Search Results - "Ikram, M"

Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population by Licher, Silvan, Ahmad, Shahzad, Karamujić-Čomić, Hata, Voortman, Trudy, Leening, Maarten J. G., Ikram, M. Arfan, Ikram, M. Kamran

“…The exact etiology of dementia is still unclear, but both genetic and lifestyle factors are thought to be key drivers of this complex disease. The recognition…”
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Sleep and risk of parkinsonism and Parkinson's disease: a population-based study by Lysen, Thom S, Darweesh, Sirwan K L, Ikram, M Kamran, Luik, Annemarie I, Ikram, M Arfan

“…Sleep disturbances may signal presence of prodromal parkinsonism, including Parkinson's disease. Whether general sleep quality or duration in otherwise healthy…”
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Visit-to-visit blood pressure variability and the risk of stroke in the Netherlands: A population-based cohort study by Heshmatollah, Alis, Ma, Yuan, Fani, Lana, Koudstaal, Peter J, Ikram, M Arfan, Ikram, M Kamran

“…Apart from blood pressure level itself, variation in blood pressure has been implicated in the development of stroke in subgroups at high cardiovascular risk…”
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Epidemiology of Vascular Dementia: Nosology in a Time of Epiomics by Wolters, Frank J., Ikram, M. Arfan

“…The notion of what qualifies as vascular dementia has varied greatly since the first mention of dementia after apoplexy in ancient literature. Current insight…”
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The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study by van der Lee, Sven J, Wolters, Frank J, Ikram, M Kamran, Hofman, Albert, Ikram, M Arfan, Amin, Najaf, van Duijn, Cornelia M

“…Alzheimer's disease is one of the most heritable diseases in elderly people and the most common type of dementia. In addition to the major genetic determinant…”
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Objectives, design and main findings until 2020 from the Rotterdam Study by Ikram, M. Arfan, Brusselle, Guy, Ghanbari, Mohsen, Goedegebure, André, Ikram, M. Kamran, Kavousi, Maryam, Kieboom, Brenda C. T., Klaver, Caroline C. W., de Knegt, Robert J., Luik, Annemarie I., Nijsten, Tamar E. C., Peeters, Robin P., van Rooij, Frank J. A., Stricker, Bruno H., Uitterlinden, André G., Vernooij, Meike W., Voortman, Trudy

“…The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology,…”
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Exercise interventions for the prevention of depression: a systematic review of meta-analyses by Hu, Mandy X, Turner, David, Generaal, Ellen, Bos, Daniel, Ikram, M Kamran, Ikram, M Arfan, Cuijpers, Pim, Penninx, Brenda W J H

“…Exercise may be a promising target for depression interventions. However, evidence for a beneficial effect of exercise interventions on the prevention of…”
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Prevalence and determinants of healthcare avoidance during the COVID-19 pandemic: A population-based cross-sectional study by Splinter, Marije J, Velek, Premysl, Ikram, M Kamran, Kieboom, Brenda C T, Peeters, Robin P, Bindels, Patrick J E, Ikram, M Arfan, Wolters, Frank J, Leening, Maarten J G, de Schepper, Evelien I T, Licher, Silvan

“…During the Coronavirus Disease 2019 (COVID-19) pandemic, the number of consultations and diagnoses in primary care and referrals to specialist care declined…”
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Herpes simplex virus 1 and the risk of dementia: a population-based study by Murphy, Meghan J., Fani, Lana, Ikram, M. Kamran, Ghanbari, Mohsen, Ikram, M. Arfan

“…Herpes simplex virus 1 (HSV1) is a neuroinvasive virus capable of entering the brain which makes it a candidate pathogen for increasing risk of dementia…”
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Variation in blood pressure and long-term risk of dementia: A population-based cohort study by Ma, Yuan, Wolters, Frank J, Chibnik, Lori B, Licher, Silvan, Ikram, M Arfan, Hofman, Albert, Ikram, M Kamran

“…Variation in blood pressure may relate to dementia risk via autonomic disturbance or hemodynamic mechanisms, but the long-term associations are unclear. We…”
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Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study by Hilal, Saima, Wolters, Frank J, Verbeek, Marcel M, Vanderstichele, Hugo, Ikram, M Kamran, Stoops, Erik, Ikram, M Arfan, Vernooij, Meike W

“…Plasma amyloid-β (Aβ) levels are increasingly studied as a potential accessible marker of cognitive impairment and dementia. However, it remains underexplored…”
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Lifetime risk and multimorbidity of non-communicable diseases and disease-free life expectancy in the general population: A population-based cohort study by Licher, Silvan, Heshmatollah, Alis, van der Willik, Kimberly D, Stricker, Bruno H Ch, Ruiter, Rikje, de Roos, Emmely W, Lahousse, Lies, Koudstaal, Peter J, Hofman, Albert, Fani, Lana, Brusselle, Guy G O, Bos, Daniel, Arshi, Banafsheh, Kavousi, Maryam, Leening, Maarten J G, Ikram, M Kamran, Ikram, M Arfan

“…Non-communicable diseases (NCDs) are leading causes of premature disability and death worldwide. However, the lifetime risk of developing any NCD is unknown,…”
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The association of innate and adaptive immunity, subclinical atherosclerosis, and cardiovascular disease in the Rotterdam Study: A prospective cohort study by Fani, Lana, van der Willik, Kimberly D, Bos, Daniel, Leening, Maarten J G, Koudstaal, Peter J, Rizopoulos, Dimitris, Ruiter, Rikje, Stricker, Bruno H C, Kavousi, Maryam, Ikram, M Arfan, Ikram, M Kamran

“…Atherosclerotic cardiovascular disease (ASCVD) is driven by multifaceted contributions of the immune system. However, the dysregulation of immune cells that…”
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The use and misuse of ‘biological aging’ in health research by Ikram, M. Arfan

“…Biological aging clocks are flawed concepts in understanding disease…”
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Do Case-Control Studies Always Estimate Odds Ratios? by Labrecque, Jeremy A, Hunink, Myriam M G, Ikram, M Arfan, Ikram, M Kamran

“…Abstract Case-control studies are an important part of the epidemiologic literature, yet confusion remains about how to interpret estimates from different…”
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Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia by Evans, Tavia E., Adams, Hieab H.H., Licher, Silvan, Wolters, Frank J., van der Lugt, Aad, Ikram, M. Kamran, O'Sullivan, Michael J., Vernooij, Meike W., Ikram, M. Arfan

“…Total hippocampal volume has been consistently linked to cognitive function and dementia. Yet, given its complex and parcellated internal structure, the role…”
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Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study by van der Willik, Kimberly D, Fani, Lana, Rizopoulos, Dimitris, Licher, Silvan, Fest, Jesse, Schagen, Sanne B, Ikram, M Kamran, Ikram, M Arfan

“…Immunity has been suggested to be important in the pathogenesis of dementia. However, the contribution of innate versus adaptive immunity in the development of…”
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Circulating biomarkers of immunity and inflammation, risk of Alzheimer’s disease, and hippocampal volume: a Mendelian randomization study by Fani, Lana, Georgakis, Marios K., Ikram, M. Arfan, Ikram, M. Kamran, Malik, Rainer, Dichgans, Martin

“…The aim of this study was to explore the association between genetically predicted circulating levels of immunity and inflammation, and the risk of Alzheimer’s…”
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Long-term trajectories of decline in cognition and daily functioning before and after stroke by Heshmatollah, Alis, Dommershuijsen, Lisanne J., Fani, Lana, Koudstaal, Peter J., Ikram, M. Arfan, Ikram, M. Kamran

“…ObjectiveAlthough knowledge on poststroke cognitive and functional decline is increasing, little is known about the possible decline of these functions before…”
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Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI by Wolters, Frank J, Zonneveld, Hazel I, Licher, Silvan, Cremers, Lotte G.M, Ikram, M Kamran, Koudstaal, Peter J, Vernooij, Meike W, Ikram, M Arfan

“…OBJECTIVETo determine the long-term association of hemoglobin levels and anemia with risk of dementia, and explore underlying substrates on brain MRI in the…”
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