Search Results - "Iliopoulos, Dimitrios"

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth by Hirsch, Heather A., Iliopoulos, Dimitrios, Struhl, Kevin

“…Metformin, the first-line drug for treating diabetes, inhibits cellular transformation and selectively kills cancer stem cells in breast cancer cell lines. In…”
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Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types by ILIOPOULOS, Dimitrios, HIRSCH, Heather A, STRUHL, Kevin

“…Metformin, the first-line drug for treating diabetes, selectively kills the chemotherapy resistant subpopulation of cancer stem cells (CSC) in genetically…”
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COVID‐19: A Greek Perspective by Iliopoulos, Dimitrios C.

“…Greece has managed to timely and properly implement a public health safety plan and contained the burden of the coronavirus disease (COVID‐19) pandemic. On the…”
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Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion by Iliopoulos, Dimitrios, Hirsch, Heather A., Wang, Guannan, Struhl, Kevin

“…Tumors are often heterogeneous, being composed of multiple cell types with different phenotypic and molecular properties. Cancer stem-like cells (CSCs) are a…”
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STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer by Iliopoulos, Dimitrios, Jaeger, Savina A., Hirsch, Heather A., Bulyk, Martha L., Struhl, Kevin

“…A transient inflammatory signal can initiate an epigenetic switch from nontransformed to cancer cells via a positive feedback loop involving NF-κB, Lin28,…”
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Inflammatory Bowel Disease Therapy: Beyond the Immunome by Fiocchi, Claudio, Iliopoulos, Dimitrios

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An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state by Polytarchou, Christos, Iliopoulos, Dimitrios, Struhl, Kevin

“…Cancer stem-like cells (CSCs) are a highly tumorigenic cell type present as a minority population in developmentally diverse tumors and cell lines. Using a…”
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Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks by Iliopoulos, Dimitrios, Malizos, Konstantinos N, Oikonomou, Pagona, Tsezou, Aspasia

“…Osteoarthritis is a multifactorial disease characterized by destruction of the articular cartilage due to genetic, mechanical and environmental components…”
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Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms by Piskounova, Elena, Polytarchou, Christos, Thornton, James E., LaPierre, Robert J., Pothoulakis, Charalabos, Hagan, John P., Iliopoulos, Dimitrios, Gregory, Richard I.

“…Lin28A and Lin28B selectively block the expression of let-7 microRNAs and function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase…”
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Association of postoperative fluid overload with adverse outcomes after congenital heart surgery: a systematic review and dose-response meta-analysis by Bellos, Ioannis, Iliopoulos, Dimitrios C., Perrea, Despina N.

“…Background Pediatric cardiac surgery is commonly associated with acute kidney injury (AKI) and significant fluid retention, which complicate postoperative…”
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Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells by Iliopoulos, Dimitrios, Lindahl-Allen, Marianne, Polytarchou, Christos, Hirsch, Heather A., Tsichlis, Philip N., Struhl, Kevin

“…In an inducible oncogenesis model, the miR-200 family is inhibited during CSC formation but not transformation, and inhibition of miR-200b increases CSC…”
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Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling by He, Guobin, Dhar, Debanjan, Nakagawa, Hayato, Font-Burgada, Joan, Ogata, Hisanobu, Jiang, Yuhong, Shalapour, Shabnam, Seki, Ekihiro, Yost, Shawn E., Jepsen, Kristen, Frazer, Kelly A., Harismendy, Olivier, Hatziapostolou, Maria, Iliopoulos, Dimitrios, Suetsugu, Atsushi, Hoffman, Robert M., Tateishi, Ryosuke, Koike, Kazuhiko, Karin, Michael

“…Hepatocellular carcinoma (HCC) is a slowly developing malignancy postulated to evolve from premalignant lesions in chronically damaged livers. However, it was…”
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MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism[S] by Iliopoulos, Dimitrios, Drosatos, Konstantinos, Hiyama, Yaeko, Goldberg, Ira J., Zannis, Vassilis I.

“…We previously observed that treatment of mice with a dominant negative form of cJun (dn-cJun) increased the expression of genes involved in lipid metabolism…”
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A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation by Padua, David, Mahurkar-Joshi, Swapna, Law, Ivy Ka Man, Polytarchou, Christos, Vu, John P, Pisegna, Joseph R, Shih, David, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

“…High-throughput technologies revealed new categories of genes, including the long noncoding RNAs (lncRNAs), involved in the pathogenesis of human disease;…”
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Residual strains in ascending thoracic aortic aneurysms: The effect of valve type, layer, and circumferential quadrant by Sokolis, Dimitrios P., Ch. Markidi, Despoina, Iliopoulos, Dimitrios C., Kourkoulis, Stavros K.

“…The stress distribution in ascending thoracic aortic aneurysms is determined by the mechanical properties, geometry, loading conditions, and zero-stress state…”
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MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells by Bakirtzi, Kyriaki, Man Law, Ivy Ka, Fang, Kai, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

“…Exosomes are cellular vesicles involved in intercellular communication via their specialized molecular cargo, such as miRNAs. Substance P (SP), a…”
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The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs by Androulidaki, Ariadne, Iliopoulos, Dimitrios, Arranz, Alicia, Doxaki, Christina, Schworer, Steffen, Zacharioudaki, Vassiliki, Margioris, Andrew N., Tsichlis, Philip N., Tsatsanis, Christos

“…MicroRNAs regulated by lipopolysaccharide (LPS) target genes that contribute to the inflammatory phenotype. Here, we showed that the protein kinase Akt1, which…”
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The Role of MicroRNA-126 in Atherosclerotic Cardiovascular Diseases by Theofilis, Panagiotis, Oikonomou, Evangelos, Vogiatzi, Georgia, Sagris, Marios, Antonopoulos, Alexios S, Siasos, Gerasimos, Iliopoulos, Dimitrios C, Perrea, Despoina, Vavouranakis, Manolis, Tsioufis, Konstantinos, Tousoulis, Dimitris

“…Atherosclerotic cardiovascular diseases remain the leading cause of morbidity and mortality worldwide despite all efforts made towards their management. Other…”
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Effect of Aneurysm and Bicuspid Aortic Valve on Layer-Specific Ascending Aorta Mechanics by Deveja, Rezar P., Iliopoulos, Dimitrios C., Kritharis, Eleftherios P., Angouras, Dimitrios C., Sfyris, Dimitrios, Papadodima, Stavroula A., Sokolis, Dimitrios P.

“…Previous studies have not examined the participation of intimal, medial, and adventitial layers in providing mechanical strength to the ascending thoracic…”
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Neurotensin Signaling Activates MicroRNAs-21 and -155 and Akt, Promotes Tumor Growth in Mice, and Is Increased in Human Colon Tumors by Bakirtzi, Kyriaki, Hatziapostolou, Maria, Karagiannides, Iordanes, Polytarchou, Christos, Jaeger, Savina, Iliopoulos, Dimitrios, Pothoulakis, Charalabos

“…Background & Aims Neurotensin promotes inflammation and colon cancer via the neurotensin-1 receptor (NTR1). MicroRNAs (miR) regulate protein synthesis by…”
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