Search Results - "Ilchuk, Leonid A"
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Genetically Engineered Mice Unveil In Vivo Roles of the Mediator Complex
Published in International journal of molecular sciences (26-05-2023)“…The Mediator complex is a multi-subunit protein complex which plays a significant role in the regulation of eukaryotic gene transcription. It provides a…”
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Limitations of Tamoxifen Application for In Vivo Genome Editing Using Cre/ERT2 System
Published in International journal of molecular sciences (15-11-2022)“…Inducible Cre-dependent systems are frequently used to produce both conditional knockouts and transgenic mice with regulated expression of the gene of…”
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Transgenic mice Cre-dependently expressing mutant polymerase-gamma: novel test-system for pharmacological study of mitoprotective drugs
Published in Research results in pharmacology (English ed.) (17-09-2021)“…Introduction: PolG-alpha is a nuclear-encoded enzyme which provides replication and repair of mitochondrial DNA. D257A mutation of PolG-alpha leads to change…”
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Macrophages derived from LPS-stimulated monocytes from individuals with subclinical atherosclerosis were characterized by increased pro-inflammatory activity
Published in Cytokine (Philadelphia, Pa.) (01-12-2023)“…Atherosclerosis is characterized by chronic inflammation in the vascular wall. Currently the violation of immune tolerance of innate immune cells is considered…”
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AAV infection of bovine embryos: Novel, simple and effective tool for genome editing
Published in Theriogenology (01-11-2022)“…Adeno-associated viruses (AAV) are widely used in the field of genetically modified organism production. In this work, transduction of bovine embryos by AAV…”
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Novel transgenic mice with Cre-dependent co-expression of GFP and human ACE2: a safe tool for study of COVID-19 pathogenesis
Published in Transgenic research (01-06-2021)“…The current coronavirus disease (COVID-19) pandemic remains one of the most serious public health problems. Increasing evidence shows that infection by severe…”
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Limitations of Tamoxifen Application for In Vivo Genome Editing Using Cre/ER T2 System
Published in International journal of molecular sciences (15-11-2022)“…Inducible Cre-dependent systems are frequently used to produce both conditional knockouts and transgenic mice with regulated expression of the gene of…”
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