced Neuropathy of Pre-Diabetes and Obesity Effects of “Healthy” Diet and Aldose Reductase Inhibition Irina G. Obrosova 1 , Olga Ilnytska 1 ,…”
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The Leptin-Deficient (ob/ob) Mouse by Drel, Viktor R., Mashtalir, Nazar, Ilnytska, Olga, Shin, Jeho, Li, Fei, Lyzogubov, Valeriy V., Obrosova, Irina G.

“…The Leptin-Deficient ( ob/ob ) Mouse A New Animal Model of Peripheral Neuropathy of Type 2 Diabetes and Obesity Viktor R. Drel , Nazar Mashtalir , Olga…”
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Lysobisphosphatidic acid (LBPA) enrichment promotes cholesterol egress via exosomes in Niemann Pick type C1 deficient cells by Ilnytska, Olga, Jeziorek, Maciej, Lai, Kimberly, Altan-Bonnet, Nihal, Dobrowolski, Radek, Storch, Judith

“…•Phosphatidylglycerol (PG) incubation of NPC1 disease cells raises lysobisphosphatidic acid (LBPA) and reduces endolysosomal cholesterol.•Marked enrichment of…”
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Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy by Obrosova, Irina G., Drel, Viktor R., Pacher, Pal, Ilnytska, Olga, Wang, Zhong Q., Stevens, Martin J., Yorek, Mark A.

“…Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy The Relation Is Revisited Irina G. Obrosova…”
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Structure-function relationships of cholesterol mobilization from the endo-lysosome compartment of NPC1-deficient human cells by [beta]-CD polyrotaxanes by Samaddar, Shayak, Bose, Debosreeta, Loren, Bradley P, Skulsky, Joseph L, Ilnytska, Olga, Struzik, Zachary J, Storch, Judith, Thompson, David H

“…Niemann-Pick Type C is a rare metabolic disorder characterized by the cellular accumulation of cholesterol within endosomal and lysosomal compartments…”
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Role of Autophagy in Phosphatidyl- Glycerol Facilitated Cholesterol Clearance from the Endolysosomal System of Npc-1 Deficient Cells by Allada, Tamara, Ilnytska, Olga, Storch, Judith

“…Niemann Pick Type C (NPC) Disease is a rare lysosomal storage disorder in which one of the genes that codes for either the NPC-1 or NPC-2 pro-tein is mutated,…”
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Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage by Ilnytska, Olga, Lai, Kimberly, Gorshkov, Kirill, Schultz, Mark L., Tran, Bruce Nguyen, Jeziorek, Maciej, Kunkel, Thaddeus J., Azaria, Ruth D., McLoughlin, Hayley S., Waghalter, Miriam, Xu, Yang, Schlame, Michael, Altan-Bonnet, Nihal, Zheng, Wei, Lieberman, Andrew P., Dobrowolski, Radek, Storch, Judith

“…Niemann–Pick C (NPC) is an autosomal recessive disorder characterized by mutations in the NPC1 or NPC2 genes encoding endolysosomal lipid transport proteins,…”
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Molecular determinants of phospholipid treatment to reduce intracellular cholesterol accumulation in NPC1 deficiency by Deng, Shikun, Liu, Ting-Ann, Ilnytska, Olga, Allada, Tamara, Fomina, Angelina, Lin, Nancy, Petukhova, Valentina Z., Pathmasiri, Koralege C., Chinthapally, Kiran, Blagg, Brian S.J., Ashfeld, Brandon L., Cologna, Stephanie M., Storch, Judith

“…Niemann-Pick type C (NPC) disease, caused by mutations in the NPC1 or NPC2 genes, leads to abnormal intracellular cholesterol accumulation in late…”
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High-fat diet-induced neuropathy of pre-diabetes and obesity : Effects of healthy diet and aldose reductase inhibition by OBROSOVA, Irina G, ILNYTSKA, Olga, LYZOGUBOV, Valeriy V, PAVLOV, Ivan A, MASHTALIR, Nazar, NADLER, Jerry L, DREL, Viktor R

“…Subjects with dietary obesity and pre-diabetes have an increased risk for developing both nerve conduction slowing and small sensory fiber neuropathy. Animal…”
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The leptin-deficient (ob/ob) mouse : A new animal model of peripheral neuropathy of type 2 diabetes and obesity by DREL, Viktor R, MASHTALIR, Nazar, ILNYTSKA, Olga, SHIN, Jeho, FEI LI, LYZOGUBOV, Valeriy V, OBROSOVA, Irina G

“…Whereas functional, metabolic, neurotrophic, and morphological abnormalities of peripheral diabetic neuropathy (PDN) have been extensively explored in…”
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Differential effects of P2Y 1 and P2Y 12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3‐kinase signalling and cell proliferation in serum‐deprived and nonstarved glioma C6 cells by Czajkowski, Rafał, Banachewicz, Wiktor, Ilnytska, Olga, Drobot, Ludmila B, Barańska, Jolanta

“…We have previously shown that, in glioma C6 cells, two nucleotide ADP‐sensitive receptors coexist: P2Y 1 , coupled to PLC and responsible for Ca 2+ release,…”
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Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy : The relation is revisited by OBROSOVA, Irina G, DREL, Viktor R, PACHER, Pal, ILNYTSKA, Olga, WANG, Zhong Q, STEVENS, Martin J, YOREK, Mark A

“…Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the pathogenesis of diabetes complications, is considered a downstream effector of…”
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Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient ( ob/ob) mice by Vareniuk, Igor, Pavlov, Ivan A., Drel, Viktor R., Lyzogubov, Valeriy V., Ilnytska, Olga, Bell, Seth R., Tibrewala, Jyoti, Groves, John T., Obrosova, Irina G.

“…Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia, and impaired nitrergic innervation in animal models of Type 1 diabetes. The…”
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