Search Results - "Ilina, Ekaterina S."

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors by Filimonov, Aleksander S, Chepanova, Arina A, Luzina, Olga A, Zakharenko, Alexandra L, Zakharova, Olga D, Ilina, Ekaterina S, Dyrkheeva, Nadezhda S, Kuprushkin, Maxim S, Kolotaev, Anton V, Khachatryan, Derenik S, Patel, Jinal, Leung, Ivanhoe K H, Chand, Raina, Ayine-Tora, Daniel M, Reynisson, Johannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can…”
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Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1 by Il'ina, Irina V, Dyrkheeva, Nadezhda S, Zakharenko, Alexandra L, Sidorenko, Alexander Yu, Li-Zhulanov, Nikolay S, Korchagina, Dina V, Chand, Raina, Ayine-Tora, Daniel M, Chepanova, Arina A, Zakharova, Olga D, Ilina, Ekaterina S, Reynisson, Jóhannes, Malakhova, Anastasia A, Medvedev, Sergey P, Zakian, Suren M, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Two novel structural types of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors with hexahydroisobenzofuran and 3-oxabicyclo [3.3.1]nonane scaffolds were…”
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Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy by Khomenko, Tatyana M, Zakharenko, Alexandra L, Chepanova, Arina A, Ilina, Ekaterina S, Zakharova, Olga D, Kaledin, Vasily I, Nikolin, Valeriy P, Popova, Nelly A, Korchagina, Dina V, Reynisson, Jóhannes, Chand, Raina, Ayine-Tora, Daniel M, Patel, Jinal, Leung, Ivanhoe K H, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new…”
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The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo by Chernyshova, Irina A, Zakharenko, Aleksandra L, Kurochkin, Nikolay N, Dyrkheeva, Nadezhda S, Kornienko, Tatyana E, Popova, Nelly A, Nikolin, Valeriy P, Ilina, Ekaterina S, Zharkov, Timofey D, Kupryushkin, Maxim S, Oslovsky, Vladimir E, Drenichev, Mikhail S, Lavrik, Olga I

“…The use of cancer chemotherapy sensitizers is a promising approach to induce the effect of clinically used anticancer treatments. One of the interesting…”
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Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments by Munkuev, Aldar A., Mozhaitsev, Evgenii S., Chepanova, Arina A., Suslov, Evgeniy V., Korchagina, Dina V., Zakharova, Olga D., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Zakharenko, Alexandra L., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison,…”
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Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors by Gladkova, Elizaveta D, Chepanova, Arina A, Ilina, Ekaterina S, Zakharenko, Alexandra L, Reynisson, Jóhannes, Luzina, Olga A, Volcho, Konstantin P, Lavrik, Olga I, Salakhutdinov, Nariman F

“…A new type of berberine derivatives was obtained by the reaction of berberrubine with aliphatic sulfonyl chlorides. The new polycyclic compounds have a sultone…”
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New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2 by Salomatina, Oksana V, Dyrkheeva, Nadezhda S, Popadyuk, Irina I, Zakharenko, Alexandra L, Ilina, Ekaterina S, Komarova, Nina I, Reynisson, Jóhannes, Salakhutdinov, Nariman F, Lavrik, Olga I, Volcho, Konstantin P

“…A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and…”
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New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1 by Dyrkheeva, Nadezhda S, Filimonov, Aleksandr S, Luzina, Olga A, Orlova, Kristina A, Chernyshova, Irina A, Kornienko, Tatyana E, Malakhova, Anastasia A, Medvedev, Sergey P, Zakharenko, Alexandra L, Ilina, Ekaterina S, Anarbaev, Rashid O, Naumenko, Konstantin N, Klabenkova, Kristina V, Burakova, Ekaterina A, Stetsenko, Dmitry A, Zakian, Suren M, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (TDP1) catalyzes the cleavage of the phosphodiester bond between the tyrosine residue of topoisomerase 1 (TOP1) and the 3'…”
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Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides by Zakharenko, Alexandra L, Drenichev, Mikhail S, Dyrkheeva, Nadezhda S, Ivanov, Georgy A, Oslovsky, Vladimir E, Ilina, Ekaterina S, Chernyshova, Irina A, Lavrik, Olga I, Mikhailov, Sergey N

“…Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives…”
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The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme by Gladkova, Elizaveta D, Nechepurenko, Ivan V, Bredikhin, Roman A, Chepanova, Arina A, Zakharenko, Alexandra L, Luzina, Olga A, Ilina, Ekaterina S, Dyrkheeva, Nadezhda S, Mamontova, Evgeniya M, Anarbaev, Rashid O, Reynisson, Jóhannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…A series of berberine and tetrahydroberberine sulfonate derivatives were prepared and tested against the tyrosyl-DNA phosphodiesterase 1 (Tdp1) DNA-repair…”
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Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan by Munkuev, Aldar A, Dyrkheeva, Nadezhda S, Kornienko, Tatyana E, Ilina, Ekaterina S, Ivankin, Dmitry I, Suslov, Evgeniy V, Korchagina, Dina V, Gatilov, Yuriy V, Zakharenko, Alexandra L, Malakhova, Anastasia A, Reynisson, Jóhannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove…”
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New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition by Dyrkheeva, Nadezhda S., Filimonov, Aleksandr S., Luzina, Olga A., Zakharenko, Alexandra L., Ilina, Ekaterina S., Malakhova, Anastasia A., Medvedev, Sergey P., Reynisson, Jóhannes, Volcho, Konstantin P., Zakian, Suren M., Salakhutdinov, Nariman F., Lavrik, Olga I.

“…Usnic acid (UA) is a secondary metabolite of lichens that exhibits a wide range of biological activities. Previously, we found that UA derivatives are…”
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Poly(ADP-ribosyl)ation and DNA repair synthesis in the extracts of naked mole rat, mouse, and human cells by Kosova, Anastasiya A, Kutuzov, Mikhail M, Evdokimov, Alexei N, Ilina, Ekaterina S, Belousova, Ekaterina A, Romanenko, Svetlana A, Trifonov, Vladimir A, Khodyreva, Svetlana N, Lavrik, Olga I

“…DNA repair capacity in cells of naked mole rat (Hgl), a species known for its longevity and resistance to cancer, is still poorly characterized. Here, using…”
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A Knockout of Poly(ADP-Ribose) Polymerase 1 in a Human Cell Line: An Influence on Base Excision Repair Reactions in Cellular Extracts by Khodyreva, Svetlana N, Ilina, Ekaterina S, Dyrkheeva, Nadezhda S, Kochetkova, Alina S, Yamskikh, Alexandra A, Maltseva, Ekaterina A, Malakhova, Anastasia A, Medvedev, Sergey P, Zakian, Suren M, Lavrik, Olga I

“…Base excision repair (BER) is the predominant pathway for the removal of most forms of hydrolytic, oxidative, and alkylative DNA lesions. The precise…”
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Unusual interaction of human apurinic/apyrimidinic endonuclease 1 (APE1) with abasic sites via the Schiff-base-dependent mechanism by Ilina, Ekaterina S., Khodyreva, Svetlana N., Lavrik, Olga I.

“…Clustered apurinic/apyrimidinic (AP) sites are more cytotoxic than isolated AP lesions because double strand breaks (DSB) can be formed during repair of…”
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Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking by Ivankin, Dmitry I., Dyrkheeva, Nadezhda S., Zakharenko, Alexandra L., Ilina, Ekaterina S., Zarkov, Timofey O., Reynisson, Jóhannes, Luzina, Olga A., Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.

“…[Display omitted] Tyrosyl-DNA phosphodiesterase 1(TDP1) is a promising target for a new therapy in oncological disease as an adjunct to topoisomerase 1 (TOP1)…”
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Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1 by Munkuev, Aldar A., Zakharenko, Alexandra L., Kornienko, Tatyana E., Dyrkheeva, Nadezhda S., Ilina, Ekaterina S., Suslov, Evgeniy V., Issa, Fatima, Achara, Chigozie, Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.

“…Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a DNA repair enzyme that can reduce the efficacy of some anticancer drugs targeting topoisomerase 1 (TOP1) making it…”
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Interaction of PARP-2 with AP site containing DNA by Kutuzov, Mikhail M., Khodyreva, Svetlana N., Ilina, Ekaterina S., Sukhanova, Maria V., Amé, Jean-Christophe, Lavrik, Olga I.

“…In eukaryotes the stability of genome is provided by functioning of DNA repair systems. One of the main DNA repair pathways in eukaryotes is the base excision…”
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Interaction of PARP-2 with DNA structures mimicking DNA repair intermediates and consequences on activity of base excision repair proteins by Kutuzov, Mikhail M., Khodyreva, Svetlana N., Amé, Jean-Christophe, Ilina, Ekaterina S., Sukhanova, Maria V., Schreiber, Valérie, Lavrik, Olga I.

“…Poly(ADP-ribosyl)ation is a posttranslational protein modification significant for genomic stability and cell survival in response to DNA damage…”
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Ku antigen interacts with abasic sites by Ilina, Ekaterina S., Lavrik, Olga I., Khodyreva, Svetlana N.

“…One of the most abundant lesions in DNA is the abasic (AP) sites arising spontaneously or as an intermediate in base excision repair. Certain proteins…”
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