Search Results - "Ilik, İbrahim Avşar"

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing by Bergfort, Alexandra, Preußner, Marco, Kuropka, Benno, Ilik, İbrahim Avşar, Hilal, Tarek, Weber, Gert, Freund, Christian, Aktaş, Tuğçe, Heyd, Florian, Wahl, Markus C.

“…The intrinsically unstructured C9ORF78 protein was detected in spliceosomes but its role in splicing is presently unclear. We find that C9ORF78 tightly…”
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DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome by Aktaş, Tuğçe, Avşar Ilık, İbrahim, Maticzka, Daniel, Bhardwaj, Vivek, Pessoa Rodrigues, Cecilia, Mittler, Gerhard, Manke, Thomas, Backofen, Rolf, Akhtar, Asifa

“…In the absence of DHX9, circular RNAs accumulate and transcription and translation are dysregulated—effects that are exacerbated by concomitant depletion of…”
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Nuclear speckles: dynamic hubs of gene expression regulation by Ilık, İbrahim Avşar, Aktaş, Tuğçe

“…Complex, multistep biochemical reactions that routinely take place in our cells require high concentrations of enzymes, substrates, and other structural…”
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SON and SRRM2 are essential for nuclear speckle formation by Ilik, İbrahim Avşar, Malszycki, Michal, Lübke, Anna Katharina, Schade, Claudia, Meierhofer, David, Aktaş, Tuğçe

“…Nuclear speckles (NS) are among the most prominent biomolecular condensates. Despite their prevalence, research on the function of NS is virtually restricted…”
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The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling by Bergfort, Alexandra, Hilal, Tarek, Kuropka, Benno, Ilik, İbrahim Avşar, Weber, Gert, Aktaş, Tuğçe, Freund, Christian, Wahl, Markus C

“…Abstract Biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) and their recycling after splicing require numerous assembly/recycling factors…”
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Autonomous transposons tune their sequences to ensure somatic suppression by Ilık, İbrahim Avşar, Glažar, Petar, Tse, Kevin, Brändl, Björn, Meierhofer, David, Müller, Franz-Josef, Smith, Zachary D., Aktaş, Tuğçe

“…Transposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-messenger RNA synthesis,…”
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Tandem Stem-Loops in roX RNAs Act Together to Mediate X Chromosome Dosage Compensation in Drosophila by Ilik, Ibrahim Avsar, Quinn, Jeffrey J., Georgiev, Plamen, Tavares-Cadete, Filipe, Maticzka, Daniel, Toscano, Sarah, Wan, Yue, Spitale, Robert C., Luscombe, Nicholas, Backofen, Rolf, Chang, Howard Y., Akhtar, Asifa

“…Dosage compensation in Drosophila is an epigenetic phenomenon utilizing proteins and long noncoding RNAs (lncRNAs) for transcriptional upregulation of the male…”
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uvCLAP is a fast and non-radioactive method to identify in vivo targets of RNA-binding proteins by Maticzka, Daniel, Ilik, Ibrahim Avsar, Aktas, Tugce, Backofen, Rolf, Akhtar, Asifa

“…RNA-binding proteins (RBPs) play important and essential roles in eukaryotic gene expression regulating splicing, localization, translation, and stability of…”
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Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules by Estrada Mallarino, Luisa, Engel, Christina, Ilık, İbrahim Avşar, Maticzka, Daniel, Heyl, Florian, Müller, Barbara, Yakulov, Toma A., Dengjel, Jörn, Backofen, Rolf, Akhtar, Asifa, Walz, Gerd

“…Mutations of cilia-associated molecules cause multiple developmental defects that are collectively termed ciliopathies. However, several ciliary proteins,…”
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FLASH: ultra-fast protocol to identify RNA–protein interactions in cells by Ilik, Ibrahim Avsar, Aktas, Tugce, Maticzka, Daniel, Backofen, Rolf, Akhtar, Asifa

“…Abstract Determination of the in vivo binding sites of RNA-binding proteins (RBPs) is paramount to understanding their function and how they affect different…”
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A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila by Ilik, Ibrahim Avsar, Maticzka, Daniel, Georgiev, Plamen, Gutierrez, Noel Marie, Backofen, Rolf, Akhtar, Asifa

“…The X chromosome provides an ideal model system to study the contribution of RNA-protein interactions in epigenetic regulation. In male flies, roX long…”
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