Search Results - "Ilina, Tatiana V."

Large Multidomain Protein NMR: HIV-1 Reverse Transcriptase Precursor in Solution by Ilina, Tatiana V, Xi, Zhaoyong, Brosenitsch, Teresa, Sluis-Cremer, Nicolas, Ishima, Rieko

“…NMR studies of large proteins, over 100 kDa, in solution are technically challenging and, therefore, of considerable interest in the biophysics field. The…”
Get full text

Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate by Sun, Zehua, Chu, Xiaojie, Adams, Cynthia, Ilina, Tatiana V., Guerrero, Michel, Lin, Guowu, Chen, Chuan, Jelev, Dontcho, Ishima, Rieko, Li, Wei, Mellors, John W., Calero, Guillermo, Dimitrov, Dimiter S.

“…Mesothelin (MSLN) has been a validated tumor-associated antigen target for several solid tumors for over a decade, making it an attractive option for…”
Get full text

Effect of Lysyl–tRNA Synthetase on the Maturation of HIV‑1 Reverse Transcriptase by Ilina, Tatiana V, Slack, Ryan L, Guerrero, Michel, Ishima, Rieko

“…In human immunodeficiency virus-1 (HIV-1), reverse transcriptase (RT) is encoded as a 66 kDa protein, p66, in the Gag-Pol polyprotein. This protein is…”
Get full text

Interplay between protease and reverse transcriptase dimerization in a model HIV‐1 polyprotein by Chagas, Brisa Caroline Alves, Zhou, Xiaohong, Guerrero, Michel, Ilina, Tatiana V., Ishima, Rieko

“…The Gag‐Pol polyprotein in human immunodeficiency virus type I (HIV‐1) encodes enzymes that are essential for virus replication: protease (PR), reverse…”
Get full text

The HIV-1 protein Nef activates the Tec family kinase Btk by stabilizing an intermolecular SH3-SH2 domain interaction by Aryal, Manish, Lin, David, Regan, Kiera, Du, Shoucheng, Shi, Haibin, Alvarado, John J, Ilina, Tatiana V, Andreotti, Amy H, Smithgall, Thomas E

“…The Nef protein produced by the viruses HIV-1 and SIV drives efficient viral replication partially by inducing constitutive activation of host cell tyrosine…”
Get more information

A synergy of activity, stability, and inhibitor‐interaction of HIV‐1 protease mutants evolved under drug‐pressure by Khan, Shahid N., Persons, John D., Guerrero, Michel, Ilina, Tatiana V., Oda, Masayuki, Ishima, Rieko

“…A clinically‐relevant, drug‐resistant mutant of HIV‐1 protease (PR), termed Flap+(I54V) and containing L10I, G48V, I54V and V82A mutations, is known to produce…”
Get full text

Relative domain orientation of the L289K HIV‐1 reverse transcriptase monomer by Xi, Zhaoyong, Ilina, Tatiana V., Guerrero, Michel, Fan, Lixin, Sluis‐Cremer, Nicolas, Wang, Yun‐Xing, Ishima, Rieko

“…HIV‐1 reverse transcriptase (RT) is a heterodimer comprised p66 and p51 subunits (p66/p51). Several single amino acid substitutions in RT, including L289K,…”
Get full text

Development of Human Immunodeficiency Virus Type 1 Resistance to 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine Starting with Wild-Type or Nucleoside Reverse Transcriptase Inhibitor-Resistant Strains by Cilento, Maria E, Reeve, Aaron B, Michailidis, Eleftherios, Ilina, Tatiana V, Nagy, Eva, Mitsuya, Hiroaki, Parniak, Michael A, Tedbury, Philip R, Sarafianos, Stefan G

“…4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA, MK-8591, islatravir) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with exceptional…”
Get full text

The reduced form of the antibody CH2 domain by Xi, Zhaoyong, Liu, Xianglei, Lin, Rui, Persons, John D., Ilina, Tatiana V., Li, Wei, Dimitrov, Dimiter S., Ishima, Rieko

“…Among the immunoglobulin domains, the CH2 domain has the lowest thermal stability, which also depends on amino acid sequence and buffer conditions. To further…”
Get full text

Effect of tRNA on the Maturation of HIV-1 Reverse Transcriptase by Ilina, Tatiana V., Slack, Ryan L., Elder, John H., Sarafianos, Stefan G., Parniak, Michael A., Ishima, Rieko

“…The mature HIV-1 reverse transcriptase is a heterodimer that comprises 66 kDa (p66) and 51 kDa (p51) subunits. The latter is formed by HIV-1 protease-catalyzed…”
Get full text

Retroviral RNase H: Structure, mechanism, and inhibition by Ilina, Tatiana V, Brosenitsch, Teresa, Sluis-Cremer, Nicolas, Ishima, Rieko

“…All retroviruses encode the enzyme, reverse transcriptase (RT), which is involved in the conversion of the single-stranded viral RNA genome into…”
Get full text

Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation by Slack, Ryan L., Ilina, Tatiana V., Xi, Zhaoyong, Giacobbi, Nicholas S., Kawai, Gota, Parniak, Michael A., Sarafianos, Stefan G., Sluis Cremer, Nicolas, Ishima, Rieko

“…HIV-1 reverse transcriptase (RT) is translated as part of the Gag-Pol polyprotein that is proteolytically processed by HIV-1 protease (PR) to finally become a…”
Get full text

Inhibitors of HIV‑1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV‑1 Replication in Macrophages and Disrupt MHC‑I Downregulation by Emert-Sedlak, Lori A, Moukha-Chafiq, Omar, Shi, Haibin, Du, Shoucheng, Alvarado, John J, Pathak, Vibha, Tanner, Samuel G, Hunter, Robert N, Nebane, Miranda, Chen, Li, Ilina, Tatiana V, Ishima, Rieko, Zhang, Sixue, Kuzmichev, Yury V, Wonderlich, Elizabeth R, Schader, Susan M, Augelli-Szafran, Corinne E, Ptak, Roger G, Smithgall, Thomas E

“…HIV-1 Nef is an attractive target for antiretroviral drug discovery because of its role in promoting HIV-1 infectivity, replication, and host immune system…”
Get full text

Effect of tRNA on the maturation of HIV-reverse transcriptase by Ilina, Tatiana V., Slack, Ryan L., Elder, John H., Sarafianos, Stefan G., Parniak, Michael A., Ishima, Rieko

“…The mature HIV-1 reverse transcriptase is a heterodimer that comprises 66 kDa (p66) and 51 kDa (p51) subunits. The latter is formed by HIV-1 protease-catalyzed…”
Get full text