Search Results - "Illingworth, D.Roger"

Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia by Raal, Frederick J., Pappu, Anuradha S., Illingworth, D.Roger, Pilcher, Gillian J., Marais, A.David, Firth, Jean C., Kotze, Maritha J., Heinonen, Therese M., Black, Donald M.

“…Patients with homozygous familial hypercholesterolaemia (HoFH) have markedly elevated low density lipoprotein (LDL) cholesterol levels that are refractory to…”
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The Efficacy and Six-Week Tolerability of Simvastatin 80 and 160 mg/Day by Davidson, Michael H., Stein, Evan A., Dujovne, Carlos A., Hunninghake, Donald B., Weiss, Stuart R., Knopp, Robert H., Illingworth, D.Roger, Mitchel, Yale B., Melino, Michael R., Zupkis, Robert V., Dobrinska, Michael R., Amin, Raju D., Tobert, Jonathan A.

“…The hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin is the most effective of the currently approved hypolipidemic drugs and has been shown to…”
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Expanded-dose simvastatin is effective in homozygous familial hypercholesterolaemia by Raal, Frederick J, Pilcher, Gillian J, Illingworth, D.Roger, Pappu, Anuradha S, Stein, Evan A, Laskarzewski, Peter, Mitchel, Yale B, Melino, Michael R

“…Patients with homozygous familial hypercholesterolaemia (HFH) have abnormalities in both low-density lipoprotein (LDL) receptor alleles, resulting in severe…”
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Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion by Pappu, Anuradha S, Steiner, Robert D, Connor, Sonja L, Flavell, Donna P, Lin, Don S, Hatcher, Lauren, Illingworth, D Roger, Connor, William E

“…Smith-Lemli-Opitz syndrome (SLOS) is a genetic disorder characterized by low plasma cholesterol and high 7-dehydrocholesterol (7-DHC). Synthesis of cholesterol…”
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How effective is drug therapy in heterozygous familial hypercholesterolemia? by Illingworth, D.Roger

“…The goals of drug therapy in adult patients with heterozygous familial hypercholesterolemia (FH) are directed at reducing plasma concentrations of low density…”
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Treatment of refractory familial hypercholesterolemia by low-density lipoprotein apheresis using an automated dextran sulfate cellulose adsorption system by Gordon, Bruce R., Kelsey, Sheryl F., Bilheimer, David W., Brown, David C., Dau, Peter C., Gotto, Antonio M., Illingworth, D.Roger, Jones, Peter H., Leitman, Susan F., Prihoda, James S., Stein, Evan A., Stern, Thomas N., Zavoral, James H., Zwiener, Robert J.

“…A subgroup of patients with familial hypercholesterolemia (FH) respond inadequately to standard diet and drug therapy, and are therefore at high risk for the…”
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Indications for low-density lipoprotein apheresis by Gordon, Bruce R., Stein, Evan, Jones, Peter, Illingworth, D.Roger

“…Low-density lipoprotein (LDL) apheresis offers an additional approach to lipid lowering in patients with severe hypercholesterolemia who fail to respond…”
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Postprandial dyslipidemia: an atherogenic disorder common in patients with diabetes mellitus by Ginsberg, Henry N, Illingworth, D.Roger

“…The increased risk of coronary artery disease among patients with diabetes mellitus is attributable, in part, to specific disorders of lipoprotein metabolism…”
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Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function by Jenkins, David J.A., Kendall, Cyril W.C., Popovich, David G., Vidgen, Edward, Mehling, Christine C., Vuksan, Vladimir, Ransom, Thomas P.P., Rao, A.Venket, Rosenberg-Zand, Rachel, Tariq, Nauman, Corey, Paul, Jones, Peter J.H., Raeini, Mahmoud, Story, Jon A., Furumoto, Emily J., Illingworth, D.Roger, Pappu, Anuradha S., Connelly, Philip W.

“…We tested the effects of feeding a diet very high in fiber from fruit and vegetables. The levels fed were those, which had originally inspired the dietary…”
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Rhabdomyolysis After Taking Atorvastatin With Gemfibrozil by Duell, P.Barton, Connor, William E, Illingworth, D.Roger

“…The findings in this case indicate that atorvastatin, like other DL-3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, may increase the risk of…”
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Achievement of low-density lipoprotein cholesterol goals: new strategies to address new guidelines by Illingworth, D Roger

“…Evidence that CHD morbidity and mortality can be reduced with reduction of LDL-C to less than 100 mg/dL (2.6 mmol/L) is rapidly accumulating. NCEP-ATP III…”
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Long-Term Effects of Low-Density Lipoprotein Apheresis Using an Automated Dextran Sulfate Cellulose Adsorption System by Gordon, Bruce R., Kelsey, Sheryl F., Dau, Peter C., Gotto, Antonio M., Graham, Kevin, Illingworth, D.Roger, Isaacsohn, Jonathan, Jones, Peter H., Leitman, Susan F., Saal, Stuart D., Stein, Evan A., Stern, Thomas N., Troendle, August, Zwiener, Robert J.

“…The short-term effectiveness of low-density lipoprotein (LDL) apheresis using a dextran sulfate cellulose adsorption column technique was previously examined…”
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The effects of lovastatin and simvastatin on the diurnal periodicity of plasma mevalonate concentrations in patients with heterozygous familial hypercholesterolemia by Pappu, Anuradha S, Illingworth, D.Roger

“…Animal and human studies have shown that the biosynthesis of cholesterol exhibits diurnal periodicity with nocturnal increases in the level of cholesterol…”
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New risk factors for coronary heart disease by Illingworth, D R

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The influence of apolipoprotein E phenotype on the response to lovastatin therapy in patients with heterozygous familial hypercholesterolemia by O'Malley, J P, Illingworth, D R

“…Apolipoprotein E (apo E) phenotypes have been previously shown to influence plasma lipoprotein concentrations in normal populations and to affect the response…”
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Hypolipidemic effects of HMG-CoA reductase inhibitors in patients with hypercholesterolemia by Illingworth, D.Roger, Bacon, Sandra

“…Hypercholesterolemia with increased plasma concentrations of low density lipoproteins (LDL) is a major risk factor for the premature development of coronary…”
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The hypolipidemic effects of lovastatin and clofibrate alone and in combination in patients with type III hyperlipoproteinemia by Illingworth, D R, O'Malley, J P

“…The hypolipidemic effects of lovastatin and clofibrate have been evaluated in 12 patients with type III hyperlipoproteinemia. In these patients plasma…”
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Long-Term Effects of Low-Density Lipoprotein Apheresis Using an Automated Dextran Sulfate Cellulose Adsorption System fn1fn1This study was supported by a grant from the Kaneka America Corporation, New York, New York by Gordon, Bruce R., Kelsey, Sheryl F., Dau, Peter C., Gotto, Antonio M., Graham, Kevin, Illingworth, D.Roger, Isaacsohn, Jonathan, Jones, Peter H., Leitman, Susan F., Saal, Stuart D., Stein, Evan A., Stern, Thomas N., Troendle, August, Zwiener, Robert J.

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Comparative hypolipidemic effects of lovastatin and simvastatin in patients with heterozygous familial hypercholesterolemia by Illingworth, D R, Bacon, S, Pappu, A S, Sexton, G J

“…We have compared the effects of lovastatin and simvastatin on plasma lipoproteins, fibrinogen and urinary mevalonic acid excretion in twenty-three patients…”
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Comparative effects of gemfibrozil and clofibrate in type III hyperlipoproteinemia by Larsen, M L, Illingworth, D R, O'Malley, J P

“…Type III hyperlipoproteinemia (dysbetalipoproteinemia) is characterized by elevated concentrations of plasma cholesterol and triglycerides due to an increase…”
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