Search Results - "Ilangovan, Govindasamy"

Forced Expression of Heat Shock Protein 27 (Hsp27) Reverses P-Glycoprotein (ABCB1)-mediated Drug Efflux and MDR1 Gene Expression in Adriamycin-resistant Human Breast Cancer Cells by Kanagasabai, Ragu, Krishnamurthy, Karthikeyan, Druhan, Lawrence J., Ilangovan, Govindasamy

“…Mutant p53 accumulation has been shown to induce the multidrug resistance gene (MDR1) and ATP binding cassette (ABC)-based drug efflux in human breast cancer…”
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Heat shock factor-1 knockout induces multidrug resistance gene, MDR1b, and enhances P-glycoprotein (ABCB1)-based drug extrusion in the heart by Krishnamurthy, Karthikeyan, Vedam, Kaushik, Kanagasabai, Ragu, Druhan, Lawrence J., Ilangovan, Govindasamy

“…Heat-shock factor 1 (HSF-1), a transcription factor for heat-shock proteins (HSPs), is known to interfere with the transcriptional activity of many oncogenic…”
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Discovering a Reliable Heat-Shock Factor-1 Inhibitor to Treat Human Cancers: Potential Opportunity for Phytochemists by Velayutham, Murugesan, Cardounel, Arturo J, Liu, Zhenguo, Ilangovan, Govindasamy

“…Heat-shock factor-1 (HSF-1) is an important transcription factor that regulates pathogenesis of many human diseases through its extensive transcriptional…”
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Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice by Vedam, Kaushik, Nishijima, Yoshinori, Druhan, Lawrence J, Khan, Mahmood, Moldovan, Nicanor I, Zweier, Jay L, Ilangovan, Govindasamy

“…Treating cancer patients with chemotherapeutics, such as doxorubicin (Dox), cause dilated cardiomyopathy and congestive heart failure because of oxidative…”
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Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27 by Venkatakrishnan, C D, Tewari, Arun K, Moldovan, Leni, Cardounel, Arturo J, Zweier, Jay L, Kuppusamy, Periannan, Ilangovan, Govindasamy

“…Doxorubicin (DOX) and its derivatives are used as chemotherapeutic drugs to treat cancer patients. However, production of DOX-mediated reactive oxygen species…”
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Novel particulate spin probe for targeted determination of oxygen in cells and tissues by Pandian, Ramasamy P, Parinandi, Narasimham L, Ilangovan, Govindasamy, Zweier, Jay L, Kuppusamy, Periannan

“…The synthesis and characterization of a new lithium octa- n-butoxy-substituted naphthalocyanine radical probe (LiNc-BuO) and its use in the determination of…”
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HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest by Venkatakrishnan, C D, Dunsmore, Kathy, Wong, Hector, Roy, Sashwathi, Sen, Chandan K, Wani, Altaf, Zweier, Jay L, Ilangovan, Govindasamy

“…Treatment of cancer patients with anthracyclin-based chemotherapeutic drugs induces congestive heart failure by a mechanism involving p53. However, it is not…”
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Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite by Jones, 3rd, Charles I, Han, Zhaosheng, Presley, Tennille, Varadharaj, Saradhadevi, Zweier, Jay L, Ilangovan, Govindasamy, Alevriadou, B Rita

“…Cultured vascular endothelial cell (EC) exposure to steady laminar shear stress results in peroxynitrite (ONOO(-)) formation intramitochondrially and…”
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In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: Effect of carbogen-breathing by Ilangovan, Govindasamy, Li, Haiquan, Zweier, Jay L., Krishna, Murali C., Mitchell, James B., Kuppusamy, Periannan

“…The purpose of this study was to noninvasively monitor tumor oxygenation and redox status during hyperoxygenation treatment, such as carbogen‐breathing, in a…”
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Heat shock factor 1 determines the phenotype of tumor associated macrophages by Ilangovan, Govindasamy, Kanagasabai, Ragu

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Mechanism of oxygen-induced EPR line broadening in lithium phthalocyanine microcrystals by Ilangovan, Govindasamy, Zweier, Jay L., Kuppusamy, Periannan

“…EPR oximetry has been recognized as an important tool for determining oxygen concentration in biological tissues, in vivo. The method relies on the use of…”
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Electrochemical Preparation and EPR Studies of Lithium Phthalocyanine:  Evaluation of the Nucleation and Growth Mechanism and Evidence for Potential-Dependent Phase Formation by Ilangovan, Govindasamy, Zweier, Jay L, Kuppusamy, Periannan

“…A very reliable and reproducible electrochemical preparative procedure to obtain oxygen-sensitive lithium phthalocyanine (LiPc) microcrystalline powder, a…”
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Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells by Ilangovan, Govindasamy, Venkatakrishnan, C D, Bratasz, Anna, Osinbowale, Sola, Cardounel, Arturo J, Zweier, Jay L, Kuppusamy, Periannan

“…A mild heat shock (hyperthermia) protects cells from apoptotic and necrotic deaths by inducing overexpression of various heat shock proteins (Hsps). These…”
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EPR oximetry in the beating heart: Myocardial oxygen consumption rate as an index of postischemic recovery by Ilangovan, Govindasamy, Liebgott, Thibaut, Kutala, Vijay Kumar, Petryakov, Sergey, Zweier, Jay L., Kuppusamy, Periannan

“…Oxygen plays a critical role in the pathophysiology of myocardial injury during both ischemia and subsequent reperfusion (I/R). Thus, oxygen concentration is…”
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In vivo measurement and imaging of tumor oxygenation using coembedded paramagnetic particulates by Ilangovan, Govindasamy, Bratasz, Anna, Li, Haiquan, Schmalbrock, Petra, Zweier, Jay L., Kuppusamy, Periannan

“…Tumor tissue oxygenation is an important parameter that is positively correlated to the chemo‐ or radiation treatment outcome of certain tumors. Hence, methods…”
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A naphthalocyanine-based EPR probe for localized measurements of tissue oxygenation by Ilangovan, Govindasamy, Manivannan, Ayyakkannu, Li, Haiquan, Yanagi, Hisao, Zweier, Jay L., Kuppusamy, Periannan

“…A new electron paramagnetic resonance (EPR) oximetry probe, based on a naphthalocyanine macrocycle, is reported to exhibit high oxygen sensitivity and…”
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Electrochemical Preparation and EPR Studies of Lithium Phthalocyanine. Part 2:  Particle-Size-Dependent Line Broadening by Molecular Oxygen and Its Implications as an Oximetry Probe by Ilangovan, Govindasamy, Zweier, Jay L, Kuppusamy, Periannan

“…As an extension of our previous report (Ilangovan, G.; Zweier, J. L.; Kuppusamy, P. J. Phys. Chem. B 2000, 104, 4047) on the synthesis and characterization of…”
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Heat shock regulates the respiration of cardiac H9c2 cells through upregulation of nitric oxide synthase by Ilangovan, Govindasamy, Osinbowale, Sola, Bratasz, Anna, Bonar, Mary, Cardounel, Arturo J, Zweier, Jay L, Kuppusamy, Periannan

“…Mild and nonlethal heat shock (i.e., hyperthermia) is known to protect the myocardium and cardiomyocytes against ischemic injury. In the present study, we have…”
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Square-Wave Voltammetric Determination and ac Impedance Study of Dopamine on Preanodized Perfluorosulfonated Ionomer-Coated Glassy Carbon Electrodes by Zen, Jyh-Myng, Ilangovan, Govindasamy, Jou, Jia-Jen

“…Preanodization of the Nafion-coated glassy carbon electrode (NCGCE) results in a large increase in the square-wave voltammetric peak current of dopamine (DA)…”
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HSF-1 Deletion Attenuates Atherosclerosis by Enhancing CYP7A1 and Multidrug Transporter (MDR1) Gene Expressions by Karthikeyean, Krishanamoorthy, Ilangovan, Govindasamy

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