Search Results - "Iijima, Ayano"
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Expression of Rat Cyp27b1 in HepG2 Cells Using Adenovirus Vector and Its Application to Evaluation of Self-Made and Commercially Available Anti-Cyp27b1 Antibodies
Published in Journal of nutritional science and vitaminology (01-01-2023)“…Rat Cyp27b1 was successfully expressed in HepG2 cells using an adenovirus vector. High vitamin D 1α-hydroxylation activity was detected in them, whereas no…”
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Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector
Published in Scientific reports (28-10-2023)“…Type II rickets is a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. The main symptoms of this disease are bone dysplasia and…”
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Functional analysis of vitamin D receptor (VDR) using adenovirus vector
Published in The Journal of steroid biochemistry and molecular biology (01-06-2023)“…Recently, we generated type II rickets model rats, including Vdr(R270L), Vdr(H301Q), Vdr(R270L/H301Q), and Vdr-knockout (KO), by genome editing. All generated…”
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Characterization of Rickets Type II Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor
Published in Biomolecules (Basel, Switzerland) (01-11-2023)“…Vitamin D has been known to exert a wide range of physiological effects, including calcemic, osteogenic, anticancer, and immune responses. We previously…”
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Development of nanoluciferase-based sensing system that can specifically detect 1α,25-dihydroxyvitamin D in living cells
Published in The Journal of steroid biochemistry and molecular biology (01-03-2023)“…Previously, we reported a FLucN-LXXLL+LBD-FLucC system that detects VDR ligands using split firefly luciferase techniques, ligand binding domain (LBD) of VDR,…”
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