Search Results - "Iijima, Takeshi"

Development of a novel in silico classification model to assess reactive metabolite formation in cysteine trapping assay and investigation of important substructures by Umemori, Yuki, Handa, Koichi, Yoshimura, Saki, Kageyama, Michiharu, Iijima, Takeshi

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CDK4/6 inhibitor-induced bone marrow micronuclei might be caused by cell cycle arrest during erythropoiesis by Okada, Yuki, Chikura, Satsuki, Kimoto, Takafumi, Iijima, Takeshi

“…A micronucleus test is generally used to evaluate the genotoxic potential of chemicals. Exaggerated erythropoiesis, as occurs following bleeding, may induce an…”
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A novel glucokinase activator TMG-123 causes long-lasting hypoglycemia and impairs spermatogenesis irreversibly in rats by Kobayashi, Taiki, Shimomoto, Takasumi, Tamura, Azusa, Namekawa, Junichi, Iijima, Takeshi, Ochiai, Hideharu

“…The importance of glucose is well known as an energy source in testes. In order to evaluate the effects of long-lasting hypoglycemia on testes, a novel…”
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Development of a Novel In Silico Classification Model to Assess Reactive Metabolite Formation in the Cysteine Trapping Assay and Investigation of Important Substructures by Umemori, Yuki, Handa, Koichi, Yoshimura, Saki, Kageyama, Michiharu, Iijima, Takeshi

“…Predicting whether a compound can cause drug-induced liver injury (DILI) is difficult due to the complexity of drug mechanism. The cysteine trapping assay is a…”
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On the difficulty of validating molecular generative models realistically: a case study on public and proprietary data by Handa, Koichi, Thomas, Morgan C., Kageyama, Michiharu, Iijima, Takeshi, Bender, Andreas

“…While a multitude of deep generative models have recently emerged there exists no best practice for their practically relevant validation. On the one hand,…”
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Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption by Yoshitomo, Aoi, Asano, Satoshi, Hozuki, Shizuka, Tamemoto, Yuta, Shibata, Yukihiro, Hashimoto, Natsumi, Takahashi, Keita, Sasaki, Yoko, Ozawa, Naoka, Kageyama, Michiharu, Iijima, Takeshi, Kazuki, Yasuhiro, Sato, Hiromi, Hisaka, Akihiro

“…Drug absorption from the gastrointestinal tract is often restricted by efflux transport by P-glycoprotein (P-gp) and metabolism by CYP3A4. Both localize in the…”
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Prevalence of gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database by Ito, Shuichi, Torii, Tomoko, Nakajima, Akihiro, Iijima, Takeshi, Murano, Hiroshi, Horiuchi, Hideki, Yamanaka, Hisashi, Honda, Masataka

“…Although gout is rare in children, chronic sustained hyperuricemia can lead to monosodium urate deposits progressing to gout, just as in adults. This study…”
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Urate-lowering therapy for gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database by Honda, Masataka, Horiuchi, Hideki, Torii, Tomoko, Nakajima, Akihiro, Iijima, Takeshi, Murano, Hiroshi, Yamanaka, Hisashi, Ito, Shuichi

“…Our previous research showed that uric acid lowering therapy (ULT) for gout and hyperuricemia is being prescribed for pediatric patients even though these…”
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The effects of long-lasting hypoglycemia on male reproductive organs in rats by Kobayashi, Taiki, Namekawa, Junichi, Shimomoto, Takasumi, Yasui, Mari, Iijima, Takeshi, Itano, Yasuhiro, Miura, Daishiro, Kasahara, Yoshinori

“…Glucose has an important role in spermatogenesis. Nevertheless there are few reports in which the effects of long-lasting hypoglycemia on male reproductive…”
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Vehicle Side Slip Angle Estimation Methodology Using a Drive Recorder by Iijima, Takeshi, Raksincharoensak, Pongsathorn, Michitsuji, Yohei, Nagai, Masao

“…In this paper we describe a side slip angle estimation methodology especially for a drive recorder which has limited vehicle sensing information. The drive…”
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Development of Novel Methods for QSAR Modeling by Machine Learning Repeatedly: A Case Study on Drug Distribution to Each Tissue by Handa, Koichi, Yoshimura, Saki, Kageyama, Michiharu, Iijima, Takeshi

“…Artificial intelligence is expected to help identify excellent candidates in drug discovery. However, we face a lack of data, as it is time-consuming and…”
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Prediction of Compound Plasma Concentration–Time Profiles in Mice Using Random Forest by Handa, Koichi, Wright, Peter, Yoshimura, Saki, Kageyama, Michiharu, Iijima, Takeshi, Bender, Andreas

“…Pharmacokinetic (PK) parameters such as clearance (CL) and volume of distribution (Vd) have been the subject of previous in silico predictive models. However,…”
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Prediction of Inhibitory Activity against the MATE1 Transporter via Combined Fingerprint- and Physics-Based Machine Learning Models by Handa, Koichi, Sasaki, Shunta, Asano, Satoshi, Kageyama, Michiharu, Iijima, Takeshi, Bender, Andreas

“…Renal secretion plays an important role in excretion of drug from the kidney. Two major transporters known to be highly involved in renal secretion are MATE1/2…”
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A Practical In Silico Method for Predicting Compound Brain Concentration–Time Profiles: Combination of PK Modeling and Machine Learning by Handa, Koichi, Fujita, Daichi, Hirano, Mariko, Yoshimura, Saki, Kageyama, Michiharu, Iijima, Takeshi

“…Given the aging populations in advanced countries globally, many pharmaceutical companies have focused on developing central nervous system (CNS) drugs…”
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Development of a 2D-QSAR Model for Tissue-to-Plasma Partition Coefficient Value with High Accuracy Using Machine Learning Method, Minimum Required Experimental Values, and Physicochemical Descriptors by Handa, Koichi, Sakamoto, Seishiro, Kageyama, Michiharu, Iijima, Takeshi

“…Background The demand for physiologically based pharmacokinetic (PBPK) model is increasing currently. New drug application (NDA) of many compounds is submitted…”
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An integrated population pharmacokinetic model of febuxostat in pediatric patients with hyperuricemia including gout and adult population of healthy subjects and patients with renal dysfunction by Iwama, Ryutaro, Nishida, Kimie, Ishii, Daisuke, Iijima, Takeshi

“…The study objective was to validate febuxostat dosage and administration in pediatric patients with hyperuricemia including gout, using an integrated…”
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Combined data-driven and mechanism-based approaches for human-intestinal-absorption prediction in the early drug-discovery stage by Handa, Koichi, Sugiyama, Sakae, Kageyama, Michiharu, Iijima, Takeshi

“…It is important to precisely predict the intestinal absorption ratio (Fa) at an early stage in the discovery of orally available drugs because it directly…”
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Helicobacter pylori-negative,non-steroidal anti-inflammatory drug:Negative idiopathic ulcers in Asia by Iijima, Katsunori, Kanno, Takeshi, Koike, Tomoyuki, Shimosegawa, Tooru

“…Since the discovery of Helicobacter pylori(H.pylori)infection in the stomach,the bacteria infection and non-steroidal anti-inflammatory drugs(NSAIDs)use had…”
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Specific mutation in exon 11 of c-kit proto-oncogene in a malignant gastrointestinal stromal tumor of the rectum by Yamaguchi, M, Miyaki, M, Iijima, T, Matsumoto, T, Kuzume, M, Matsumiya, A, Endo, Y, Sanada, Y, Kumada, K

“…Gastrointestinal stromal tumor (GIST) in the distal third of the rectum was detected in a 57-year-old man who underwent an abdominoperineal resection of the…”
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K-ras mutation and liver micrometastasis in colorectal cancer by Tsunoda, Akira, Tsunoda, Yuko, Kusano, Mitsuo, Iijima, Takeshi

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