Search Results - "Ileperuma, Sandaru M"

Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers by Neupane, Krishna, Zhao, Meng, Lyons, Aaron, Munshi, Sneha, Ileperuma, Sandaru M., Ritchie, Dustin B., Hoffer, Noel Q., Narayan, Abhishek, Woodside, Michael T.

“…The RNA pseudoknot that stimulates programmed ribosomal frameshifting in SARS-CoV-2 is a possible drug target. To understand how it responds to mechanical…”
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Identifying Inhibitors of -1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses by Munshi, Sneha, Neupane, Krishna, Ileperuma, Sandaru M, Halma, Matthew T J, Kelly, Jamie A, Halpern, Clarissa F, Dinman, Jonathan D, Loerch, Sarah, Woodside, Michael T

“…Recurrent outbreaks of novel zoonotic coronavirus (CoV) diseases in recent years have highlighted the importance of developing therapeutics with broad-spectrum…”
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Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot by Neupane, Krishna, Munshi, Sneha, Zhao, Meng, Ritchie, Dustin B., Ileperuma, Sandaru M., Woodside, Michael T.

“…SARS-CoV-2 uses −1 programmed ribosomal frameshifting (−1 PRF) to control expression of key viral proteins. Because modulating −1 PRF can attenuate the virus,…”
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Anti-Frameshifting Ligand Active against SARS Coronavirus-2 is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot by Neupane, Krishna, Munshi, Sneha, Zhao, Meng, Ritchie, Dustin, Ileperuma, Sandaru M., Woodside, Michael T.

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