Search Results - "Iio, Kiyosei"

Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses by Oikawa, Daisuke, Sato, Yusuke, Ohtake, Fumiaki, Komakura, Keidai, Hanada, Kazuki, Sugawara, Koji, Terawaki, Seigo, Mizukami, Yukari, Phuong, Hoang T., Iio, Kiyosei, Obika, Shingo, Fukushi, Masaya, Irie, Takashi, Tsuruta, Daisuke, Sakamoto, Shinji, Tanaka, Keiji, Saeki, Yasushi, Fukai, Shuya, Tokunaga, Fuminori

“…The NF-κB and interferon antiviral signaling pathways play pivotal roles in inflammatory and innate immune responses. The LUBAC ubiquitin ligase complex,…”
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Identification of inactive conformation‐selective interleukin‐2‐inducible T‐cell kinase (ITK) inhibitors based on second‐harmonic generation by Hantani, Yoshiji, Iio, Kiyosei, Hantani, Rie, Umetani, Kayo, Sato, Toshihiro, Young, Tracy, Connell, Katelyn, Kintz, Sam, Salafsky, Joshua

“…Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective…”
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Enantioselective Total Synthesis of a Potent Antitumor Antibiotic, Fredericamycin A by Kita, Yasuyuki, Higuchi, Kazuhiro, Yoshida, Yutaka, Iio, Kiyosei, Kitagaki, Shinji, Ueda, Koichiro, Akai, Shuji, Fujioka, Hiromichi

“…The asymmetric total synthesis of both enantiomers of the potent antitumor antibiotic fredericamycin A (1) is detailed based on the protocol for the…”
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Asymmetric Total Synthesis of Fredericamycin A: An Intramolecular Cycloaddition Pathway by Akai, Shuji, Tsujino, Toshiaki, Fukuda, Nobuhisa, Iio, Kiyosei, Takeda, Yoshifumi, Kawaguchi, Ken-ichi, Naka, Tadaatsu, Higuchi, Kazuhiro, Akiyama, Emi, Fujioka, Hiromichi, Kita, Yasuyuki

“…The asymmetric total synthesis of the potent antitumor antibiotic fredericamycin A ((S)‐1) was achieved by the intramolecular [4+2] cycloaddition of the…”
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Ambident Effect of a p-Sulfinyl Group for the Introduction of Two Carbon Substituents to Phenol Rings:  A Convergent Synthesis of Diverse Benzofuran Neolignans by Akai, Shuji, Morita, Nobuyoshi, Iio, Kiyosei, Nakamura, Yuka, Kita, Yasuyuki

“…A convergent synthesis of diversely substituted benzofuran neolignans (8) is described employing a single p-sulfinyl group on the phenols (3) as an ambident…”
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Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling by Katsuya, Ken, Oikawa, Daisuke, Iio, Kiyosei, Obika, Shingo, Hori, Yuji, Urashima, Toshiki, Ayukawa, Kumiko, Tokunaga, Fuminori

“…Nuclear factor-κB (NF-κB) is a crucial transcription factor family involved in the regulation of immune and inflammatory responses and cell survival. The…”
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Asymmetric Total Synthesis of Fredericamycin A by Kita, Yasuyuki, Higuchi, Kazuhiro, Yoshida, Yutaka, Iio, Kiyosei, Kitagaki, Shinji, Akai, Shuji, Fujioka, Hiromichi

“…Seventeen years after the isolation of the promising antitumor antibiotic fredericamycin A, the first asymmetric total synthesis of this compound has been…”
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Total Synthesis of the Antitumor Antibiotic (±)-Fredericamycin A by a Linear Approach by Kita, Yasuyuki, Iio, Kiyosei, Kawaguchi, Ken-ichi, Fukuda, Nobuhisa, Takeda, Yoshifumi, Ueno, Hiroshi, Okunaka, Ryuichi, Higuchi, Kazuhiro, Tsujino, Toshiaki, Fujioka, Hiromichi, Akai, Shuji

“…A linear approach to the total synthesis of racemic fredericamycin A (1) through the oxidative intramolecular [4+2] cycloaddition of a…”
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Novel ipso-Substitution of p-Sulfinylphenols through the Pummerer-Type Reaction:  A Selective and Efficient Synthesis of p-Quinones and Protected p-Dihydroquinones by Akai, Shuji, Takeda, Yoshifumi, Iio, Kiyosei, Takahashi, Kenji, Fukuda, Nobuhisa, Kita, Yasuyuki

“…The treatment of p-sulfinylphenols 3a − q with trifluoroacetic anhydride caused a Pummerer-type reaction on aromatic rings and concomitant desulfurization to…”
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Regioselective Synthesis of 2,3,5- Trisubstituted Indoles from p-Sulfinyl-aniline by Dual Use of the Sulfinyl Group by Kita, Yasuyuki, Akai, Shuji, Kawashita, Norihito, Morita, Nobuyoshi, Nakamura, Yuka, Iio, Kiyosei

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Synthesis of p-phenylthio- peri-hydroxy polyaromatic compounds by strong-base-induced [4+2] cycloaddition of 4-(phenylthio)homophthalic anhydrides with phenylsulfinyl- dienophiles by Iio, Kiyosei, Okajima, Akiko, Takeda, Yoshifumi, Kawaguchi, Ken-ichi, Whelan, Brendan A., Akai, Shuji, Kita, Yasuyuki

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Discovery of 6‑Phenylpyrimido[4,5‑b][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents by Fox, Brian M, Sugimoto, Kazuyuki, Iio, Kiyosei, Yoshida, Atsuhito, Zhang, Jian (Ken), Li, Kexue, Hao, Xiaolin, Labelle, Marc, Smith, Marie-Louise, Rubenstein, Steven M, Ye, Guosen, McMinn, Dustin, Jackson, Simon, Choi, Rebekah, Shan, Bei, Ma, Ji, Miao, Shichang, Matsui, Takuya, Ogawa, Nobuya, Suzuki, Masahiro, Kobayashi, Akio, Ozeki, Hidekazu, Okuma, Chihiro, Ishii, Yukihito, Tomimoto, Daisuke, Furakawa, Noboru, Tanaka, Masahiro, Matsushita, Mutsuyoshi, Takahashi, Mitsuru, Inaba, Takashi, Sagawa, Shoichi, Kayser, Frank

“…The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is…”
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An efficient p-thiocyanation of phenols and naphthols using a reagent combination of phenyliodine dichloride and lead(II) thiocyanate by KITA, Y, TAKEDA, Y, OKUNO, T, EGI, M, IIO, K, KAWAGUCHI, K.-I, AKAI, S

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Discovery of pyrrolopyridazines as novel DGAT1 inhibitors by Fox, Brian M., Iio, Kiyosei, Li, Kexue, Choi, Rebeka, Inaba, Takashi, Jackson, Simon, Sagawa, Shoichi, Shan, Bei, Tanaka, Masahiro, Yoshida, Atsuhito, Kayser, Frank

“…A new structural class of DGAT1 inhibitors possessing a pyrrolopyridazine core has been discovered. The optimization of DGAT1 inhibitory activity and increase…”
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Enantiodivergent Synthesis of Either Enantiomer of ABCDE-Ring Analogue of Antitumor Antibiotic Fredericamycin A via Intramolecular [4 + 2] Cycloaddition Approach by Akai, Shuji, Tsujino, Toshiaki, Fukuda, Nobuhisa, Iio, Kiyosei, Takeda, Yoshifumi, Kawaguchi, Ken-ichi, Naka, Tadaatsu, Higuchi, Kazuhiro, Kita, Yasuyuki

“…An intramolecular enantiodivergent synthesis of both enantiomers of the ABCDE-ring analogue 22 of fredericamycin A is reported. Key steps involve an…”
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An Efficient Synthesis of peri-Hydroxy Aromatic Compounds via a Strong-Base-Induced [4+2] Cycloaddition of Homophthalic Anhydrides with Enolizable Enones by IIO, Kiyosei, RAMESH, Namakkal G., OKAJIMA, Akiko, HIGUCHI, Kazuhiro, FUJIOKA, Hiromichi, AKAI, Shuji, KITA, Yasuyuki

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An Efficient Synthesis of p eri-Hydroxy Aromatic Compounds via a Strong-Base-Induced [4+2] Cycloaddition of Homophthalic Anhydrides with Enolizable Enones by Iio, Kiyosei, Ramesh, Namakkal G, Okajima, Akiko, Higuchi, Kazuhiro, Fujioka, Hiromichi, Akai, Shuji, Kita, Yasuyuki

“…An efficient synthesis of peri-hydroxy aromatic compounds has been accomplished via a strong-base-induced [4+2] cycloaddition of homophthalic anhydrides with…”
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An efficient preparation of peri-hydroxy dihydroquinone derivatives through a pummerer-type rearrangement of silylene-protected peri-hydroxy aromatic sulfoxides by Kita, Yasuyuki, Takeda, Yoshifumi, Iio, Kiyosei, Yokogawa, Kayoko, Takahashi, Kenji, Akai, Shuji

“…Silylene protection of two dihydroxy groups of the peri-hydroxy aromatic sulfides 6a-f was essential for the subsequent Pummerer-type reaction. The overall…”
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An Efficient p-Thiocyanation of Phenols and Naphtols Using a Reagent combination of Phenyliodine Dichloride and Lead(II) Thiocyanate by KITA, Yasuyuki, TAKEDA, Yoshifumi, OKUNO, Takayuki, EGI, Masahiro, IIO, Kiyosei, KAWAGUCHI, Ken-ichi, AKAI, Shuji

“…A combination of PhICl2 and Pb(SCN)2 is effective for the p-selective thiocyanation of various types of p-unsubstituted phenols and naphthols 1 to give…”
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Isolation of the Quinone Mono O,S-Acetal Intermediates of the Aromatic Pummerer-Type Rearrangement of p-Sulfinylphenols with 1-Ethoxyvinyl Esters by Kita, Yasuyuki, Tekeda, Yoshifumi, Matsugi, Masato, Iio, Kiyosei, Gotanda, Kentoku, Murata, Kenji, Akai, Shuji

“…A versatile synthetic building block and evidence for the mechanism of the Pummerer‐type rearrangement have been obtained in the form of the acetal…”
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