Search Results - "Ikuta, Naoko"

Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats by Uchida, Ryota, Okamoto, Hinako, Ikuta, Naoko, Terao, Keiji, Hirota, Takashi

“…α-Lipoic acid (LA) is widely used for nutritional supplements as a racemic mixture, even though the R enantiomer is biologically active. After oral…”
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Inactivation of the PD-1-Dependent Immunoregulation in Mice Exacerbates Contact Hypersensitivity Resembling Immune-Related Adverse Events by Ashoori, Matin Dokht, Suzuki, Kensuke, Tokumaru, Yosuke, Ikuta, Naoko, Tajima, Masaki, Honjo, Tasuku, Ohta, Akio

“…Blockade of PD-1, an indispensable physiological immunoregulatory mechanism, enhances immune activities and is widely used in the immunotherapy of cancer. This…”
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Bioavailability of an R-α-Lipoic Acid/γ-Cyclodextrin Complex in Healthy Volunteers by Ikuta, Naoko, Okamoto, Hinako, Furune, Takahiro, Uekaji, Yukiko, Terao, Keiji, Uchida, Ryota, Iwamoto, Kosuke, Miyajima, Atsushi, Hirota, Takashi, Sakamoto, Norihiro

“…R-α-lipoic acid (R-LA) is a cofactor of mitochondrial enzymes and a very strong antioxidant. R-LA is available as a functional food ingredient but is unstable…”
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Anti-obesity effects of α-cyclodextrin-stabilized 4-methylthio-3-butenyl isothiocyanate from daikon (Raphanus sativus var. longipinnatus) in mice by Okamoto, Hinako, Ino, Syoko, Nihei, Nanako, Ikuta, Naoko, Ueno, Chihiro, Itoi, Aya, Yoshikawa, Yutaka, Terao, Keiji, Sakamoto, Norihiro

“…4-Methylthio-3-butenyl isothiocyanate (MTBI) is a pungent bioactive constituent found in daikon. However, MTBI is immediately hydrolyzed to…”
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Investigation of Enantioselective Membrane Permeability of α-Lipoic Acid in Caco-2 and MDCKII Cell by Uchida, Ryota, Okamoto, Hinako, Ikuta, Naoko, Terao, Keiji, Hirota, Takashi

“…α-Lipoic acid (LA) contains a chiral carbon and exists as two enantiomers (R-α-lipoic acid (RLA) and S-α-lipoic acid (SLA)). We previously demonstrated that…”
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Spectroscopic studies of R(+)-α-lipoic acid--cyclodextrin complexes by Ikuta, Naoko, Tanaka, Akira, Otsubo, Ayako, Ogawa, Noriko, Yamamoto, Hiromitsu, Mizukami, Tomoyuki, Arai, Shoji, Okuno, Masayuki, Terao, Keiji, Matsugo, Seiichi

“…α-Lipoic acid (ALA) has a chiral center at the C6 position, and exists as two enantiomers, R(+)-ALA (RALA) and S(-)-ALA (SALA). RALA is naturally occurring,…”
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Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells by Ikuta, Naoko, Chikamoto, Keita, Asano, Yuya, Yasui, Yoshiaki, Yokokawa, Haruka, Terao, Keiji, Rimbach, Gerald, Matsugo, Seiichi

“…Alpha-lipoic acid (LA) is a powerful antioxidant. LA has two enantiomers, R(+)-LA (R-LA) and S(-)-LA (S-LA). Of these, R-LA is naturally occurring and an…”
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Analysis of the enhanced stability of r(+)-alpha lipoic Acid by the complex formation with cyclodextrins by Ikuta, Naoko, Sugiyama, Hironori, Shimosegawa, Hiroshi, Nakane, Rie, Ishida, Yoshiyuki, Uekaji, Yukiko, Nakata, Daisuke, Pallauf, Kathrin, Rimbach, Gerald, Terao, Keiji, Matsugo, Seiichi

“…R(+)-alpha lipoic acid (RALA) is one of the cofactors for mitochondrial enzymes and, therefore, plays a central role in energy metabolism. RALA is unstable…”
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Effect of γ-Cyclodextrin Inclusion Complex on the Absorption of R-α-Lipoic Acid in Rats by Uchida, Ryota, Iwamoto, Kosuke, Nagayama, Suetada, Miyajima, Atsushi, Okamoto, Hinako, Ikuta, Naoko, Fukumi, Hiroshi, Terao, Keiji, Hirota, Takashi

“…R-α-lipoic acid (RLA) is an endogenous organic acid, and works as a cofactor for mitochondrial enzymes and as a kind of antioxidant. Inclusion complexes of RLA…”
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NMR Studies of Inclusion Complexes Formed by (R)-α-Lipoic Acid with α-, β-, and γ-Cyclodextrins by Ikeda, Hiroshi, Ikuta, Naoko, Nakata, Daisuke, Ishida, Yoshiyuki, Terao, Keiji

“…The structures of inclusion complexes of (R)-α-lipoic acid with α-, β-, and γ-cyclodextrin (CD) were constructed using restraints derived from ROESY spectra…”
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A study on the inhibitory mechanism for cholesterol absorption by α-cyclodextrin administration by Furune, Takahiro, Ikuta, Naoko, Ishida, Yoshiyuki, Okamoto, Hinako, Nakata, Daisuke, Terao, Keiji, Sakamoto, Norihiro

“…Micelle formation of cholesterol with lecithin and bile salts is a key process for intestinal absorption of lipids. Some dietary fibers commonly used to reduce…”
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R-α lipoic acid γ-cyclodextrin complex increases energy expenditure: A 4-month feeding study in mice by Nikolai, Sibylle, M.Sc, Huebbe, Patricia, Ph.D, Metges, Cornelia C., Ph.D, Schloesser, Anke, M.Sc, Dose, Janina, M.Sc, Ikuta, Naoko, M.Sc, Terao, Keiji, Ph.D, Matsugo, Seiichi, Prof, Rimbach, Gerald, Prof

“…Abstract Objective A high-fat diet (HFD) affects energy expenditure in laboratory rodents. R-α lipoic acid cyclodextrin (RALA-CD) complex is a stable form of…”
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Structural Analysis of Crystalline R(+)-α-Lipoic Acid-α-cyclodextrin Complex Based on Microscopic and Spectroscopic Studies by Ikuta, Naoko, Endo, Takatsugu, Hosomi, Shota, Setou, Keita, Tanaka, Shiori, Ogawa, Noriko, Yamamoto, Hiromitsu, Mizukami, Tomoyuki, Arai, Shoji, Okuno, Masayuki, Takahashi, Kenji, Terao, Keiji, Matsugo, Seiichi

“…R(+)-α-lipoic acid (RALA) is a naturally-occurring substance, and its protein-bound form plays significant role in the energy metabolism in the mitochondria…”
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Antidiabetic effect of the α-lipoic acid γ-cyclodextrin complex by Naito, Yuki, Ikuta, Naoko, Nakata, Daisuke, Terao, Keiji, Matsumoto, Kinuyo, Kajiwara, Naemi, Okano, Ayaka, Yasui, Hiroyuki, Yoshikawa, Yutaka

“…In recent years, the number of patients suffering from diabetes mellitus has been increasing worldwide. In particular, type 2 diabetes mellitus, a…”
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Biaxial Tensile Properties of Thoracic Aortic Aneurysm Tissues by Takeo MATSUMOTO, Tomohiro FUKUI, Toshihiro TANAKA, Naoko IKUTA, Toshiro OHASHI, Kiichiro KUMAGAI, Hiroji AKIMOTO, Koichi TABAYASHI, Masaaki SATO

“…Mechanical properties of human aortic aneurysm tissues were measured with a biaxial tensile tester. Fifteen-mm-square specimens were obtained from thoracic…”
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Dietary α‐cyclodextrin modifies gut microbiota and reduces fat accumulation in high‐fat‐diet‐fed obese mice by Nihei, Nanako, Okamoto, Hinako, Furune, Takahiro, Ikuta, Naoko, Sasaki, Kengo, Rimbach, Gerald, Yoshikawa, Yutaka, Terao, Keiji

“…We investigated the effect of α‐cyclodextrin (α‐CD) on the bacterial populations of gut microbiota, production of organic acids, and short‐chain fatty acids…”
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Low amounts of dietary fibre increase in vitro production of short-chain fatty acids without changing human colonic microbiota structure by Sasaki, Daisuke, Sasaki, Kengo, Ikuta, Naoko, Yasuda, Takahiro, Fukuda, Itsuko, Kondo, Akihiko, Osawa, Ro

“…This study investigated the effect of various prebiotics (indigestible dextrin, α-cyclodextrin, and dextran) on human colonic microbiota at a dosage…”
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Anti-Inflammatory Properties of Brazilian Green Propolis Encapsulated in a γ-Cyclodextrin Complex in Mice Fed a Western-Type Diet by Rimbach, Gerald, Fischer, Alexandra, Schloesser, Anke, Jerz, Gerold, Ikuta, Naoko, Ishida, Yoshiyuki, Matsuzawa, Ryota, Matsugo, Seiichi, Huebbe, Patricia, Terao, Keiji

“…Ageing is often accompanied by chronic inflammation. A fat- and sugar-rich Western-type diet (WTD) may accelerate the ageing phenotype. Cell culture studies…”
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Investigation of Enantioselective Membrane Permeability of [alpha]-Lipoic Acid in Caco-2 and MDCKII Cell by Uchida, Ryota, Okamoto, Hinako, Ikuta, Naoko, Terao, Keiji, Hirota, Takashi

“…[alpha]-Lipoic acid (LA) contains a chiral carbon and exists as two enantiomers (R-[alpha]-lipoic acid (RLA) and S-[alpha]-lipoic acid (SLA)). We previously…”
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Enantioselective Pharmacokinetics of [alpha]-Lipoic Acid in Rats by Uchida, Ryota, Okamoto, Hinako, Ikuta, Naoko, Terao, Keiji, Hirota, Takashi

“…[alpha]-Lipoic acid (LA) is widely used for nutritional supplements as a racemic mixture, even though the R enantiomer is biologically active. After oral…”
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