Search Results - "Ikuo Konishi"

Immune checkpoint inhibition in ovarian cancer by Hamanishi, Junzo, Mandai, Masaki, Konishi, Ikuo

“…Recent studies have shown that tumor cells acquire escape mechanisms to evade host immunity in the tumor microenvironment. Two key immune checkpoint pathways…”
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Validation of the 2018 FIGO cervical cancer staging system by Matsuo, Koji, Machida, Hiroko, Mandelbaum, Rachel S., Konishi, Ikuo, Mikami, Mikio

“…To validate the revised 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical cancer, with a particular focus on stage…”
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Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells by Horikawa, Naoki, Abiko, Kaoru, Matsumura, Noriomi, Hamanishi, Junzo, Baba, Tsukasa, Yamaguchi, Ken, Yoshioka, Yumiko, Koshiyama, Masafumi, Konishi, Ikuo

“…High VEGF expression in ovarian cancer is an unfavorable prognostic factor. However, the role of VEGF in tumor immunity remains unclear. Here, we examined the…”
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The Okabayashi Radical Hysterectomy: Basic Principle and Step-by-Step Procedure by Konishi, Ikuo

“…Abstract Abdominal radical hysterectomy is the standard operation for stage IB–IIB cervical cancer in the world, which was established by Professor Hidekazu…”
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Correlation of anti-tumour drug resistance with epigenetic regulation by Hayashi, Takuma, Konishi, Ikuo

“…Summary During treatment, the development of drug-resistant tumours remains an important challenge in cancer treatment. Epigenetic changes have been reported…”
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Cancer therapy with decreased SARS-CoV-2 infection rates in cancer patients by Hayashi, Takuma, Konishi, Ikuo

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Diffuse Leiomyomatosis: Complete Myomectomy for Innumerable Small Nodules to Achieve Fertility Sparing and Childbearing by Konishi, Ikuo

“…Abstract Diffuse leiomyomatosis is a rare condition among benign smooth muscle neoplasms of the uterus, being defined as innumerable small myomatous nodules…”
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Recent Concepts of Ovarian Carcinogenesis : Type I and Type II by Koshiyama, Masafumi, Matsumura, Noriomi, Konishi, Ikuo

“…Type I ovarian tumors, where precursor lesions in the ovary have clearly been described, include endometrioid, clear cell, mucinous, low grade serous, and…”
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PD-1/PD-L1 blockade in cancer treatment: perspectives and issues by Hamanishi, Junzo, Mandai, Masaki, Matsumura, Noriomi, Abiko, Kaoru, Baba, Tsukasa, Konishi, Ikuo

“…Recent studies showed that tumor cells ‘edit’ host immunity in several ways to evade immune defenses in the tumor microenvironment. This phenomenon is called…”
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Anti-VEGF therapy resistance in ovarian cancer is caused by GM-CSF-induced myeloid-derived suppressor cell recruitment by Horikawa, Naoki, Abiko, Kaoru, Matsumura, Noriomi, Baba, Tsukasa, Hamanishi, Junzo, Yamaguchi, Ken, Murakami, Ryusuke, Taki, Mana, Ukita, Masayo, Hosoe, Yuko, Koshiyama, Masafumi, Konishi, Ikuo, Mandai, Masaki

“…Background The mechanism of resistance development to anti-VEGF therapy in ovarian cancer is unclear. We focused on the changes in tumour immunity post…”
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Noneffect of SARS-CoV-2 spike glycoprotein Y217N mutation on affinity between the virus and ACE2 by Hayashi, Takuma, Konishi, Ikuo

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Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation by Taki, Mana, Abiko, Kaoru, Baba, Tsukasa, Hamanishi, Junzo, Yamaguchi, Ken, Murakami, Ryusuke, Yamanoi, Koji, Horikawa, Naoki, Hosoe, Yuko, Nakamura, Eijiro, Sugiyama, Aiko, Mandai, Masaki, Konishi, Ikuo, Matsumura, Noriomi

“…Snail is a major transcriptional factor that induces epithelial-mesenchymal transition (EMT). In this study, we explore the effect of Snail on tumor immunity…”
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Revised FIGO staging for carcinoma of the cervix uteri by Bhatla, Neerja, Berek, Jonathan S., Cuello Fredes, Mauricio, Denny, Lynette A., Grenman, Seija, Karunaratne, Kanishka, Kehoe, Sean T., Konishi, Ikuo, Olawaiye, Alexander B., Prat, Jaime, Sankaranarayanan, Rengaswamy

“…Objective To revise FIGO staging of carcinoma of the cervix uteri, allowing incorporation of imaging and/or pathological findings, and clinical assessment of…”
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Basic Principle and Step-by-Step Procedure of Abdominal Hysterectomy: Part 2 by Konishi, Ikuo

“…Abstract Abdominal hysterectomy is the ultimate standard operation among various gynecologic surgeries. However, the actual procedure for a patient varies…”
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Molecular Histopathology for Establishing Diagnostic Method and Clinical Therapy for Ovarian Carcinoma by Hayashi, Takuma, Konishi, Ikuo

“…Ovarian carcinoma (OC) is considered the deadliest gynecological malignancy. It is typically diagnosed in the advanced stages of the disease, with metastatic…”
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Prospects and Problems of Cancer Genome Analysis for Establishing Cancer Precision Medicine by Hayashi, Takuma, Konishi, Ikuo

“…The genome represents a design for creating the body, with each one being different. In cancer genomic medicine, many genes are simultaneously examined using…”
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Targeted therapy for gynecologic cancers: Toward the era of precision medicine by Basu, Partha, Mukhopadhyay, Asima, Konishi, Ikuo

“…Recent advances in molecular biology of cancer have led to the development of targeted agents, mainly of monoclonal antibodies and small‐molecule compounds…”
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Initialization of epithelial cells by tumor cells in a metastatic microenvironment by Hayashi, Takuma, Sano, Kenji, Aburatani, Hiroyuki, Yaegashi, Nobuo, Konishi, Ikuo

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PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction by Abiko, Kaoru, Mandai, Masaki, Hamanishi, Junzo, Yoshioka, Yumiko, Matsumura, Noriomi, Baba, Tsukasa, Yamaguchi, Ken, Murakami, Ryusuke, Yamamoto, Ayaka, Kharma, Budiman, Kosaka, Kenzo, Konishi, Ikuo

“…Ovarian cancer often progresses by disseminating to the peritoneal cavity, but how the tumor cells evade host immunity during this process is poorly…”
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Familial Gastrointestinal Stromal Tumor Associated with Zebra-like Pigmentation by Hayashi, Takuma, Konishi, Ikuo

“…According to clinical studies, gastrointestinal stromal tumors (GISTs) are predominantly sporadic. GISTs associated with familial syndromes are very rare, and…”
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