Search Results - "Ilett, Elizabeth J."

Immune-Mediated Antitumor Activity of Reovirus Is Required for Therapy and Is Independent of Direct Viral Oncolysis and Replication by Prestwich, Robin J, Ilett, Elizabeth J, Errington, Fiona, Diaz, Rosa M, Steele, Lynette P, Kottke, Tim, Thompson, Jill, Galivo, Feorillo, Harrington, Kevin J, Pandha, Hardev S, Selby, Peter J, Vile, Richard G, Melcher, Alan A

“…Purpose: Reovirus is a naturally occurring oncolytic virus in clinical trials. Although tumor infection by reovirus can generate adaptive antitumor immunity,…”
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Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity by PRESTWICH, Robin J, ERRINGTON, Fiona, SELBY, Peter J, VILE, Richard G, MELCHER, Alan A, ILETT, Elizabeth J, MORGAN, Ruth S. M, SCOTT, Karen J, KOTTKE, Timothy, THOMPSON, Jill, MORRISON, Ewan E, HARRINGTON, Kevin J, PANDHA, Hardev S

“…Purpose: Early clinical trials are under way exploring the direct oncolytic potential of reovirus. This study addresses whether tumor infection by reovirus is…”
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Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization by LLETT, Elizabeth J, BARCENA, Montserrat, HOEBEN, Rob C, VILE, Richard G, MELCHER, Alan A, ERRINGTON-MAIS, Fiona, GRIFFIN, Stephen, HARRINGTON, Kevin J, PANDHA, Hardev S, COFFEY, Matthew, SELBY, Peter J, LIMPENS, Ronald W. A. L, MOMMAAS, Mieke

“…Dendritic cells (DC) may be the most effective way of delivering oncolytic viruses to patients. Reovirus, a naturally occurring oncolytic virus, is currently…”
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Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche by Müller, Louise M E, Migneco, Gemma, Scott, Gina B, Down, Jenny, King, Sancha, Askar, Basem, Jennings, Victoria, Oyajobi, Babatunde, Scott, Karen, West, Emma, Ralph, Christy, Samson, Adel, Ilett, Elizabeth J, Muthana, Munitta, Coffey, Matt, Melcher, Alan, Parrish, Christopher, Cook, Gordon, Lawson, Michelle, Errington-Mais, Fiona

“…BackgroundMultiple myeloma (MM) remains an incurable disease and oncolytic viruses offer a well-tolerated addition to the therapeutic arsenal. Oncolytic…”
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Delivery of Oncolytic Reovirus by Cell Carriers by Ilett, Elizabeth J

“…Oncolytic virus therapy is a rapidly expanding branch of cancer immunotherapy and represents a genuine opportunity to improve currently available treatment…”
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Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8⁺ T cell trafficking by Taggart, David, Andreou, Tereza, Scott, Karen J., Williams, Jennifer, Rippaus, Nora, Brownlie, Rebecca J., Ilett, Elizabeth J., Salmond, Robert J., Melcher, Alan, Lorger, Mihaela

“…Inhibition of immune checkpoints programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells results in durable antitumor…”
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Antibody-Neutralized Reovirus Is Effective in Oncolytic Virotherapy by Berkeley, Robert A, Steele, Lynette P, Mulder, Aat A, van den Wollenberg, Diana J M, Kottke, Timothy J, Thompson, Jill, Coffey, Matthew, Hoeben, Rob C, Vile, Richard G, Melcher, Alan, Ilett, Elizabeth J

“…Immunotherapy is showing promise for otherwise incurable cancers. Oncolytic viruses (OVs), developed as direct cytotoxic agents, mediate their antitumor…”
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Reciprocal Human Dendritic Cell-Natural Killer Cell Interactions Induce Antitumor Activity Following Tumor Cell Infection by Oncolytic Reovirus by Prestwich, Robin J, Errington, Fiona, Steele, Lynette P, Ilett, Elizabeth J, Morgan, Ruth S. M, Harrington, Kevin J, Pandha, Hardev S, Selby, Peter J, Vile, Richard G, Melcher, Alan A

“…Oncolytic virotherapy may mediate antitumor effects via direct oncolysis or immune-mediated tumor regression. Although the ability of oncolytic viruses to…”
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Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from First-Line Treatment by Evgin, Laura, Huff, Amanda L, Kottke, Timothy, Thompson, Jill, Molan, Amy M, Driscoll, Christopher B, Schuelke, Matthew, Shim, Kevin G, Wongthida, Phonphimon, Ilett, Elizabeth J, Smith, Karen Kaluza, Harris, Reuben S, Coffey, Matt, Pulido, Jose S, Pandha, Hardev, Selby, Peter J, Harrington, Kevin J, Melcher, Alan, Vile, Richard G

“…Antitumor T-cell responses raised by first-line therapies such as chemotherapy, radiation, tumor cell vaccines, and viroimmunotherapy tend to be weak, both…”
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JX-594, a targeted oncolytic poxvirus for the treatment of cancer by Merrick, Alison E, Ilett, Elizabeth J, Melcher, Alan A

“…JX-594 is a replication-competent Wyeth strain vaccinia virus that was genetically modified to inactive the endogenous thymidine kinase gene and to express…”
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Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade by Samson, Adel, Scott, Karen J, Taggart, David, West, Emma J, Wilson, Erica, Nuovo, Gerard J, Thomson, Simon, Corns, Robert, Mathew, Ryan K, Fuller, Martin J, Kottke, Timothy J, Thompson, Jill M, Ilett, Elizabeth J, Cockle, Julia V, van Hille, Philip, Sivakumar, Gnanamurthy, Polson, Euan S, Turnbull, Samantha J, Appleton, Elizabeth S, Migneco, Gemma, Rose, Ailsa S, Coffey, Matthew C, Beirne, Deborah A, Collinson, Fiona J, Ralph, Christy, Alan Anthoney, D, Twelves, Christopher J, Furness, Andrew J, Quezada, Sergio A, Wurdak, Heiko, Errington-Mais, Fiona, Pandha, Hardev, Harrington, Kevin J, Selby, Peter J, Vile, Richard G, Griffin, Stephen D, Stead, Lucy F, Short, Susan C, Melcher, Alan A

“…Immune checkpoint inhibitors, including those targeting programmed cell death protein 1 (PD-1), are reshaping cancer therapeutic strategies. Evidence suggests,…”
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Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8^sup +^ T cell trafficking by Taggart, David, Andreou, Tereza, Scott, Karen J, Williams, Jennifer, Rippaus, Nora, Brownlie, Rebecca J, Ilett, Elizabeth J, Salmond, Robert J, Melcher, Alan, Lorger, Mihaela

“…Inhibition of immune checkpoints programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells results in durable antitumor…”
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Immune-Mediated Antitumor Activity of Reovirus Is Required forTherapy and Is Independent of Direct Viral Oncolysis and Replication by PRESTWICH, Robin J, ILETT, Elizabeth J, SELBY, PeterJ, VILE, Richard G, MELCHER, Alan A, ERRINGTON, Fiona, DIAZ, Rosa M, STEELE, Lynette P, KOTTKE, Tim, THOMPSON, Jill, GALIVO, Feorillo, HARRINGTON, Kevin J, PANDHA, Hardev S

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