Search Results - "Ikeda, Daishiro"

A New Terrein Glucoside, a Novel Inhibitor of Angiogenin Secretion in Tumor Angiogenesis by Arakawa, Masayuki, Someno, Tetsuya, Kawada, Manabu, Ikeda, Daishiro

“…Angiogenesis is a critical step for the tumor therapy. Many angiogenic factors are involved in the tumor angiogenesis. In the course of our screening for…”
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Phthoxazolin A inhibits prostate cancer growth by modulating tumor–stromal cell interactions by Kawada, Manabu, Inoue, Hiroyuki, Usami, Ihomi, Ikeda, Daishiro

“…Because stroma in tumor tissues can promote prostate cancer development, modulation of tumor–stromal cell interactions may represent an attractive new strategy…”
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Rakicidin A: A Hypoxia-Selective Cytotoxin by Yamazaki, Yohko, Kunimoto, Setsuko, Ikeda, Daishiro

“…Hypoxia is a common feature of many solid tumors and contributes to their progression. Hypoxic cells in the tumor are not only involved in therapeutic…”
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Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis by Wada, Shun‐ichi, Usami, Ihomi, Umezawa, Yoji, Inoue, Hiroyuki, Ohba, Shun‐ichi, Someno, Tetsuya, Kawada, Manabu, Ikeda, Daishiro

“…(Cancer Sci 2010; 101: 743–750) Although cytostatin analog protein phosphatase 2A (PP2A)‐specific inhibitors are promising candidates of a new type of…”
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Insulin-like growth factor I secreted from prostate stromal cells mediates tumor-stromal cell interactions of prostate cancer by KAWADA, Manabu, INOUE, Hiroyuki, MASUDA, Tohru, IKEDA, Daishiro

“…Prostate cancer shows high expression of type I insulin-like growth factor (IGF-I) receptor (IGF-IR) and prostate stromal cells (PrSC) produce IGF-I. Although…”
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Leucinostatin A inhibits prostate cancer growth through reduction of insulin‐like growth factor‐I expression in prostate stromal cells by Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun‐Ichi, Masuda, Tohru, Momose, Isao, Ikeda, Daishiro

“…Targeting stroma in tumor tissues is an attractive new strategy for cancer treatment. We developed in vitro coculture system, in which the growth of human…”
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Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2 by Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun-ichi, Hatano, Masaki, Amemiya, Masahide, Hayashi, Chigusa, Usami, Ihomi, Abe, Hikaru, Watanabe, Takumi, Kinoshita, Naoko, Igarashi, Masayuki, Masuda, Tohru, Ikeda, Daishiro, Nomoto, Akio

“…Because stromal cells can regulate the growth and metastasis of tumor cells, a compound that modulates the interaction between the stromal cells and the tumor…”
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New atpenins, NBRI23477 A and B, inhibit the growth of human prostate cancer cells by Kawada, Manabu, Momose, Isao, Someno, Tetsuya, Tsujiuchi, Goh, Ikeda, Daishiro

“…The growth and metastasis of prostate cancer are regulated by prostate stroma through the tumor–stromal cell interactions. Small molecules that modulate the…”
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In vivo imaging of proteasome inhibition using a proteasome‐sensitive fluorescent reporter by Momose, Isao, Tatsuda, Daisuke, Ohba, Shun‐ichi, Masuda, Tohru, Ikeda, Daishiro, Nomoto, Akio

“…A proteasome degrades numerous regulatory proteins that are critical for tumor growth and is therefore recognized as a promising anticancer target. Determining…”
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Mitochondrial inhibitors show preferential cytotoxicity to human pancreatic cancer PANC-1 cells under glucose-deprived conditions by Momose, Isao, Ohba, Shun-ichi, Tatsuda, Daisuke, Kawada, Manabu, Masuda, Tohru, Tsujiuchi, Go, Yamori, Takao, Esumi, Hiroyasu, Ikeda, Daishiro

“…Large areas of tumor are nutrient-starved and hypoxic due to a disorganized vascular system. Therefore, we screened small molecules to identify cytotoxic…”
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Increased ABCB1 Expression in TP-110-Resistant RPMI-8226 Cells by IIJIMA, Masatomi, MOMOSE, Isao, IKEDA, Daishiro

“…TP-110, a novel proteasome inhibitor, has been found to possess potent growth inhibition in human multiple myeloma cells. To enhance its therapeutic effects,…”
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NBRI16716A, a new antitumor compound against human prostate cancer cells, produced by Perisporiopsis melioloides Mer-f16716 by Kawada, Manabu, Someno, Tetsuya, Inoue, Hiroyuki, Ohba, Shun-ichi, Masuda, Tohru, Kato, Taira, Ikeda, Daishiro

“…Prostate stroma can regulate the growth and metastasis of prostate cancer through the tumor–stromal cell interactions. Thus, small molecules that modulate the…”
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Structure–activity relationship of boronic acid derivatives of tyropeptin: Proteasome inhibitors by Watanabe, Takumi, Abe, Hikaru, Momose, Isao, Takahashi, Yoshikazu, Ikeda, Daishiro, Akamatsu, Yuzuru

“…The structure–activity relationship of the boronic acid derivatives of tyropeptin, a proteasome inhibitor, was studied. Among 41 derivatives,…”
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Citric acid inhibits a bacterial ceramidase and alleviates atopic dermatitis in an animal model by Inoue, Hiroyuki, Someno, Tetsuya, Kawada, Manabu, Ikeda, Daishiro

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Synthesis of boronic acid derivatives of tyropeptin: Proteasome inhibitors by Watanabe, Takumi, Momose, Isao, Abe, Masatoshi, Abe, Hikaru, Sawa, Ryuichi, Umezawa, Yoji, Ikeda, Daishiro, Takahashi, Yoshikazu, Akamatsu, Yuzuru

“…Synthesis of boronic acid derivatives ( 3a– c) of tyropeptin, proteasome inhibitors, are reported. Boronic acid derivatives of tyropeptin were synthesized with…”
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Inhibitors of insulin-like growth factor-1 receptor tyrosine kinase are preferentially cytotoxic to nutrient-deprived pancreatic cancer cells by Momose, Isao, Kunimoto, Setsuko, Osono, Michiyo, Ikeda, Daishiro

“…Chronic deprivation of nutrients is rare in normal tissues, however large areas of tumor are nutrient-starved and hypoxic due to a disorganized vascular…”
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TP-110, a New Proteasome Inhibitor, Down-regulates IAPs in Human Multiple Myeloma Cells by IIJIMA, Masatomi, MOMOSE, Isao, IKEDA, Daishiro

“…TP-110, a new proteasome inhibitor, has previously shown potent growth inhibition in various tumor cell lines. In this study, the mechanism of TP-110-induced…”
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Drug-induced readthrough of premature stop codons leads to the stabilization of laminin α2 chain mRNA in CMD myotubes by Allamand, Valérie, Bidou, Laure, Arakawa, Masayuki, Floquet, Célia, Shiozuka, Masataka, Paturneau-Jouas, Marion, Gartioux, Corine, Butler-Browne, Gillian S., Mouly, Vincent, Rousset, Jean-Pierre, Matsuda, Ryoichi, Ikeda, Daishiro, Guicheney, Pascale

“…Background The most common form of congenital muscular dystrophy is caused by a deficiency in the α2 chain of laminin‐211, a protein of the extracellular…”
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Negamycin Restores Dystrophin Expression in Skeletal and Cardiac Muscles of mdx Mice by Arakawa, Masayuki, Shiozuka, Masataka, Nakayama, Yuki, Hara, Takahiko, Hamada, Masa, Kondo, Shin’ichi, Ikeda, Daishiro, Takahashi, Yoshikazu, Sawa, Ryuichi, Nonomura, Yoshiaki, Sheykholeslami, Kianoush, Kondo, Kenji, Kaga, Kimitaka, Kitamura, Toshio, Suzuki-Miyagoe, Yuko, Takeda, Shin’ichi, Matsuda, Ryoichi

“…The ability of aminoglycoside antibiotics to promote read-through of nonsense mutations has attracted interest in these drugs as potential therapeutic agents…”
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Ceramidastin, a novel bacterial ceramidase inhibitor, produced by Penicillium sp. Mer-f17067 by Inoue, Hiroyuki, Someno, Tetsuya, Kato, Taira, Kumagai, Hiroyuki, Kawada, Manabu, Ikeda, Daishiro

“…Decrease of ceramide in the skin is one of the aggravating factors of atopic dermatitis. The skin is often infected by ceramidase-producing bacteria, such as…”
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