Search Results - "Ilmjarv, Sten"

Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss by Rousset, Francis, Nacher-Soler, German, Coelho, Marta, Ilmjarv, Sten, Kokje, Vivianne Beatrix Christina, Marteyn, Antoine, Cambet, Yves, Perny, Michael, Roccio, Marta, Jaquet, Vincent, Senn, Pascal, Krause, Karl Heinz

“…Age-related hearing (ARHL) loss affects a large part of the human population with a major impact on our aging societies. Yet, underlying mechanisms are not…”
Get full text

Modeling Poliovirus Infection Using Human Engineered Neural Tissue Enriched With Motor Neuron Derived From Embryonic Stem Cells by Cosset, Érika, Hibaoui, Youssef, Ilmjärv, Sten, Dietrich, Pierre-Yves, Tapparel, Caroline, Krause, Karl-Heinz

“…Poliomyelitis is caused by poliovirus (PV), a positive strand non-enveloped virus. Since its discovery in the 1950s, several cell culture and molecular methods…”
Get full text

Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors by Lito, Silvin, Sidibe, Adama, Ilmjarv, Sten, Burda, Patricie, Baumgartner, Matthias, Wehrle-Haller, Bernhard, Krause, Karl-Heinz, Marteyn, Antoine

“…: Mucopolysaccharidosis type I-Hurler (MPS1-H) is a severe genetic lysosomal storage disorder due to loss-of-function mutations in the gene. The subsequent…”
Get full text

Effect of light on global gene expression in the neuroglobin-deficient mouse retina by ILMJÄRV, STEN, REIMETS, RIIN, HUNDAHL, CHRISTIAN ANSGAR, LUUK, HENDRIK

“…Several previous studies have raised controversy over the functional role of neuroglobin (Ngb) in the retina. Certain studies indicate a significant impact of…”
Get full text

Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant by Ilmjärv, Sten, Abdul, Fabien, Acosta-Gutiérrez, Silvia, Estarellas, Carolina, Galdadas, Ioannis, Casimir, Marina, Alessandrini, Marco, Gervasio, Francesco Luigi, Krause, Karl-Heinz

“…The D614G mutation in the Spike protein of the SARS-CoV-2 has effectively replaced the early pandemic-causing variant. Using pseudotyped lentivectors, we…”
Get full text

Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma by Cosset, Érika, Ilmjärv, Sten, Dutoit, Valérie, Elliott, Kathryn, von Schalscha, Tami, Camargo, Maria F., Reiss, Alexander, Moroishi, Toshiro, Seguin, Laetitia, Gomez, German, Moo, Jung-Soon, Preynat-Seauve, Olivier, Krause, Karl-Heinz, Chneiweiss, Hervé, Sarkaria, Jann N., Guan, Kun-Liang, Dietrich, Pierre-Yves, Weis, Sara M., Mischel, Paul S., Cheresh, David A.

“…While molecular subtypes of glioblastoma (GBM) are defined using gene expression and mutation profiles, we identify a unique subpopulation based on addiction…”
Get full text

Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells by Seguin, Laetitia, Odouard, Soline, Corlazzoli, Francesca, Haddad, Sarah Al, Moindrot, Laurine, Calvo Tardón, Marta, Yebra, Mayra, Koval, Alexey, Marinari, Eliana, Bes, Viviane, Guérin, Alexandre, Allard, Mathilde, Ilmjärv, Sten, Katanaev, Vladimir L., Walker, Paul R., Krause, Karl-Heinz, Dutoit, Valérie, Sarkaria, Jann N., Dietrich, Pierre-Yves, Cosset, Érika

“…Recently, we involved the carbohydrate-binding protein Galectin-3 (Gal-3) as a druggable target for KRAS-mutant-addicted lung and pancreatic cancers. Here,…”
Get full text

Melanocytes in the skin--comparative whole transcriptome analysis of main skin cell types by Reemann, Paula, Reimann, Ene, Ilmjärv, Sten, Porosaar, Orm, Silm, Helgi, Jaks, Viljar, Vasar, Eero, Kingo, Külli, Kõks, Sulev

“…Melanocytes possess several functions besides a role in pigment synthesis, but detailed characteristics of the cells are still unclear. We used whole…”
Get full text

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay by Colaianna, Marilena, Ilmjärv, Sten, Peterson, Hedi, Kern, Ilse, Julien, Stephanie, Baquié, Mathurin, Pallocca, Giorgia, Bosgra, Sieto, Sachinidis, Agapios, Hengstler, Jan G., Leist, Marcel, Krause, Karl-Heinz

“…Identification of neurotoxic drugs and environmental chemicals is an important challenge. However, only few tools to address this topic are available. The aim…”
Get full text

A label-retaining but unipotent cell population resides in biliary compartment of mammalian liver by Viil, Janeli, Klaas, Mariliis, Valter, Kadri, Belitškin, Denis, Ilmjärv, Sten, Jaks, Viljar

“…Cells with slow proliferation kinetics that retain the nuclear label over long time periods–the label-retaining cells (LRCs)–represent multipotent stem cells…”
Get full text

Navigating in vitro bioactivity data by investigating available resources using model compounds by Ilmjärv, Sten, Augsburger, Fiona, Bolleman, Jerven Tjalling, Liechti, Robin, Bridge, Alan James, Sandström, Jenny, Jaquet, Vincent, Xenarios, Ioannis, Krause, Karl-Heinz

“…The number of chemical compounds and associated experimental data in public databases is growing, but presently there is no simple way to access these data in…”
Get full text

Intrinsically Self-renewing Neuroprogenitors From the A/J Mouse Spiral Ganglion as Virtually Unlimited Source of Mature Auditory Neurons by Rousset, Francis, B C Kokje, Vivianne, Sipione, Rebecca, Schmidbauer, Dominik, Nacher-Soler, German, Ilmjärv, Sten, Coelho, Marta, Fink, Stefan, Voruz, François, El Chemaly, Antoun, Marteyn, Antoine, Löwenheim, Hubert, Krause, Karl-Heinz, Müller, Marcus, Glückert, Rudolf, Senn, Pascal

“…Nearly 460 million individuals are affected by sensorineural hearing loss (SNHL), one of the most common human sensory disorders. In mammals, hearing loss is…”
Get full text

Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo by Hundahl, Christian Ansgar, Luuk, Hendrik, Ilmjärv, Sten, Falktoft, Birgitte, Raida, Zindy, Vikesaa, Jonas, Friis-Hansen, Lennart, Hay-Schmidt, Anders

“…Neuroglobin (Ngb), a neuron-specific globin that binds oxygen in vitro, has been proposed to play a key role in neuronal survival following hypoxic and…”
Get full text

Correction: Melanocytes in the Skin - Comparative Whole Transcriptome Analysis of Main Skin Cell Types by Reemann, Paula, Reimann, Ene, Ilmjärv, Sten, Porosaar, Orm, Silm, Helgi, Jaks, Viljar, Vasar, Eero, Kingo, Külli, Kõks, Sulev

“…[This corrects the article DOI: 10.1371/journal.pone.0115717.]…”
Get full text

Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing by Kuegler, Philipp B, Zimmer, Bastian, Waldmann, Tanja, Baudis, Birte, Ilmjärv, Sten, Hescheler, Jürgen, Gaughwin, Phil, Brundin, Patrik, Mundy, William, Bal-Price, Anna K, Schrattenholz, André, Krause, Karl-Heinz, van Thriel, Christoph, Rao, Mahendra S, Kadereit, Suzanne, Leist, Marcel

“…Developmental neurotoxicity (DNT) is a serious concern for environmental chemicals, as well as for food and drug constituents. Animal-based DNT models have…”
Get more information

Hyaline Cartilage Microtissues Engineered from Adult Dedifferentiated Chondrocytes: Safety and Role of WNT Signaling by Kutaish, Halah, Bengtsson, Laura, Matthias Tscholl, Philippe, Marteyn, Antoine, Braunersreuther, Vincent, Guérin, Alexandre, Béna, Frédérique, Gimelli, Stefania, Longet, David, Ilmjärv, Sten, Dietrich, Pierre-Yves, Gerstel, Eric, Jaquet, Vincent, Hannouche, Didier, Menetrey, Jacques, Assal, Mathieu, Krause, Karl-Heinz, Cosset, Erika, Tieng, Vannary

“…The repair of damaged articular cartilage is an unmet medical need. Chondrocyte-based cell therapy has been used to repair cartilage for over 20 years despite…”
Get full text

Estimating differential expression from multiple indicators by Ilmjärv, Sten, Hundahl, Christian Ansgar, Reimets, Riin, Niitsoo, Margus, Kolde, Raivo, Vilo, Jaak, Vasar, Eero, Luuk, Hendrik

“…Regardless of the advent of high-throughput sequencing, microarrays remain central in current biomedical research. Conventional microarray analysis pipelines…”
Get full text

Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing by Kuegler, Philipp

Get full text