Search Results - "Iijima, Takatoshi"

SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1 by Iijima, Takatoshi, Wu, Karen, Witte, Harald, Hanno-Iijima, Yoko, Glatter, Timo, Richard, Stéphane, Scheiffele, Peter

“…The assembly of synapses and neuronal circuits relies on an array of molecular recognition events and their modification by neuronal activity. Neurexins are a…”
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The effects of corticotropin-releasing factor on motor learning by Takeuchi, Eri, Hatanaka, Tomomi, Iijima, Takatoshi, Kimura, Minoru, Katoh, Akira

“…Corticotropin-releasing factor (CRF) is mainly secreted from the hypothalamic paraventricular nuclei and plays a crucial role in stress-related responses…”
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Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1 by Iijima, Takatoshi, Iijima, Yoko, Witte, Harald, Scheiffele, Peter

“…The unique functional properties and molecular identity of neuronal cell populations rely on cell type-specific gene expression programs. Alternative splicing…”
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Spatio-temporal regulations and functions of neuronal alternative RNA splicing in developing and adult brains by Iijima, Takatoshi, Hidaka, Chiharu, Iijima, Yoko

“…•Alternative splicing dynamically diversifies particular synaptic proteins.•STAR family is a key player in spatio-temporal alternative splicing in…”
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Distinct Expression of SLM2 Underlies Splicing-Dependent Trans-Synaptic Signaling of Neurexin Across GABAergic Neuron Subtypes by Sato, Yuji, Iijima, Yoko, Darwish, Mohamed, Sato, Tadayuki, Iijima, Takatoshi

“…The mammalian brain contains multiple types of neuronal cells with complex assemblies and distinct structural and functional properties encoded by divergent…”
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A Perspective on the Role of Dynamic Alternative RNA Splicing in the Development, Specification, and Function of Axon Initial Segment by Iijima, Takatoshi, Yoshimura, Takeshi

“…Alternative splicing is a powerful mechanism for molecular and functional diversification. In neurons, alternative splicing extensively controls various…”
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Activity-Dependent Bidirectional Regulation of GAD Expression in a Homeostatic Fashion Is Mediated by BDNF-Dependent and Independent Pathways by Hanno-Iijima, Yoko, Tanaka, Masami, Iijima, Takatoshi

“…Homeostatic synaptic plasticity, or synaptic scaling, is a mechanism that tunes neuronal transmission to compensate for prolonged, excessive changes in…”
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Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system by Ito, Masatoshi, Fujii, Natsuko, Kohara, Saori, Hori, Shuho, Tanaka, Masayuki, Wittwer, Christopher, Kikuchi, Kenta, Iijima, Takatoshi, Kakimoto, Yu, Hirabayashi, Kenichi, Kurotaki, Daisuke, Jessen, Henning J., Saiardi, Adolfo, Nagata, Eiichiro

“…Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is…”
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Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures by Sato, Yuji, Suzuki, Satoko, Iijima, Yoko, Iijima, Takatoshi

“…Neurexins (NRXs) and neuroligins (NLs) play important roles in synapse specification. The alternatively spliced segment 4 (AS4) of NRX genes (Nrxn) is a…”
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Neuron-derived neurotrophic factor protects against dexamethasone-induced skeletal muscle atrophy by Ozaki, Yuta, Ohashi, Koji, Otaka, Naoya, Ogawa, Hayato, Kawanishi, Hiroshi, Takikawa, Tomonobu, Fang, Lixin, Tatsumi, Minako, Takefuji, Mikito, Enomoto, Takashi, Darwish, Mohamed, Iijima, Yoko, Iijima, Takatoshi, Murohara, Toyoaki, Ouchi, Noriyuki

“…Skeletal muscle atrophy caused by various conditions including aging, nerve damage, and steroid administration, is a serious health problem worldwide. We…”
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Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure by Iijima, Yoko, Behr, Katharina, Iijima, Takatoshi, Biemans, Barbara, Bischofberger, Josef, Scheiffele, Peter

“…Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders characterized by impairments in social interactions and stereotyped…”
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Maternal immunoglobulin G affects brain development of mouse offspring by Sadakata, Mizuki, Fujii, Kazuki, Kaneko, Ryosuke, Hosoya, Emi, Sugimoto, Hisako, Kawabata-Iwakawa, Reika, Kasamatsu, Tetsuhiro, Hongo, Shoko, Koshidaka, Yumie, Takase, Akinori, Iijima, Takatoshi, Takao, Keizo, Sadakata, Tetsushi

“…Maternal immunoglobulin (Ig)G is present in breast milk and has been shown to contribute to the development of the immune system in infants. In contrast,…”
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Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons by Suzuki, Satoko, Ayukawa, Noriko, Okada, Chisa, Tanaka, Masami, Takekoshi, Susumu, Iijima, Yoko, Iijima, Takatoshi

“…Alternative splicing is crucial for molecular diversification, which greatly contributes to the complexity and specificity of neural functions in the central…”
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Distinct expression of Cbln family mRNAs in developing and adult mouse brains by Miura, Eriko, Iijima, Takatoshi, Yuzaki, Michisuke, Watanabe, Masahiko

“…Cbln1 belongs to the C1q and tumour necrosis factor superfamily, and plays crucial roles as a cerebellar granule cell‐derived transneuronal regulator for…”
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Activity-Dependent Repression of Cbln1 Expression: Mechanism for Developmental and Homeostatic Regulation of Synapses in the Cerebellum by Iijima, Takatoshi, Emi, Kyoichi, Yuzaki, Michisuke

“…Cbln1, which belongs to the C1q/tumor necrosis factor superfamily, is released from cerebellar granule cells and plays a crucial role in forming and…”
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Mechanisms and functions underlying neuronal activity-dependent alternative pre-mRNA splicing by Iijima, Takatoshi

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SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3′ UTR Isoforms in the Nervous System by Iijima, Yoko, Tanaka, Masami, Suzuki, Satoko, Hauser, David, Tanaka, Masayuki, Okada, Chisa, Ito, Masatoshi, Ayukawa, Noriko, Sato, Yuji, Ohtsuka, Masato, Scheiffele, Peter, Iijima, Takatoshi

“…Neuronal alternative splicing is a core mechanism for functional diversification. We previously found that STAR family proteins (SAM68, SLM1, SLM2) regulate…”
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Characterization of a transneuronal cytokine family Cbln − regulation of secretion by heteromeric assembly by Iijima, Takatoshi, Miura, Eriko, Matsuda, Keiko, Kamekawa, Yuichi, Watanabe, Masahiko, Yuzaki, Michisuke

“…Cbln1, a member of the C1q and tumor necrosis factor superfamily, plays crucial roles as a cerebellar granule cell‐derived transneuronal regulator of synapse…”
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Impaired motor functions in mice lacking the RNA-binding protein Hzf by Iijima, Takatoshi, Ogura, Hiroo, Takatsuki, Kanako, Kawahara, Shigenori, Wakabayashi, Kenichiro, Nakayama, Daisuke, Fujioka, Masato, Kimura, Yuki, Bernstein, Alan, Okano, Hirotaka James, Kirino, Yutaka, Okano, Hideyuki

“…Local protein synthesis in dendrites plays an important role in some aspects of neuronal development and synaptic plasticity. Neuronal RNA-binding proteins…”
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Characterization of novel C1q family proteins in adult brain by Miura, Eriko, Iijima, Takatoshi, Kondo, Tetsuro, Watanabe, Masahiko, Yuzaki, Michisuke

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