Search Results - "Ilag, Leopold L."

Diatoms: a novel source for the neurotoxin BMAA in aquatic environments by Jiang, Liying, Eriksson, Johan, Lage, Sandra, Jonasson, Sara, Shams, Shiva, Mehine, Martin, Ilag, Leopold L, Rasmussen, Ulla

“…Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease is a neurological disorder linked to environmental exposure to a non-protein amino acid,…”
Get full text

A Hairpin Motif in the Amyloid‑β Peptide Is Important for Formation of Disease-Related Oligomers by Khaled, Mohammed, Rönnbäck, Isabel, Ilag, Leopold L., Gräslund, Astrid, Strodel, Birgit, Österlund, Nicklas

“…The amyloid-β (Aβ) peptide is associated with the development of Alzheimer’s disease and is known to form highly neurotoxic prefibrillar oligomeric aggregates,…”
Get full text

Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure by Jonasson, Sara, Eriksson, Johan, Berntzon, Lotta, Spáčil, Zdeněk, llag, Leopold L., Ronnevi, Lars-Olof, Rasmussen, Ulla, Bergman, Birgitta, Karl, David

“…β-methylamino-L-alanine (BMAA), a neurotoxic nonprotein amino acid produced by most cyanobacteria, has been proposed to be the causative agent of devastating…”
Get full text

Cyanobacteria produce N-(2-aminoethyl)glycine, a backbone for peptide nucleic acids which may have been the first genetic molecules for life on Earth by Banack, Sandra Anne, Metcalf, James S, Jiang, Liying, Craighead, Derek, Ilag, Leopold L, Cox, Paul Alan

“…Prior to the evolution of DNA-based organisms on earth over 3.5 billion years ago it is hypothesized that RNA was the primary genetic molecule. Before…”
Get full text

Multimodal Spectroscopic Imaging of Pea Root Nodules to Assess the Nitrogen Fixation in the Presence of Biofertilizer Based on Nod-Factors by Susniak, Katarzyna, Krysa, Mikolaj, Kidaj, Dominika, Szymanska-Chargot, Monika, Komaniecka, Iwona, Zamlynska, Katarzyna, Choma, Adam, Wielbo, Jerzy, Ilag, Leopold L, Sroka-Bartnicka, Anna

“…Multimodal spectroscopic imaging methods such as Matrix Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI), Fourier Transform Infrared…”
Get full text

Host cell-derived lactate functions as an effector molecule in Neisseria meningitidis microcolony dispersal by Sigurlásdóttir, Sara, Engman, Jakob, Eriksson, Olaspers Sara, Saroj, Sunil D, Zguna, Nadezda, Lloris-Garcerá, Pilar, Ilag, Leopold L, Jonsson, Ann-Beth

“…The development of meningococcal disease, caused by the human pathogen Neisseria meningitidis, is preceded by the colonization of the epithelial layer in the…”
Get full text

Protein association of the neurotoxin and non-protein amino acid BMAA (β-N-methylamino-l-alanine) in the liver and brain following neonatal administration in rats by Karlsson, Oskar, Jiang, Liying, Andersson, Marie, Ilag, Leopold L., Brittebo, Eva B.

“…•Autoradiographic imaging showed BMAA uptake in tissues with high protein synthesis.•UHPLC–MS/MS showed dose-dependent protein-association of BMAA.•More than…”
Get full text

Identification of proteins from human permanent erupted enamel by Castiblanco, Gina A., Rutishauser, Dorothea, Ilag, Leopold L., Martignon, Stefania, Castellanos, Jaime E., Mejía, Wilson

“…Proteins from the extracellular matrix of enamel are highly specific and necessary for proper enamel formation. Most proteins are removed from the matrix by…”
Get full text

A Collaborative Evaluation of LC-MS/MS Based Methods for BMAA Analysis: Soluble Bound BMAA Found to Be an Important Fraction by Faassen, Elisabeth J, Antoniou, Maria G, Beekman-Lukassen, Wendy, Blahova, Lucie, Chernova, Ekaterina, Christophoridis, Christophoros, Combes, Audrey, Edwards, Christine, Fastner, Jutta, Harmsen, Joop, Hiskia, Anastasia, Ilag, Leopold L, Kaloudis, Triantafyllos, Lopicic, Srdjan, Lürling, Miquel, Mazur-Marzec, Hanna, Meriluoto, Jussi, Porojan, Cristina, Viner-Mozzini, Yehudit, Zguna, Nadezda

“…Exposure to β-N-methylamino-l-alanine (BMAA) might be linked to the incidence of amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease…”
Get full text

Mass Measurements of Increased Accuracy Resolve Heterogeneous Populations of Intact Ribosomes by McKay, Adam R, Ruotolo, Brandon T, Ilag, Leopold L, Robinson, Carol V

“…It is established that noncovalent complexes can be maintained both during and after electrospray and that assemblies of increasing size and complexity often…”
Get full text

The Fate of a Hapten - From the Skin to Modification of Macrophage Migration Inhibitory Factor (MIF) in Lymph Nodes by Karlsson, Isabella, Samuelsson, Kristin, Simonsson, Carl, Stenfeldt, Anna-Lena, Nilsson, Ulrika, Ilag, Leopold L., Jonsson, Charlotte, Karlberg, Ann-Therese

“…Skin (contact) allergy, the most prevalent form of immunotoxicity in humans, is caused by low molecular weight chemicals (haptens) that penetrate stratum…”
Get full text

The amyloid-inhibiting NCAM-PrP peptide targets Aβ peptide aggregation in membrane-mimetic environments by Król, Sylwia, Österlund, Nicklas, Vosough, Faraz, Jarvet, Jüri, Wärmländer, Sebastian, Barth, Andreas, Ilag, Leopold L., Magzoub, Mazin, Gräslund, Astrid, Mörman, Cecilia

“…Substantial research efforts have gone into elucidating the role of protein misfolding and self-assembly in the onset and progression of Alzheimer’s disease…”
Get full text

Protein Complexes of the Escherichia coli Cell Envelope by Stenberg, Filippa, Chovanec, Peter, Maslen, Sarah L., Robinson, Carol V., Ilag, Leopold L., von Heijne, Gunnar, Daley, Daniel O.

“…Protein complexes are an intrinsic aspect of life in the membrane. Knowing which proteins are assembled in these complexes is therefore essential to…”
Get full text

Analytical protocol for identification of BMAA and DAB in biological samples by Spácil, Zdenek, Eriksson, Johan, Jonasson, Sara, Rasmussen, Ulla, Ilag, Leopold L, Bergman, Birgitta

“…Beta-N-methylamino-L-alanine (BMAA) is a non-protein amino acid, thought to be inflicting neurodegenerative diseases related to ALS/PDC in human beings. Due to…”
Get more information

Heptameric ( L12)6/ L10 Rather Than Canonical Pentameric Complexes Are Found by Tandem MS of Intact Ribosomes from Thermophilic Bacteria by Ilag, Leopold L., Videler, Hortense, McKay, Adam R., Sobott, Frank, Fucini, Paola, Nierhaus, Knud H., Robinson, Carol V., Moore, Peter B.

“…Ribosomes are universal translators of the genetic code into protein and represent macromolecular structures that are asymmetric, often heterogeneous, and…”
Get full text

Monosaccharide compositional analysis of marine polysaccharides by hydrophilic interaction liquid chromatography-tandem mass spectrometry by Gao, Qiuju, Nilsson, Ulrika, Ilag, Leopold L, Leck, Caroline

“…A simple and sensitive method was developed using hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry for determination of…”
Get full text

Abiotic synthesis of amino acids and self-crystallization under prebiotic conditions by Jiang, Liying, Dziedzic, Pawel, Spacil, Zdenek, Zhao, Gui-Ling, Nilsson, Lennart, Ilag, Leopold L., Córdova, Armando

“…Building on previous research on the origin and homochirality of life, this study focuses on analyses profiling important building blocks of life: the natural…”
Get full text

Native Ion Mobility-Mass Spectrometry Reveals the Formation of β‑Barrel Shaped Amyloid‑β Hexamers in a Membrane-Mimicking Environment by Österlund, Nicklas, Moons, Rani, Ilag, Leopold L, Sobott, Frank, Gräslund, Astrid

“…The mechanisms behind the Amyloid-β (Aβ) peptide neurotoxicity in Alzheimer’s disease are intensely studied and under debate. One suggested mechanism is that…”
Get full text

Detection of Benzo[ a ]pyrene Diol Epoxide Adducts to Histidine and Lysine in Serum Albumin In Vivo by High-Resolution-Tandem Mass Spectrometry by Zurita, Javier, Motwani, Hitesh V, Ilag, Leopold L, Souliotis, Vassilis L, Kyrtopoulos, Soterios A, Nilsson, Ulrika, Törnqvist, Margareta

“…Electrophilic diol epoxide metabolites are involved in the carcinogenicity of benzo[ ]pyrene, one of the widely studied polycyclic aromatic hydrocarbons…”
Get full text

Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation by Österlund, Nicklas, Lundqvist, Martin, Ilag, Leopold L., Gräslund, Astrid, Emanuelsson, Cecilia

“…A human molecular chaperone protein, DnaJ heat shock protein family (Hsp40) member B6 (DNAJB6), efficiently inhibits amyloid aggregation. This inhibition…”
Get full text