Search Results - "Ikonomovic, M.D."

Hippocampal plasticity during the progression of Alzheimer’s disease by Mufson, E.J, Mahady, L, Waters, D, Counts, S.E, Perez, S.E, DeKosky, S.T, Ginsberg, S.D, Ikonomovic, M.D, Scheff, S.W, Binder, L.I

“…Highlights • Hippocampal plasticity in AD. • Molecular plasticity in AD. • Hippocampal vulnerability in AD…”
Get full text

55 Cholinergic and amyloid activity in prodromal AD: implications for disease treatment by Mufson, Elliott, Counts, S.E, Ikonomovic, M.D

Get full text

Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease by IKONOMOVIC, M. D, KLUNK, W. E, ABRAHAMSON, E. E, WUU, J, MATHIS, C. A, SCHEFF, S. W, MUFSON, E. J, DEKOSKY, S. T

“…This study examined the relationship between postmortem precuneus cholinergic enzyme activity, Pittsburgh compound B (PiB) binding, and soluble amyloid-β…”
Get full text

Synapse stability in the precuneus early in the progression of Alzheimer's disease by Scheff, Stephen W, Price, Douglas A, Schmitt, Frederick A, Roberts, Kelly N, Ikonomovic, Milos D, Mufson, Elliott J

“…Amnestic mild cognitive impairment (aMCI) is considered to be one of the early stages in the progression from no cognitive impairment (NCI) to Alzheimer's…”
Get more information

Kalirin Reduction Rescues Psychosis-Associated Behavioral Deficits in APPswe/PSEN1dE9 Transgenic Mice by Krivinko, J.M, Erickson, S.L, Abrahamson, E.E, Wills, Z.P, Ikonomovic, M.D, Penzes, P, Sweet, R.A

“…Abstract Psychosis in Alzheimer disease (AD+P) represents a distinct clinical and neurobiological AD phenotype, and is associated with more rapid cognitive…”
Get full text

An immunohistochemical study of the serotonin 1A receptor in the hippocampus of subjects with Alzheimer's disease by Mizukami, Katsuyoshi, Ishikawa, Masanori, Akatsu, Hiroyasu, Abrahamson, Eric E., Ikonomovic, Milos D., Asada, Takashi

“…Alzheimer's disease (AD) is associated with neuronal degeneration, synaptic loss and deficits in multiple neurotransmitter systems. Alterations in the…”
Get full text

Assessing the threshold for in vivo detection of amyloid-beta plaques by Mathis, C.A., Klunk, W.E., Abrahamson, E.E., Hamilton, R.L., Price, J.C., Saxton, J.A., Lopez, O.L., DeKosky, S.T., Ikonomovic, M.D.

“…Compared to the same brain regions analyzed in a previously reported PiB-PET positive (PiB(+)) AD case (Ikonomovic et al., 2008), the PiB(-) DLB case had lower…”
Get full text

Biochemical analysis of GABAA receptor subunits α1, α5, β1, β2 in the hippocampus of patients with Alzheimer's disease neuropathology by RISSMAN, R. A, MISHIZEN-EBERZ, A. J, CARTER, T. L, WOLFE, B. B, DE BLAS, A. L, MIRALLES, C. P, IKONOMOVIC, M. D, ARMSTRONG, D. M

Get full text

Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: Protection with antioxidants and glutamate receptor antagonists by Atabay, C., Cagnoli, C.M., Kharlamov, E., Ikonomovic, M.D., Manev, H.

“…Cerebellar granule neurons undergo apoptosis when deprived of chronic depolarization; serum deprivation has not been considered as a trigger of apoptosis in…”
Get full text

Comparison of the binding of 3′-F-PiB and PiB in human brain homogenates by Mathis, Chester A., Ikonomovic, M.D., Debnath, M.L., Hamilton, R.L., DeKosky, S.T., Klunk, W.E.

“…Introduction Extensive studies of the binding of Pittsburgh Compound B (PiB) to amyloid-beta (Aβ) have been performed in human and transgenic mouse brain…”
Get full text

Biochemical analysis of GABA A receptor subunits α1, α5, β1, β2 in the hippocampus of patients with Alzheimer's disease neuropathology by Rissman, R.A, Mishizen-Eberz, A.J, Carter, T.L, Wolfe, B.B, De Blas, A.L, Miralles, C.P, Ikonomovic, M.D, Armstrong, D.M

“…Alzheimer's disease (AD) is characterized by selective vulnerability of specific neuronal populations within particular brain regions. For example, hippocampal…”
Get full text