Search Results - "Ikushiro, Shin'ichi"

Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT by Miyauchi, Yuu, Kurita, Ayumi, Yamashita, Ryohei, Takamatsu, Tomoyuki, Ikushiro, Shin’ichi, Mackenzie, Peter I., Tanaka, Yoshitaka, Ishii, Yuji

“…UDP-Glucuronosyltransferase (UGT, Ugt) is a major drug metabolizing enzyme family involved in the glucuronidation and subsequent elimination of drugs and small…”
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Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants by Ishii, Yuji, Koba, Hiroki, Kinoshita, Kousuke, Oizaki, Toshiya, Iwamoto, Yuki, Takeda, Shuso, Miyauchi, Yuu, Nishimura, Yoshio, Egoshi, Natsuki, Taura, Futoshi, Morimoto, Satoshi, Ikushiro, Shin'ichi, Nagata, Kiyoshi, Yamazoe, Yasushi, Mackenzie, Peter I, Yamada, Hideyuki

“…Functional protein-protein interactions between UDP-glucuronosyltransferase (UGT)1A isoforms and cytochrome P450 (CYP)3A4 were studied. To this end,…”
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Comparison of metabolism and biological properties among positional isomers of quercetin glucuronide in LPS- and RANKL-challenged RAW264.7 cells by Nishikawa, Miyu, Kada, Yuriko, Kimata, Mirai, Sakaki, Toshiyuki, Ikushiro, Shinichi

“…ABSTRACT The major quercetin metabolite, quercetin-3-glucuronide, exerts various biological activities, including anti-inflammatory effects. This study aimed…”
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Transfer of quercetin ingested by maternal mice to neonatal mice via breast milk by Fujiwara, Nao, Mukai, Rie, Nishikawa, Miyu, Ikushiro, Shinichi, Murakami, Akira, Ishisaka, Akari

“…ABSTRACT This is the first study that quantified quercetin (QUE) and its 16 metabolites in the breast milk of QUE-fed maternal mice, the plasma and urine of…”
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Effect of Wheat-Derived Arabinoxylan on the Gut Microbiota Composition and Colonic Regulatory T Cells by Chudan, Seita, Ishibashi, Riko, Nishikawa, Miyu, Tabuchi, Yoshiaki, Nagai, Yoshinori, Ikushiro, Shinichi, Furusawa, Yukihiro

“…The health benefits of wheat-derived arabinoxylan, a commonly consumed dietary fiber, have been studied for decades. However, its effect on the gut…”
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Beneficial Effects of Dietary Fiber in Young Barley Leaf on Gut Microbiota and Immunity in Mice by Chudan, Seita, Kurakawa, Takuto, Nishikawa, Miyu, Nagai, Yoshinori, Tabuchi, Yoshiaki, Ikushiro, Shinichi, Furusawa, Yukihiro

“…The health benefits of young barley leaves, rich in dietary fiber, have been studied for several decades; however, their beneficial effects on the intestinal…”
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Comparison of the stability of CYP105A1 and its variants engineered for production of active forms of vitamin D by Takita, Teisuke, Sakuma, Hiro, Ohashi, Ren, Nilouyal, Somaye, Nemoto, Sho, Wada, Moeka, Yogo, Yuya, Yasuda, Kaori, Ikushiro, Shinichi, Sakaki, Toshiyuki, Yasukawa, Kiyoshi

“…CYP105A1 from Streptomyces griseolus converts vitamin D3 to its biologically active form, 1α,25-dihydroxy vitamin D3. R73A/R84A mutation enhanced the 1α- and…”
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Regioselective Glucuronidation of Flavones at C5, C7, and C4′ Positions in Human Liver and Intestinal Microsomes: Comparison among Apigenin, Acacetin, and Genkwanin by Hanioka, Nobumitsu, Tanaka-Kagawa, Toshiko, Mori, Yoko, Ikushiro, Shinichi, Jinno, Hideto, Ohkawara, Susumu, Isobe, Takashi

“…Flavones, which are distributed in a variety of plants and foods in nature, possess significant biological activities, including antitumor and…”
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Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation by Kurita, Ayumi, Miyauchi, Yuu, Ikushiro, Shin'ichi, Mackenzie, Peter I, Yamada, Hideyuki, Ishii, Yuji

“…UDP-Glucuronosyltransferases (UGTs) are classified into three subfamilies in mice: Ugt1a, 2b, and 2a. In the subfamily, and appear to correspond to human and…”
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Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector by Kise, Satoko, Iijima, Ayano, Nagao, Chika, Okada, Tadashi, Nishikawa, Miyu, Ikushiro, Shinichi, Nakanishi, Tomoko, Sato, Shigeto, Yasuda, Kaori, Sakaki, Toshiyuki

“…Type II rickets is a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. The main symptoms of this disease are bone dysplasia and…”
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Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice by Ishibashi, Riko, Furusawa, Yukihiro, Honda, Hiroe, Watanabe, Yasuharu, Fujisaka, Shiho, Nishikawa, Miyu, Ikushiro, Shinichi, Kurihara, Shin, Tabuchi, Yoshiaki, Tobe, Kazuyuki, Takatsu, Kiyoshi, Nagai, Yoshinori

“…Scope Isoliquiritigenin (ILG) has been reported to attenuate adipose tissue inflammation and metabolic disorder; however, the underlying mechanisms remain to…”
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Effect of soluble oat fiber on intestinal microenvironment and TNBS-induced colitis by Chudan, Seita, Ishibashi, Riko, Nishikawa, Miyu, Tabuchi, Yoshiaki, Nagai, Yoshinori, Ikushiro, Shinichi, Furusawa, Yukihiro

“…Soluble oat fibers, including β-glucan, have been shown to alter the gut microbiome composition and ameliorate DSS-induced colitis; however, the beneficial…”
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Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator by Mano, Hiroki, Takano, Masashi, Ikushiro, Shinichi, Kittaka, Atsushi, Sakaki, Toshiyuki

“…Vitamin D receptor (VDR) ligands, such as 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] and its analogs, have been investigated for their potential clinical use in…”
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Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique by Mano, Hiroki, Ikushiro, Shinichi, Saito, Nozomi, Kittaka, Atsushi, Sakaki, Toshiyuki

“…•Chimeric protein between split-luciferase and vitamin D receptor was constructed.•In vitro screening system for VDR ligands was established using this…”
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Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats by Nishikawa, Miyu, Murose, Naruhiro, Mano, Hiroki, Yasuda, Kaori, Isogai, Yasuhiro, Kittaka, Atsushi, Takano, Masashi, Ikushiro, Shinichi, Sakaki, Toshiyuki

“…Active vitamin D form 1α,25-dihydroxtvitamin D 3 (1,25(OH) 2 D 3 ) plays pivotal roles in calcium homeostasis and osteogenesis via its transcription regulation…”
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Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin by Tanaka, Seiya, Oyama, Manami, Nishikawa, Miyu, Ikushiro, Shinichi, Hara, Hiroshi

“…Quercetin is a flavonoid with many physiological effects. Absorbed quercetin is rapidly conjugated in the intestinal epithelium and liver. Different positional…”
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Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions by Nishikawa, Miyu, Yasuda, Kaori, Takamatsu, Masashi, Abe, Keisuke, Okamoto, Kairi, Horibe, Kyohei, Mano, Hiroki, Nakagawa, Kimie, Tsugawa, Naoko, Hirota, Yoshihisa, Horie, Tetsuhiro, Hinoi, Eiichi, Okano, Toshio, Ikushiro, Shinichi, Sakaki, Toshiyuki

“…Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1α,25-dihydroxyvitamin D 3…”
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Transgenic Zebrafish Expressing Rat Cytochrome P450 2E1 (CYP2E1): Augmentation of Acetaminophen-Induced Toxicity in the Liver and Retina by Sato, Yoshinori, Dong, Wenjing, Nakamura, Tatsuro, Mizoguchi, Naohiro, Nawaji, Tasuku, Nishikawa, Miyu, Onaga, Takenori, Ikushiro, Shinichi, Kobayashi, Makoto, Teraoka, Hiroki

“…Metabolic activation is the primary cause of chemical toxicity including hepatotoxicity. Cytochrome P450 2E (CYP2E) is involved in this process for many…”
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Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery by Yasuda, Kaori, Nishikawa, Miyu, Mano, Hiroki, Takano, Masashi, Kittaka, Atsushi, Ikushiro, Shinichi, Sakaki, Toshiyuki

“…We have developed an in vitro system to easily examine the affinity for vitamin D receptor (VDR) and CYP24A1-mediated metabolism as two methods of assessing…”
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Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system by Yasuda, Kaori, Nishikawa, Miyu, Okamoto, Kairi, Horibe, Kyohei, Mano, Hiroki, Yamaguchi, Mana, Okon, Risa, Nakagawa, Kimie, Tsugawa, Naoko, Okano, Toshio, Kawagoe, Fumihiro, Kittaka, Atsushi, Ikushiro, Shinichi, Sakaki, Toshiyuki

“…CYP24A1-deficient (Cyp24a1 KO) rats were generated using the CRISPER/Cas9 system to investigate CYP24A1-dependent or -independent metabolism of 25(OH)D3, the…”
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