Search Results - "Ikeda, Yasuhiko"

Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans by Maeda, Kazuya, Tian, Ying, Fujita, Tomoe, Ikeda, Yasuhiko, Kumagai, Yuji, Kondo, Tsunenori, Tanabe, Kazunari, Nakayama, Hideki, Horita, Shigeru, Kusuhara, Hiroyuki, Sugiyama, Yuichi

“…[Display omitted] Probe substrates for, and inhibitors of, specific transporters are desired to evaluate quantitatively the in vivo functions of transporters…”
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Pharmacokinetics and pharmacodynamics of prasugrel in healthy Japanese subjects by Umemura, Kazuo, Ikeda, Yasuhiko, Kondo, Kazunao

“…This randomized double-blind and placebo-controlled study assessed the pharmacodynamics and pharmacokinetics of prasugrel in healthy adult Japanese male…”
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Phase I clinical study of NMK36: a new PET tracer with the synthetic amino acid analogue anti-[18F]FACBC by Asano, Yuji, Inoue, Yusuke, Ikeda, Yasuhiko, Kikuchi, Kei, Hara, Toshimasa, Taguchi, Chikako, Tokushige, Takanori, Maruo, Hideki, Takeda, Tohoru, Nakamura, Tomomi, Fujita, Tomoe, Kumagai, Yuji, Hayakawa, Kazushige

“…Objective NMK36 is a novel PET tracer containing a synthetic amino acid analogue anti -[ 18 F]FACBC as the active ingredient, and is under development for the…”
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Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation by Cheng, Jiayi, Kondo, Kazunao, Suzuki, Yasuhiro, Ikeda, Yasuhiko, Meng, Xiansheng, Umemura, Kazuo

“…Total flavones of Hippophae Rhamnoides L (TFH) are extracted from Sea buckthorn, a Chinese herbal medicine. Sea buckthorn has antioxidant, anti-ulcerogenic and…”
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Antithrombotic effect of geniposide and genipin in the mouse thrombosis model by Suzuki, Y, Kondo, K, Ikeda, Y, Umemura, K

“…Geniposide is one of the constituents of Gardenia fruit (Gardenia jasminoides Ellis, Rubiaceae), which has been used in traditional medicine. Although its…”
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Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice by Zhao, Bing-Qiao, Ikeda, Yasuhiko, Ihara, Hayato, Urano, Tetsumei, Fan, WenYing, Mikawa, Sumiko, Suzuki, Yasuhiro, Kondo, Kazunao, Sato, Kohji, Nagai, Nobuo, Umemura, Kazuo

“…Cerebral hemorrhage associated with antithrombotic and thrombolytic therapy in acute stroke continues to present a major clinical problem. Rupture of the…”
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Experimental study on the protective effects of edaravone against ischemic spinal cord injury by Suzuki, Kazuchika, Kazui, Teruhisa, Terada, Hitoshi, Umemura, Kazuo, Ikeda, Yasuhiko, Bashar, Abul Hasan Muhammad, Yamashita, Katsushi, Washiyama, Naoki, Suzuki, Takayasu, Ohkura, Kazuhiro, Yasuike, Junji

“…Reactive free radical species are thought to be involved in ischemic spinal cord injury. We investigated the effects of edaravone (Mitsubishi Pharma Co, Tokyo,…”
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Analysis of reference values of serum S100B concentrations of Japanese adults by Ikeda, Yasuhiko, Umemura, Kazuo

“…S100B is a calcium-binding protein which exists in abundance in glial cells of the central nervous system (CNS). It is reported that the serum S100B level…”
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Combination of a free radical scavenger and heparin reduces cerebral hemorrhage after heparin treatment in a rabbit middle cerebral artery occlusion model by ZHAO, Bing-Qiao, SUZUKI, Yasuhiro, KONDO, Kazunao, IKEDA, Yasuhiko, UMEMURA, Kazuo

“…We sought to investigate the effects of EPC-K1, a free radical scavenger, on reducing heparin-produced cerebral hemorrhage in a rabbit model of middle cerebral…”
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Wortmannin, a potent antineutrophil agent, exerts cardioprotective effects in myocardial ischemia/reperfusion by Young, L H, Ikeda, Y, Scalia, R, Lefer, A M

“…Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in a marked cardiac contractile dysfunction. Wortmannin, a…”
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ME3277, a GPIIb/IIIa Antagonist Reduces Cerebral Infarction Without Enhancing Intracranial Hemorrhage in Photothrombotic Occlusion of Rabbit Middle Cerebral Artery by Kawano, Ken-Ichi, Fujishima, Kazuyuki, Ikeda, Yasuhiko, Kondo, Kazunao, Umemura, Kazuo

“…GPIIb/IIIa antagonists are expected to have a beneficial effect on acute cerebral infarction, however, the occurrence of intracranial hemorrhage has not been…”
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Hydroxyl radical generation after the third hour following ischemia contributes to brain damage by Takamatsu, Hiroyuki, Kondo, Kazunao, Ikeda, Yasuhiko, Umemura, Kazuo

“…The purpose of the present study was to determine after what time period hydroxyl radical formation contributes most to ischemic brain damage in focal…”
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Inhibitory mechanism of tranilast in human coronary artery smooth muscle cells proliferation, due to blockade of PDGF‐BB‐receptors by Watanabe, Shinji, Matsuda, Akihisa, Suzuki, Yasuhiro, Kondo, Kazunao, Ikeda, Yasuhiko, Hashimoto, Hisakuni, Umemura, Kazuo

“…We have previously reported that tranilast, an anti‐allergic drug, prevented the experimental intimal thickening in the rat and mouse femoral arteries and its…”
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Standardization of bleeding time by IVY method in male Japanese healthy volunteers by Ikeda, Yasuhiko, Kondo, Kazunao, Umemura, Kazuo

“…In the development of new antithrombotic agents, the bleeding time has been used to evaluate the anti-hemostatic effects and predict the bleeding tendency. The…”
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Pharmacokinetics and pharmacodynamics of ()‐sotalol in healthy male volunteers by KIMURA, MASAHIKO, UMEMURA, KAZUO, IKEDA, YASUHIKO, KOSUGE, KAZUHIRO, MIZUNO, ATSUHIRO, NAKANOMYO, HIROSHI, &, KYOICHI OHASHI, NAKASHIMA, MITSUYOSHI

“…1 We investigated the pharmacokinetics and pharmacodynamics of (±)‐sotalol administered orally to healthy male volunteers in single doses of 40, 80 and 160 mg…”
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Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia by Kanezaki, Rika, Toki, Tsutomu, Terui, Kiminori, Xu, Gang, Wang, RuNan, Shimada, Akira, Hama, Asahito, Kanegane, Hirokazu, Kawakami, Kiyoshi, Endo, Mikiya, Hasegawa, Daisuke, Kogawa, Kazuhiro, Adachi, Souichi, Ikeda, Yasuhiko, Iwamoto, Shotaro, Taga, Takashi, Kosaka, Yoshiyuki, Kojima, Seiji, Hayashi, Yasuhide, Ito, Etsuro

“…Twenty percent to 30% of transient abnormal myelopoiesis (TAM) observed in newborns with Down syndrome (DS) develop myeloid leukemia of DS (ML-DS). Most cases…”
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Platelet Aggregation Inhibitory Effects and Pharmacokinetics of Prasugrel Used in Combination With Aspirin in Healthy Japanese Subjects by Umemura, Kazuo, Ikeda, Yasuhiko, Matsushima, Nobuko, Kondo, Kazunao

“…We evaluated the pharmacokinetics and pharmacodynamics of prasugrel used in combination with aspirin in healthy Japanese subjects. All subjects received…”
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Pharmacokinetics of Voriconazole and Cytochrome p450 2C19 Genetic Status by Ikeda, Yasuhiko, Umemura, Kazuo, Kondo, Kazunao, Sekiguchi, Kaneo, Miyoshi, So, Nakashima, Mitsuyoshi

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Adenosine 5′-diphosphate as a factor in platelet aggregation induced by human plasma remnant lipoproteins by Saniabadi, Abby R., Umemura, Kazuo, Suzuki, Yasuhiro, Kondo, Kazunao, Ikeda, Yasuhiko, Adachi, Masakazu, Nakashima, Mitsuyoshi

“…The action of lipoprotein lipase on chylomicrons (CM) and very low density lipoproteins (VLDL) produces remnant lipoproteins (RLP) which are rich in…”
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In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats by Fujita, Tomoe, Ishihara, Kazuhiko, Yasuda, Shuichi, Nakamura, Tomomi, Maeda, Mika, Kobayashi, Mami, Sahashi, Kunihiko, Ikeda, Yasuhiko, Kumagai, Yuji, Majima, Masataka

“…Indoxyl sulfate (IS) is an organic anion uremic toxin that accumulates in patients with chronic kidney disease (CKD). The aims of this study were to examine…”
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