Search Results - "Ikeda, E"

Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients by Nagata, Eiichiro, Ogino, Mieko, Iwamoto, Kounosuke, Kitagawa, Yasuhisa, Iwasaki, Yasuo, Yoshii, Fumihito, Ikeda, Joh-E

“…Bromocriptine mesylate (BRC), a dopamine D2 receptor agonist has been shown to confer neuroprotection, sustained motor function and slowed disease progression…”
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A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection by Kanno, Takuya, Yasutake, Kaori, Tanaka, Kazunori, Hadano, Shinji, Ikeda, Joh-E

“…Therapeutic agents to the central nervous system (CNS) need to be efficiently delivered to the target site of action at appropriate therapeutic levels…”
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Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms by Kano, Osamu, Tanaka, Kazunori, Kanno, Takuya, Iwasaki, Yasuo, Ikeda, Joh-E

“…The delineation of the molecular pathology underlying amyotrophic lateral sclerosis (ALS) is being hampered by the lack of suitable biomarkers. We have…”
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Anterior insular volume decrease is associated with dysfunction of the reward system in patients with chronic pain by Ikeda, E., Li, T., Kobinata, H., Zhang, S., Kurata, J.

“…Background Chronification of pain is associated with both anatomical and functional alterations of the brain. Alteration in regional grey matter volume might…”
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Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages by Iwata, T., Mizuno, N., Ishida, S., Kajiya, M., Nagahara, T., Kaneda-Ikeda, E., Yoshioka, M., Munenaga, S., Ouhara, K., Fujita, T., Kawaguchi, H., Kurihara, H.

“…Mesenchymal stem cell (MSC) transplantation is an effective periodontal regenerative therapy. MSCs are multipotent, have self-renewal ability, and can…”
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Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking by Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Akatsuka, Akira, Koike, Masato, Aoki, Masashi, Uchiyama, Yasuo, Itoyama, Yasuto, Ikeda, Joh-E

“…ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involved in macropinocytosis-associated endosome fusion and trafficking, and…”
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Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation by Shimozato, O, Waraya, M, Nakashima, K, Souda, H, Takiguchi, N, Yamamoto, H, Takenobu, H, Uehara, H, Ikeda, E, Matsushita, S, Kubo, N, Nakagawara, A, Ozaki, T, Kamijo, T

“…Although CD133 has been considered to be a molecular marker for cancer stem cells, its functional roles in tumorigenesis remain unclear. We here examined the…”
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Receptor-type protein tyrosine phosphatase [kappa] directly dephosphorylates CD133 and regulates downstream AKT activation by Shimozato, O, Waraya, M, Nakashima, K, Souda, H, Takiguchi, N, Yamamoto, H, Takenobu, H, Uehara, H, Ikeda, E, Matsushita, S, Kubo, N, Nakagawara, A, Ozaki, T, Kamijo, T

“…Although CD133 has been considered to be a molecular marker for cancer stem cells, its functional roles in tumorigenesis remain unclear. We here examined the…”
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A novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse model by Tanaka, Kazunori, Kanno, Takuya, Yanagisawa, Yoshiko, Yasutake, Kaori, Inoue, Satoshi, Hirayama, Noriaki, Ikeda, Joh-E

“…Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron degenerative disease. Given that oxidative stress and resulting chronic neuronal…”
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The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis by Kunita, Ryota, Otomo, Asako, Mizumura, Hikaru, Suzuki-Utsunomiya, Kyoko, Hadano, Shinji, Ikeda, Joh-E

“…Mutations in the ALS2 gene cause a number of recessive motor neuron diseases, indicating that the ALS2 protein (ALS2/alsin) is vital for motor neurons. ALS2…”
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Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis by Tanaka, Kazunori, Kanno, Takuya, Yanagisawa, Yoshiko, Yasutake, Kaori, Hadano, Shinji, Yoshii, Fumihito, Ikeda, Joh-E

“…Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Since…”
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Development in measurement of children's perceptions on built environment and their school travel routes by Ikeda, E, Oliver, M, Witten, K, Hinckson, E

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Prevalence of Cognitive Impairment in Heart Transplant Waiting-List Patients in a Developing Country by de Oliveira, F.M., Ikeda, E.T., Avila, M., Wozniak, I., Seguro, L., Santos, M., Feltrim, M., Barone, F., Issa, V., Lage, S., Bacal, F., Bocchi, E., Gaiotto, F., Nomura, C., Marcondes-Braga, F., Mangini, S.

“…Cognitive impairment and mood deviation often occurs in patients with heart failure. Frailty and sarcopenia have been widely studied in patients with heart…”
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Correction: Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Research in Japanese Patients by Nagata, Eiichiro, Ogino, Mieko, Iwamoto, Kounosuke, Kitagawa, Yasuhisa, Iwasaki, Yasuo, Yoshii, Fumihito, Ikeda, Joh-E

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A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2 by Showguchi-Miyata, Junko, Hosler, Betsy A, Devon, Rebecca S, Skaug, Jennifer, Scherer, Stephen W, Okada, Yoshinori, Hayden, Michael R, Kwiatkowski, Thomas, Hadano, Shinji, Otomo, Asako, Nasir, Jamal, Singaraja, Roshni, Rouleau, Guy A, Brown, Robert H, Ikeda, Joh-E, Sagie, Tally, Yanagisawa, Yoshiko, Miyamoto, Natsuki, Osuga, Hitoshi, Figlewicz, Denise A, Hand, Collette K

“…Amyotrophic lateral sclerosis 2 (ALS2) is an autosomal recessive form of juvenile ALS and has been mapped to human chromosome 2q33. Here we report the…”
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Cyclin-Dependent Kinases as a Therapeutic Target for Stroke by Osuga, H, Osuga, S, Wang, F, Fetni, R, Hogan, M J, Slack, R S, Hakim, A M, Ikeda, J E, Park, D S

“…Cyclin-dependent kinases (CDKs) are commonly known to regulate cell proliferation. However, previous reports suggest that in cultured postmitotic neurons,…”
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Interstitial lung disease induced by gefitinib and Toll-like receptor ligands is mediated by Fra-1 by Takada, Y, Gresh, L, Bozec, A, Ikeda, E, Kamiya, K, Watanabe, M, Kobayashi, K, Asano, K, Toyama, Y, Wagner, E F, Matsuo, K

“…The role of the AP-1 transcription factor Fra-1 (encoded by Fosl1 ) in inflammatory responses associated with lung disease is largely unknown. Here, we show…”
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Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking by Hadano, Shinji, Benn, Susanna C., Kakuta, Shigeru, Otomo, Asako, Sudo, Katsuko, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Mizumura, Hikaru, Shefner, Jeremy M., Cox, Gregory A., Iwakura, Yoichiro, Brown, Robert H., Ikeda, Joh-E

“…ALS2/alsin is a member of guanine nucleotide exchange factors for the small GTPase Rab5 (Rab5GEFs), which act as modulators in endocytic pathway…”
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ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth by Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Mizumura, Hikaru, Onoe, Kyuichiro, Osuga, Hitoshi, Hadano, Shinji, Ikeda, Joh-E.

“…Loss of function mutations in the ALS2 gene account for a number of juvenile/infantile recessive motor neuron diseases, indicating that its gene product,…”
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Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration by Hadano, Shinji, Kunita, Ryota, Otomo, Asako, Suzuki-Utsunomiya, Kyoko, Ikeda, Joh-E

“…ALS2 is a causative gene for a juvenile autosomal recessive form of motor neuron diseases (MNDs), including amyotrophic lateral sclerosis 2 (ALS2), juvenile…”
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